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Machine Preservation Significantly Improves Kidney Transplant Survival Over 3 Years Compared to Traditional box of ice
Date:2/22/2012

sion offers significant improvements for 3-year graft survival in kidneys from these donors and is a real step forward in kidney transplantation."

About the trial

  • The Machine Preservation Trial was a landmark, investigator-driven study, run by an independent scientific steering committee across the Netherlands, Belgium and the German federal state of North Rhine Westphalia, in collaboration with the Deutsche Stiftung Organtransplantation and Eurotransplant International Foundation (the international organ exchange organisation for Austria, Belgium, Croatia, Germany, Luxembourg, The Netherlands and Slovenia) as the central trial assistance desk. Principal investigators were Rutger Ploeg (Oxford, United Kingdom and Groningen, The Netherlands), Andreas Paul (Essen, Germany) and Jacques Pirenne (Leuven, Belgium).
  • The study was the first large randomised, prospective trial to compare machine perfusion with traditional cold static storage.
  • Three-year follow-up data were collected on all 672 recipients of consecutive kidneys donated after brain death or after cardiocirculatory death in the main data set, as well as 164 recipients of kidneys donated after cardiocirculatory death in the extended data set. One kidney from each of the 336 pairs included was randomly assigned to machine perfusion, and the contralateral organ to cold storage.
  • Earlier 12 month results from the Machine Preservation Trial, also published in the New England Journal of Medicine, showed that in transplanted kidneys preserved and transported in the LifePort Kidney Transporter, the odds of experiencing a delay in recovery of kidney function were 43% lower, and that these kidneys were 48% less likely to fail within a year compared to those stored in the traditional box of ice.[5]

About the LifePortKidney Transporter

LifePort is a device that preserves a donated kidney before it is tra
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SOURCE Organ Recovery Systems
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