Navigation Links
Millions of DNA switches that power human genome's operating system are discovered
Date:9/5/2012

The locations of millions of DNA 'switches' that dictate how, when, and where in the body different genes turn on and off have been identified by a research team led by the University of Washington in Seattle. Genes make up only 2 percent of the human genome and were easy to spot, but the on/off switches controlling those genes were encrypted within the remaining 98 percent of the genome.

Without these switches, called regulatory DNA, genes are inert. Researchers around the world have been focused on identifying regulatory DNA to understand how the genome works. Using a new technology developed with funding from the National Human Genome Research Institute's ENCODE (ENCyclopedia Of DNA Elements) project, UW researchers created the first detailed maps of where regulatory DNA is located within hundreds of different kinds of living cells. They also compiled a dictionary of the instructions written within regulatory DNA -- the genome's programming language.

The findings are reported in two papers appearing in the Sept. 5 online issue of Nature.

"These breakthrough studies provide the first extensive maps of the DNA switches that control human genes," said Dr. John A. Stamatoyannopoulos, associate professor of genome sciences and medicine at the University of Washington, and senior author on both papers. "This information is vital to understanding how the body makes different kinds of cells, and how normal gene circuitry gets rewired in disease. We are now able to read the living human genome at an unprecedented level of detail, and to begin to make sense of the complex instruction set that ultimately influences a wide range of human biology."

Here are the key results:

1) The first detailed maps of regulatory DNA switches that make up the genome's 'operating system'.

The instructions within regulatory DNA are inscribed in small DNA 'words' that function as the docking sites for special prot
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Center will create self-powered health monitoring devices
2. Spinach power gets a big boost
3. Waste not, power up
4. The power to heal at the tips of your fingers
5. Wireless power for the price of a penny
6. BioPower Operations Corporation Announces that FTZ Exchange Signs Strategic Alliance with Capacity 360, LLC and Tom Settineri
7. Unique properties of graphene lead to a new paradigm for low-power telecommunications
8. UCLA-led research team develops worlds most powerful nanoscale microwave oscillators
9. Syracuse University researchers use nanotechnology to harness power of fireflies
10. U of S researchers create powerful new tool for research and drug development
11. MO BIO Laboratories, Inc. Launches the PowerMicrobiome™ RNA Isolation Kit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Millions of DNA switches that power human genome's operating system are discovered
(Date:5/27/2015)... , May 27, 2015 RXi ... company focused on discovering and developing innovative therapies ... today announced that it has commenced a public offering ... purchase shares of its common stock and overallotment ... stock. The shares of common stock, warrants and ...
(Date:5/27/2015)... VANCOUVER , May 27, 2015 /CNW/ - CQDM, ... award close to $8.5M to six (6) multi-disciplinary and ... in neuroscience within their Focus on Brain strategic initiative. ... research entities involved as in-kind contributions. This exciting announcement ... Canadian Association for Neuroscience in the presence of Inez ...
(Date:5/27/2015)...  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ) ("NW ... for cancer, announced today that Dr. Marnix L. ... be making an Industry Expert Theater Presentation at the ... on Saturday, May 30, 2015, from 3 to ... McCormick Place. Dr. Bosch will provide an ...
(Date:5/27/2015)... The Medical Innovation Impact Index (MI3), ... on medical innovation, has been developed at the ... Dickinson University’s ( FDU ) Rothman Institute of Innovation ... to new FDA (Food & Drug Administration) draft guidance ... of certain medical devices. , “The main impediment ...
Breaking Biology Technology:RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 2Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 4Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 5Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 6Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 7Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 8Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 9Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 10NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 2NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 3Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2
... the American Cancer Society, one in three people will ... lifetime. In an effort to improve patient care and ... has developed innovative medical imaging technologies that are allowing ... disease. , ,The latest cancer-fighting advancements from GE ...
... -- SoftSwitching Technologies' nationwide power-monitoring system is ... Outage Task Force in its newly released report ... that affected large portions of the Midwest and Northeast ... Federal Energy Regulatory Commission (FERC) and the Task Force ...
... Note: This is the first of a multi-part interview ... , managing director of the Wisconsin Alumni Research Foundation ... WARF initiative called Whats in it for Wisconsin Business. This ... foundation more accessible to companies throughout the state, as well ...
Cached Biology Technology:GE Medicals Technologies Aid Battle Against Cancer 2GE Medicals Technologies Aid Battle Against Cancer 3WTN Interviews: How WARF is Reaching Out to Businesses About Technology Developed in Wisconsin 2WTN Interviews: How WARF is Reaching Out to Businesses About Technology Developed in Wisconsin 3WTN Interviews: How WARF is Reaching Out to Businesses About Technology Developed in Wisconsin 4
(Date:4/21/2015)... , April 21, 2015 ... government policies are boosting access control systems market in ... According to a recently published report by TechSci Research ... ", the access control systems market in ... billion by 2020.The access control systems market in the ...
(Date:4/20/2015)... -- The announcement comes as demand for ... (GRM), Ireland,s foremost records management company, ... up an impressive track record of clients within the first ... records management sector in Dubai . As ... and employ a further eight staff members at its Irish ...
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
... A protein found present in all cells in the body ... Researchers at the University of Edinburgh have found that the ... present in lipid droplets the parts of cells used ... levels of invadolysin were linked to reduced amounts of fat ...
... In early 2008, there was a frightening failure ... more than 100 Americans had died after being administered ... contaminant, present in heparin manufactured in China and discovered ... was so structurally similar to pure heparin that is ...
... Institution $120,000 as part of an anticipated three-year, nearly ... brown tides on the East Coast. Funds were awarded ... Blooms (ECOHAB) program. The project will focus ... East Coast that causes tremendous damage to coastal habitats ...
Cached Biology News:Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals 2Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals 3New research to unravel how nutrients drive toxic 'brown tides' on East Coast 2
OSCP Antibody...
Smac/DIABLO (mouse) (CT) rabbit polyclonal antibody...
... polyclonal to Taura Syndrome Virus ... for all tested applications). ... peptide: VTNSEGSTIL MNDIPITNQN VVLSKNVTDN LFEVQDQALI ... to N terminal amino acids ...
Purified Mouse anti-Hu Actopaxin (pS8) Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: