Navigation Links
Man-made pores mimic important features of natural pores
Date:7/17/2012

BUFFALO, N.Y. -- Inspired by nature, an international research team has created synthetic pores that mimic the activity of cellular ion channels, which play a vital role in human health by severely restricting the types of materials allowed to enter cells.

The pores the scientists built are permeable to potassium ions and water, but not to other ions such as sodium and lithium ions.

This kind of extreme selectivity, while prominent in nature, is unprecedented for a synthetic structure, said University at Buffalo chemistry professor Bing Gong, PhD, who led the study.

The project's success lays the foundation for an array of exciting new technologies. In the future, scientists could use such highly discerning pores to purify water, kill tumors, or otherwise treat disease by regulating the substances inside of cells.

"The idea for this research originated from the biological world, from our hope to mimic biological structures, and we were thrilled by the results," Gong said. "We have created the first quantitatively confirmed synthetic water channel. Few synthetic pores are so highly selective."

The research will appear July 17 in Nature Communications.

The study's lead authors are Xibin Zhou of Beijing Normal University; Guande Liu of Shanghai Jiao Tong University; Kazuhiro Yamato, postdoctoral scientist at UB; and Yi Shen of Shanghai Jiao Tong University and the Shanghai Institute of Applied Physics, Chinese Academy of Sciences. Other institutions that contributed to the work include the University of Nebraska-Lincoln and Argonne National Laboratory. Frank Bright, a SUNY Distinguished Professor of chemistry at UB, assisted with spectroscopic studies.

To create the synthetic pores, the researchers developed a method to force donut-shaped molecules called rigid macrocycles to pile on top of one another. The scientists then stitched these stacks of molecules together using hydrogen bonding. The resulting structure was a nanotube with a pore less than a nanometer in diameter.

"This nanotube can be viewed as a stack of many, many rings," said Xiao Cheng Zeng, University of Nebraska-Lincoln Ameritas University Professor of Chemistry, and one of the study's senior authors. "The rings come together through a process called self-assembly, and it's very precise. It's the first synthetic nanotube that has a very uniform diameter. It's actually a sub-nanometer tube. It's about 8.8 angstroms." (One angstrom is one-10th of a nanometer, which is one-billionth of a meter.)

The next step in the research is to tune the structure of the pores to allow different materials to selectively pass through, and to figure out what qualities govern the transport of materials through the pores, Gong said.


'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert  

Related biology technology :

1. BioNeutral Group Expands The Testing Of Its Ygiene Sterilant Against Anthrax Spores
2. University of Utah chemists use nanopores to detect DNA damage
3. Building Wireless Solution More Important than Ever with New Tablets
4. Carbon nanotubes can double growth of cell cultures important in industry
5. Spherix Announces Successful Completion of Important Toxicology Study of SPX-106
6. New method for producing precursor of neurons, bone and other important tissues from stem cells
7. Laboratory Equipment Marketplace LabX.com Receives Fresh Look and Updated Features
8. Tri-Valley Dentist Dr. Endre Selmeczy Currently Features Oral Sedation Dentistry
9. Eppendorf Video Features Dr Andrew Holts Work on Bioactive Leachates From Plastic Consumables
10. In Comes the Non-Toxic Rust Remover; Rusterizer Presents Its Rust Removal Product Made With Natural Ingredients
11. Evolution Issue of the Month 2. Natural Selection--Not the Best Idea Anyone Ever Had
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Man-made pores mimic important features of natural pores
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont Pioneer ... that they have entered into a multiyear collaboration to identify and characterize novel ... additional tools for gene editing across all applications. , Under the terms of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Rosalindâ„¢, the first-ever genomics analysis platform specifically designed for life science researchers ... honor of pioneering researcher Rosalind Franklin, who made a major contribution to ...
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
Breaking Biology Technology:
(Date:8/23/2017)... help is being enlisted in what,s thought to be the biggest study ... body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date of ... goal is to help advance scientific knowledge of the role of these ... The Microbiome ...
(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their ... (DCA). ... launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at ... process to allow eligible Delta SkyMiles Members who are enrolled in CLEAR ...
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
Breaking Biology News(10 mins):