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'Micro shuttle' drug delivery could mean an end to regular dosing
Date:10/1/2009

Scientists working at Queen Mary, University of London, have developed micrometer-sized capsules to safely deliver drugs inside living cells.

In the future, this technique could allow full courses of prescription drugs to be effectively 'shrink-wrapped' and buried under the skin or inside the body.

These "micro shuttles" can be loaded with a specific dose of medication and be opened remotely, releasing their contents.

Using this new technique, drugs - like insulin for managing diabetes - could be implanted inside the body for use when they are needed. Their release could then be prompted by a biological trigger like a drop in blood sugar levels, or activated manually with a pulse of light.

PhD student Matthieu Bdard and Prof Gleb Sukhorukov of Queen Mary's School of Engineering and Materials Science have proved this new technique to work in living tissue by delivering fluorescent test-molecules in light-activated capsules.

The work is in partnership with Dr Sebastian Springer at Jacobs University in Bremen and colleagues from the Max Plank Institute of Colloids. The findings are reported in the October issue of Small (DOI: 10.1002/smll.200900809).

Matthieu Bdard said: "The main advantage of using such microcapsules is that they can be designed to be very stable inside the body, protecting their contents. This is particularly important for the many medications that are rapidly degraded or altered by the body. These capsules can be used to 'store' drugs in the body for later use."

The capsules, which have a diameter of two micrometers (about the size of a bacterium), are built by wrapping strands of a metabolism-resistant material around spherical particles, which are then dissolved in acid, leaving behind an empty container.

To fill the capsules, the scientists heat them in a solution that contains the desired drug compound. This makes them shrink and traps some of the solution and co
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Contact: Simon Levey
s.levey@qmul.ac.uk
44-020-788-25404
Queen Mary, University of London
Source:Eurekalert

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