Navigation Links
Major disease-vector mosquito reveals the secrets of its immune system

1st October 2010 - The Culex quinquefasciatus mosquito poses a significant threat to human health as a blood-sucking transmitter of elephantiasis-causing worms and encephalitis-inducing viruses. An international team of scientists, including researchers from the University of Geneva and the SIB Swiss Institute of Bioinformatics sequenced its genome and studied its responses to pathogen infections. Two articles published in today's issue of Science, describe results from comparing the Culex mosquito with the malaria mosquito, Anopheles gambiae, and the dengue mosquito, Aedes aegypti, which offer new insights into the elimination of insect-transmitted diseases that seriously impact on global public health.

Mosquitoes are the most important disease-vectors. Species of Culex, Aedes, and Anopheles mosquitoes are responsible for the transmission of many human pathogens including parasites that cause malaria, viruses that trigger dengue and yellow fever, and West Nile encephalitis, as well as worms that cause lymphatic filariasis (also called elephantiasis). The capacity of different mosquito species to transmit these and other pathogens varies greatly, and much of this variation can be attributed to the mosquito immune system's ability to recognise and eliminate the pathogen. Applying their expertise in comparative evolutionary genomic analyses and insect immunity, Professor Evgeny Zdobnov and Dr Robert Waterhouse, from the University of Geneva Medical School and the SIB Swiss Institute of Bioinformatics, joined forces with scientists from around the world to examine the Culex genome and its encoded genes.

Sequencing of the Culex genome, directed by Peter Atkinson and Peter Arensburger from the University of California Riverside, allowed researchers to perform a thorough comparison among the three disease-vector mosquito species. Focusing on the mosquito immune system, researchers led by Professor Marc Muskavitch from Boston College, the Broad Institute, and Harvard School of Public Health, examined the responses of each mosquito species to different pathogens including parasites, viruses, bacteria, and worms, to identify genes that play a role in mosquito immune defences."Our pathogenomics study took advantage of the sequencing of the Culex quinquefasciatus genome" says Professor Muskavitch, "to bring together data from experiments profiling responses of mosquito genes to pathogen infections, directed by Professor Lyric Bartholomay, with the results of comparative immunogenomics analyses led by Dr Robert Waterhouse". This study revealed many differences among these three mosquito species, and also that Culex, the most geographically widespread, "has an expanded immune gene repertoire, which may enhance its ability to adapt to diverse habitats with different pathogen challenges", explains Dr Waterhouse.

"These important studies" says Professor Zdobnov, "highlight how genome sequencing can greatly facilitate detailed experimental investigations to uncover the complex biology of these major disease-vector mosquitoes". Professor Bartholomay, from Iowa State University, adds that "by comparing numerous combinations of mosquito species infected with different pathogen types, our results indicate that pathogens that successfully develop in, and are transmitted by, disease-vector mosquitoes, have evolved to avoid mosquito immune responses". Improving our understanding of these vector-pathogen relationships significantly advances the long-term objectives of developing strategies to reinforce the mosquitoes' defences, making them immune to infections and breaking the chain of pathogen transmission.


Contact: Irene Perovsek
Swiss Institute of Bioinoformatics

Related biology technology :

1. deCODE Discovers Major Genetic Risk Factor for the Most Common Form of Glaucoma
2. All-New Sermo Brings Major Enhancements to Nations Largest Online Physician Community
3. deCODE Discovers Genetic Risk Factor Linking Susceptibility to Four Major Vascular Diseases
4. Iowa Gains Momentum as Major Provider of Biorenewables
5. Orexigen(R) Therapeutics Announces That Contrave(R) Reduced Depression Scores and Body Weight in Overweight and Obese Patients With Major Depression
6. University of Minnesota researchers clear major hurdle in road to high-efficiency solar cells
7. Lexicon to Present at Two Major Healthcare Investor Conferences
8. Sensient Technologies Corporation Announces Major Investment in Natural Colors
9. Encorium Group, Inc. Announces New Business Contract Wins of $6.8 Million, Including Two Pivotal Phase III Studies for a Major Asian Technology Company
10. Epeius Biotechnologies Reports Major Clinical Advances: Noteworthy Clinical Case Studies in Cancer Gene Therapy
11. Graphene films clear major fabrication hurdle
Post Your Comments:
(Date:6/27/2016)... June 27, 2016  Sequenom, Inc. (NASDAQ: ... healthier lives through the development of innovative products and ... the United States denied its petition ... claims of Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") ... established by the Supreme Court,s Mayo Collaborative Services v. ...
(Date:6/27/2016)... Chapel Hill, N.C. (PRWEB) , ... June 27, ... ... of U.S. commercial operations for Amgen, will join the faculty of the ... will serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
Breaking Biology Technology:
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
(Date:6/9/2016)... -- Paris Police Prefecture ... to ensure the safety of people and operations in several ... tournament Teleste, an international technology group specialised in ... that its video security solution will be utilised by ... safety across the country. The system roll-out is scheduled for ...
(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
Breaking Biology News(10 mins):