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Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures
Date:7/23/2014

.comReferences

  1. UCB Data on File
  2. ClinicalTrials.gov identifier NCT01261325: https://clinicaltrials.gov/ct2/show/NCT01261325?term=NCT01261325&rank=1. Accessed 21st July 2014
  3. UCB Data on file
  4. Ryvlin, P., et al., Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial. Epilepsia, 2014. 55(1):47-56.
  5. Biton, V., et al., Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trial. Epilepsia, 2014. 55(1): 57-66.
  6. Kwan, P., et al., Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial. Epilepsia, 2014. 55(1):38-46.
  7. UCB Data on file
  8. Kenda, B. M., et al., Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity. Journal of Medicinal Chemistry, 2004. 47(3): 530-549.
  9. Gillard, M., et al., Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties. Eur J Pharmacol, 2011. 664(1-3):36-44.
  10. Fisher, R. S., et al., ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia, 2014. 55(4): 475-82.
  11. The Epilepsy Foundation. Who gets epilepsy? Accessed 21st July 2014 from http://www.epilepsy.com/learn/epilepsy-101/who-gets-epilepsy
  12. The Epilepsy Foundation. Types of seizures Accessed 21st July 2014 from

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