Navigation Links
Magnetic fields drive drug-loaded nanoparticles to reduce blood vessel blockages in an animal study
Date:4/19/2010

Scientists and engineers have used uniform magnetic fields to drive iron-bearing nanoparticles to metal stents in injured blood vessels, where the particles deliver a drug payload that successfully prevents blockages in those vessels. In this animal study, the novel technique achieved better results at a lower dose than conventional non-magnetic stent therapy.

Conducted in cell cultures and rats, the research is the latest in a series of studies at The Children's Hospital of Philadelphia demonstrating the feasibility of magnetically guided nanoparticles as a new delivery platform for a variety of possible therapeutic cargos: DNA, cells and drugs. The findings may set the stage for a new medical tool, called vascular magnetic intervention.

"This can become a major platform technology for delivering drugs and other agents to specific sites where they can produce benefits in diseased or injured blood vessels," said study leader Robert J. Levy, M.D., the William J. Rashkind Endowed Chair in Pediatric Cardiology at The Children's Hospital of Philadelphia.

The research appears in the Proceedings of the National Academy of Sciences, published online this week. Levy's group from Children's Hospital collaborated with engineers and scientists from Drexel University, Northeastern University and Duke University.

Levy's work introduces a new delivery system to an existing medical technologycatheter-deployed stents. Patients with heart disease commonly receive such stents, narrow metal scaffolds that widen a partly clogged blood vessel. These stents are often coated with antiproliferative drugs such as paclitaxel. Paclitaxel inhibits the accumulation of smooth muscle cells within the stent that cause an obstruction.

However, current drug-eluting stents have their limitations. They contain a fixed dose of medication, good for just one release. In a significant number of patients, reobstruction occurs. Levy's magnetically g
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Brown physicist discovers odd, fluctuating magnetic waves
2. Using magnetic toys as inspiration, researchers tease out structures of self-assembled clusters
3. Magnetic mixing creates quite a stir
4. Researchers design new graphene-based, nanomaterial with magnetic properties
5. Researchers design new graphene-based, nano-material with magnetic properties
6. Unexpectedly long-range effects in advanced magnetic devices
7. Nanophysicists find unexpected magnetic effect
8. Capture of nanomagnetic fingerprints a boost for next-generation information storage media
9. Stereotaxis Showcases Advancements for Remote Magnetic Ablations
10. New Publications Show Noninvasive Magnetic Resonance-Guided Focused Ultrasound to be a Potentially Safe, Effective Pain-Relieving Treatment for Bone Metastases
11. New process creates 3-D nanostructures with magnetic materials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Magnetic fields drive drug-loaded nanoparticles to reduce blood vessel blockages in an animal study
(Date:7/3/2015)... , July 3, 2015 ... "Lab for Open Innovation in Science", som ... . Søknadene sendes på nett, på  http://www.openinnovationinscience.at ... september 2015.  De to største ... til å undersøke nye forskningsspørsmål og kompleksiteten ...
(Date:7/2/2015)... Brooklyn, NY (PRWEB) , ... July 03, 2015 , ... Cuvettes have been used in ... book style catalog to find the cuvette they needed. As expected, this was a ... would order the wrong part because they were not able to navigate the complex catalog ...
(Date:7/2/2015)... GLASGOW, Scotland , July 2, 2015 ...   Bio-tech procurement company Amici Procurement has ... IOM) to help it move to Office 365. ... Procurement provides small to medium-sized companies in the ... with all aspects of the purchasing cycle to help ...
(Date:7/1/2015)... ... July 01, 2015 , ... It is now possible to separate two common ... emission computed tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas Jefferson ... scans and is believed to be the largest brain imaging study ever, will be ...
Breaking Biology Technology:Lansering av verdens første Open Innovation-program for utdanning av forskere 2Lansering av verdens første Open Innovation-program for utdanning av forskere 3New Cuvette E-Commerce Website Launched by FireflySci 2Biotech Procurement Company Moves to Office 365 with iomart 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4
... 8 InteKrin Therapeutics, Inc.,will present at the 27th ... Time on Tuesday, January 13, 2009, to be held ... Therapeutics, President and,CEO Denny Lanfear will present at the ... http://www.InteKrin.com ): , InteKrin Therapeutics ...
... 8 AcelRx Pharmaceuticals, Inc.,announced today it has ... In this new position, Dr. Skowronski will ... and providing medical input,and review of clinical development ... the company,s Chief Medical Officer. , ...
... Last 10 Years Helping Implement World Bank HIV/AIDS and ... that Dr. John Osika has joined the company as ... Dr. Osika, a board certified physician in the ... health expert with extensive experience working on HIV/AIDS and ...
Cached Biology Technology:InteKrin Therapeutics to Present at the 27th Annual JP Morgan Healthcare Conference on Tuesday, January 13 2Dr. John Stephen Osika, HIV/AIDS and Infectious Disease Expert, Joins Abt Associates 2
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
(Date:6/23/2015)... Research and Markets( ... "Body-Worn Temperature Sensors Market - Global Industry ... - 2020" report to their offering. ... global body-worn temperature sensors market. The global body-worn ... basis of types, care setting, patient demographic, applications ...
(Date:6/17/2015)... GERMANTOWN, Maryland , June 17, 2015 ... Produktlinie mit DNA-Tests verbessert den Analyseprozess und senkt Laborkosten ... Frankfurt Prime Standard: QIA) hat heute in den ... Investigator ® für die forensische ... Kits zur Erstellung genetischer Fingerabdrücke bieten eine integrierte Lösung ...
Breaking Biology News(10 mins):Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6
... impact of age on the growth rates of cellular populations, ... the growth of bacteria, and could provide new insights into ... appears in Evolution: International Journal of Organic Evolution , ... University of Tokyo. When bacterial cells age, their capacity ...
... New research from the Keck School of Medicine of ... damage to the liver caused by drugs like acetaminophen ... Tylenol, helps relieve pain and reduce fever. The over-the-counter ... flu remedies as well as prescription painkillers like Percocet ...
... Alberta, Canada Sept. 7, 2011: Not all trans fats ... nutrition labels in North America to reflect this, particularly when ... to a scientific review published in the latest edition of ... ruminant animals such as dairy and beef cattle are not ...
Cached Biology News:Scientists offer way to address 'age-old' questions 2Scientists offer way to address 'age-old' questions 3USC scientists identify key protein linked to acute liver failure 2Time to reboot thinking on trans fats -- natural trans fats from dairy and beef are good 2