Navigation Links
Millions of DNA switches that power human genome's operating system are discovered
Date:9/5/2012

The locations of millions of DNA 'switches' that dictate how, when, and where in the body different genes turn on and off have been identified by a research team led by the University of Washington in Seattle. Genes make up only 2 percent of the human genome and were easy to spot, but the on/off switches controlling those genes were encrypted within the remaining 98 percent of the genome.

Without these switches, called regulatory DNA, genes are inert. Researchers around the world have been focused on identifying regulatory DNA to understand how the genome works. Using a new technology developed with funding from the National Human Genome Research Institute's ENCODE (ENCyclopedia Of DNA Elements) project, UW researchers created the first detailed maps of where regulatory DNA is located within hundreds of different kinds of living cells. They also compiled a dictionary of the instructions written within regulatory DNA -- the genome's programming language.

The findings are reported in two papers appearing in the Sept. 5 online issue of Nature.

"These breakthrough studies provide the first extensive maps of the DNA switches that control human genes," said Dr. John A. Stamatoyannopoulos, associate professor of genome sciences and medicine at the University of Washington, and senior author on both papers. "This information is vital to understanding how the body makes different kinds of cells, and how normal gene circuitry gets rewired in disease. We are now able to read the living human genome at an unprecedented level of detail, and to begin to make sense of the complex instruction set that ultimately influences a wide range of human biology."

Here are the key results:

1) The first detailed maps of regulatory DNA switches that make up the genome's 'operating system'.

The instructions within regulatory DNA are inscribed in small DNA 'words' that function as the docking sites for special prot
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Center will create self-powered health monitoring devices
2. Spinach power gets a big boost
3. Waste not, power up
4. The power to heal at the tips of your fingers
5. Wireless power for the price of a penny
6. BioPower Operations Corporation Announces that FTZ Exchange Signs Strategic Alliance with Capacity 360, LLC and Tom Settineri
7. Unique properties of graphene lead to a new paradigm for low-power telecommunications
8. UCLA-led research team develops worlds most powerful nanoscale microwave oscillators
9. Syracuse University researchers use nanotechnology to harness power of fireflies
10. U of S researchers create powerful new tool for research and drug development
11. MO BIO Laboratories, Inc. Launches the PowerMicrobiome™ RNA Isolation Kit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Millions of DNA switches that power human genome's operating system are discovered
(Date:11/26/2014)... Morristown, NJ (PRWEB) November 25, 2014 ... it has officially joined the Morris County (New ... MCCC, which is a leading business organization in ... unique opportunity to further engage some key clients ... have operations in the geographic area. Membership enables ...
(Date:11/26/2014)... Global biostimulants market is expected to ... estimated CAGR of 12.5%. In order to cater ... least ecological impacts, farmers are looking to adopt ... yield more effectively & efficiently. Biostimulants are consequently ... return on investments. , Leading companies in the ...
(Date:11/26/2014)... TOKYO , 25 novembre 2014 Theravalues ... Super sur le marché européen au salon Hi ... Amsterdam ). Curcumine la ... une technologie amorphe (non-cristalline) à des ingrédients approuvés ... est un pigment jaune présent dans la racine ...
(Date:11/24/2014)... -- Five American winners will receive the ... for Medical Sciences", in its 8 th term; ... , on 15 December 2014.      (Photo: ... Center which won the Hamdan Award for Volunteers in ... that aim to improve health and promote peace and ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Five US Winners Among Recipients of Hamdan Medical Awards 2
... be difficult for someone outside of a specialist field ... of available data can be bewildering. New research, published ... Biomedical Semantics , describes a method of social network ... sift through scientific literature and news articles to identify ...
... There was a lot of excitement a few years ... The approach could be used to build nanoparticles of ... as nano-tweezers, remained out of reach. An international team ... Ludwig-Maximillians-Universitaet Muenchen and Professor Friedrich Simmel of the Technische ...
... two-day workshop hosted by the National Nanotechnology Initiative (NNI) ... assess the current landscape of regional, state, and local ... with optional site visits on April 30 ... 319 SW Pine Street, Portland, OR Who: ...
Cached Biology Technology:Social networking shortcut to finding medical experts 2Nano spiral staircases modify light 2Registration now open: 2012 Regional, State, and Local Initiatives in Nanotechnology 2
(Date:11/4/2014)... November 4, 2014   ... growth   Fuel3D , a developer of ... funding round totaling $6.4 million (£4 million). This funding builds ... earlier this year and paves the way for the commercial ... The funding round was led by Chimera Partners and ...
(Date:11/3/2014)... 3, 2014 Research and Markets has ... - Technologies, Markets and Companies" to their offering. ... and methods, which have already started to play an important ... is replacing the old fashioned bone marrow transplants. Role of ... bound to become a part of medical practice. ...
(Date:11/3/2014)... and preterm birth are linked to increased risk for ... the American College of Rheumatology (ACR) journal, Arthritis ... and pre-term babies were not at greater risk of ... According to the ACR, 27 million Americans over the ... of OA range from mild to severe and include ...
Breaking Biology News(10 mins):Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3Preterm, low birth-weight babies may need new hips in adulthood 2
... D.C. (March 8, 2011) -- Researchers at the University ... Texas at Dallas are reporting today at the 55th ... they are using a novel 3D cell imaging method ... providing a solution to this fundamental problem in cell ...
... 8, 2011 New technology designed to revolutionize ... its initial operating capability, the FBI announced today. ... built by Lockheed Martin, delivers an incremental replacement ... (IAFIS). NGI provides automated fingerprint and latent search ...
... Pa. -- Crabs, fishing, land use and pollution sources ... Bay area, but finding all the available information, especially ... a project of the AmericaView consortium, brings together a ... who needs them for research, planning or other studies. ...
Cached Biology News:FBI Announces Initial Operating Capability for Next Generation Identification System 2ChesapeakeView: Everything you need to know about the bay 2
... a Perkin Elmer UltraVIEW system and want to ... and iQ software? No problem. Our experienced ... your existing microscope, lasers, Sutter filter wheel, Piezo ... work with our precision controller unit and workstation... ...
... Variable Speed Rocker, with 12" x 14" table; ... x 14" table; 220V. The VSR-50 Variable ... for any lab. The VSR-50 provides a rhythmic ... a gentle to vigourous movement. This makes it ...
...
...
Biology Products: