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MacroChem Announces Michael Zasloff, M.D., Ph.D. Joins Company's Scientific Advisory Board
Date:10/17/2007

lecular genetics, and in 1981 was named Chief of the Human Genetics Branch of the National Institutes of Child Health and Human Development. In 1989 he left the NIH to become the Charles E.H. Upham Professor of Pediatrics and Genetics at the University of Pennsylvania School of Medicine and Chief of the Division of Human Genetics of the Children's Hospital of Philadelphia. In that same year (1989) he founded Magainin Pharmaceuticals (now Genaera) and served as Vice Chairman and Executive Vice President until 2001. Dr. Zasloff holds over forty patents, has been widely published, and has been the recipient of numerous awards. His current studies focus on the role of innate immunity in the setting of human small intestinal transplantation, and the pathways that control the expression of antimicrobial peptides in human health and disease.

"It is my pleasure to join the MacroChem team to resume the development of pexiganan," said Dr. Zasloff. The need for a topical therapy for infected diabetic foot ulcers remains more pressing than ever, both because of the increasing prevalence of diabetes, and the emergence of multidrug-resistant bacteria. Over the past several years numerous published reports have confirmed the importance of antimicrobial peptides in the natural control of human infections. In diseases like diabetes we believe these antimicrobial defenses fail, resulting in skin and soft tissue infection. As a potent broad spectrum antimicrobial peptide, pexiganan can rapidly kill the many types of microbes that infect the diabetic foot, and should not promote the appearance of resistant microbes."

Mr. DeLuccia further noted, "We believe pexiganan is a unique opportunity for MacroChem to broaden its development portfolio with a product that has already completed two Phase 3 clinical trials. It also fits our strategic focus and complements our lead product candidate, EcoNail(R) for treatment of nail fungus. EcoNail is currently in a fully enrolled Phase 2
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SOURCE MacroChem Corporation
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