Navigation Links
Man-made pores mimic important features of natural pores
Date:7/17/2012

BUFFALO, N.Y. -- Inspired by nature, an international research team has created synthetic pores that mimic the activity of cellular ion channels, which play a vital role in human health by severely restricting the types of materials allowed to enter cells.

The pores the scientists built are permeable to potassium ions and water, but not to other ions such as sodium and lithium ions.

This kind of extreme selectivity, while prominent in nature, is unprecedented for a synthetic structure, said University at Buffalo chemistry professor Bing Gong, PhD, who led the study.

The project's success lays the foundation for an array of exciting new technologies. In the future, scientists could use such highly discerning pores to purify water, kill tumors, or otherwise treat disease by regulating the substances inside of cells.

"The idea for this research originated from the biological world, from our hope to mimic biological structures, and we were thrilled by the results," Gong said. "We have created the first quantitatively confirmed synthetic water channel. Few synthetic pores are so highly selective."

The research will appear July 17 in Nature Communications.

The study's lead authors are Xibin Zhou of Beijing Normal University; Guande Liu of Shanghai Jiao Tong University; Kazuhiro Yamato, postdoctoral scientist at UB; and Yi Shen of Shanghai Jiao Tong University and the Shanghai Institute of Applied Physics, Chinese Academy of Sciences. Other institutions that contributed to the work include the University of Nebraska-Lincoln and Argonne National Laboratory. Frank Bright, a SUNY Distinguished Professor of chemistry at UB, assisted with spectroscopic studies.

To create the synthetic pores, the researchers developed a method to force donut-shaped molecules called rigid macrocycles to pile on top of one another. The scientists then stitched these stacks of molecules together using hydrogen bonding. The resulting structure was a nanotube with a pore less than a nanometer in diameter.

"This nanotube can be viewed as a stack of many, many rings," said Xiao Cheng Zeng, University of Nebraska-Lincoln Ameritas University Professor of Chemistry, and one of the study's senior authors. "The rings come together through a process called self-assembly, and it's very precise. It's the first synthetic nanotube that has a very uniform diameter. It's actually a sub-nanometer tube. It's about 8.8 angstroms." (One angstrom is one-10th of a nanometer, which is one-billionth of a meter.)

The next step in the research is to tune the structure of the pores to allow different materials to selectively pass through, and to figure out what qualities govern the transport of materials through the pores, Gong said.


'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert  

Related biology technology :

1. BioNeutral Group Expands The Testing Of Its Ygiene Sterilant Against Anthrax Spores
2. University of Utah chemists use nanopores to detect DNA damage
3. Building Wireless Solution More Important than Ever with New Tablets
4. Carbon nanotubes can double growth of cell cultures important in industry
5. Spherix Announces Successful Completion of Important Toxicology Study of SPX-106
6. New method for producing precursor of neurons, bone and other important tissues from stem cells
7. Laboratory Equipment Marketplace LabX.com Receives Fresh Look and Updated Features
8. Tri-Valley Dentist Dr. Endre Selmeczy Currently Features Oral Sedation Dentistry
9. Eppendorf Video Features Dr Andrew Holts Work on Bioactive Leachates From Plastic Consumables
10. In Comes the Non-Toxic Rust Remover; Rusterizer Presents Its Rust Removal Product Made With Natural Ingredients
11. Evolution Issue of the Month 2. Natural Selection--Not the Best Idea Anyone Ever Had
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Man-made pores mimic important features of natural pores
(Date:2/20/2017)... (PRWEB) , ... February 20, 2017 , ... ... in patients with catheters associated with peritoneal dialysis, announced today that it has ... dialysis catheter connection system in Peritoneal Dialysis International (PDI), the official Journal ...
(Date:2/18/2017)... -- Kurzlehrgang mit Fokus auf Assay ... legt metaproteomische Analyse des Darm-Mikrobioms bei Säuglingen dar   ... ... Yoav Peretz , Scientific Director bei ImmuneCarta, einen Kurzlehrgang ... Nachweis intrazellulärer Zytokine bei adoptiven Zelltherapie-Studien im Rahmen der ...
(Date:2/17/2017)... FREMONT, Calif. , Feb. 17, 2017 /PRNewswire/ ... pleased to announce development of a novel system ... in collaboration with the University of Rochester (NY, ... ). The new system is able to ... cancer biomarker, HER2 (Human epidermal growth factor receptor-2) ...
(Date:2/16/2017)... Arbor, MI (PRWEB) , ... February 16, 2017 , ... ... 5:00-7:00 p.m. The event will be held at Avomeen Analytical Services (4840 Venture ... by a MichBio member organization. They provide an opportunity to interact with peers, make ...
Breaking Biology Technology:
(Date:1/30/2017)... FRANCISCO , Jan. 30, 2017   Invitae ... the fastest growing genetic information companies, today announced that ... financial results and provide 2017 guidance on Monday, February ... conference call that day at 4:45 p.m. Eastern / ... Invitae,s management team will briefly review financial results, guidance, ...
(Date:1/24/2017)... YORK , Jan. 24, 2017 ... study of the laboratory use of nuclear magnetic ... 363 experienced end-users and profiled current practices, developments, ... years, as well as growth and opportunities. These ... Instrument suppliers, NMR instruments, needs and innovation requirements, ...
(Date:1/19/2017)... January 19, 2017 According to a new report published ... 2014 - 2022," the global biometric sensor market is expected to garner $1.5 ... In 2015, Asia-Pacific dominated the global market and contributed ... Continue Reading ... ...
Breaking Biology News(10 mins):