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Living cells behave like fluid-filled sponges
Date:1/7/2013

Animal cells behave like fluid-filled sponges in response to being mechanically deformed according to new research published today in Nature Materials.

Scientists from the London Centre for Nanotechnology (LCN) at UCL have shown that animal cells behave according to the theory of 'poroelasticity' when mechanically stimulated in a way similar to that experienced in organs within the body. The results indicate that the rate of cell deformation in response to mechanical stress is limited by how quickly water can redistribute within the cell interior.

Poroelasticity was originally formulated to describe the behaviour of water-saturated soils and has important applications in the fields of rock engineering and petro-physics. It is commonly used in the petroleum industry. Poroelastic models describe cells as being analogous to fluid-filled sponges. Indeed, cells are constituted of a sponge-like porous elastic matrix (comprising the cytoskeleton, organelles, and macromolecules) bathed in an interstitial fluid (the cytosol).

In this analogy, the rate at which the fluid-filled sponge can be deformed is limited by how fast internal water can redistribute within the sponge in response to deformation. This rate is dictated by three parameters: the stiffness of the sponge matrix, the size of the pores within the sponge matrix, and the viscosity of the interstitial fluid.

To study cellular responses, LCN scientists used cell-sized levers to apply rapid well-controlled deformations on the cell surface and monitored the temporal response of cells to these deformations. Close examination of the experimental results revealed that the rate of cellular deformation was limited by how rapidly water could redistribute within the cell interior. Experimental measurements indicated that this sponge-like behaviour of cells likely occurs during normal function of organs such as the lungs and the cardiovascular system.

Emad Moeendarbar
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Contact: Clare Ryan
clare.ryan@ucl.ac.uk
44-077-475-65056
University College London
Source:Eurekalert

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