Navigation Links
Key to aging immune system is discovered
Date:7/31/2014

unwinds double-stranded DNA so that the cell's genetic material can be duplicated and allocated to daughter cells later in cell division. In their study the stem cells were stressed by the loss of activity of this machine and as a result were at heightened risk for DNA damage and death when forced to divide.

The researchers discovered that even after the stress associated with DNA replication, surviving, non-dividing, resting, old stem cells retained molecular tags on DNA-wrapping histone proteins, a feature often associated with DNA damage. However, the researchers determined that these old survivors could repair induced DNA damage as efficiently as young stem cells.

"Old stem cells are not just sitting there with damaged DNA ready to develop cancer, as it has long been postulated" Passegu said.

But not all was well in the old, surviving stem cells. The molecular tags accumulated on genes needed to make the cellular factories known as ribosomes. The ribosomes make all the cell's proteins. Passegu will further explore the consequences of reduced protein production as part of her ongoing research.

"Everybody talks about healthier aging," Passegu added. "The decline of stem-cell function is a big part of age-related problems. Achieving longer lives relies in part on achieving a better understanding of why stem cells are not able to maintain optimal functioning."

Passegu hopes that it might be possible to prevent declining stem-cell populations by developing a drug to prevent the loss of the helicase components needed to faithfully unwind and replicate DNA, thereby avoiding immune-system failure.


'/>"/>

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks
2. Fastec Imaging Introduces the First High Speed Camcorder
3. Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion
4. Aging Population & Rising Incidence of Chronic Diseases to Drive the Global Mesenchymal Stem Cells Market, According to New Report by Global Industry Analysts, Inc.
5. Latest Technologies for Life-saving Applications on the Program at SPIE Medical Imaging
6. Studies Show Pterostilbene Shows Promise for Anti-Aging and Maintaining Healthy Brain
7. Founders Fund Backs Nanotronics Imaging
8. The Houston Methodist Human Performance Lab Launches Innovative Study on Triathletes, Investigating the Effects of Aging and Training Variables on Triathlon Performance
9. Smart Imaging Technologies and InvitroCue Team Up to Bring Digital Pathology to Asia
10. New venue, new conference, new courses, new technologies for Electronic Imaging 2014
11. Scientists accelerate aging in stem cells to study age-related diseases like Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Key to aging immune system is discovered
(Date:10/31/2014)... Following the successful launch of On Demand ... introduce its new product and demonstrate its potential to ... in September, Formedix On Demand Services is the first ... tools. For the first time, these market-leading tools can ... Formations – a revolutionary new token-based payment system – ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Brady ... identification solutions, today announced a new video testimonial ... labels. In the video, a research technician at the ... it comes to labeling and storing hundreds of thousands ... has benefitted her research. , “At Brady, we design ...
(Date:10/31/2014)... , Oct. 31, 2014  Tavistock Development ... by Tavistock Group, celebrated the groundbreaking of the ... City. The 92,000-square-foot, three-story facility ... Central Florida designed specifically for life ... the heart of the 650-acre Lake Nona Medical ...
(Date:10/30/2014)... , October 30, 2014 ... Holdings Inc. (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: ... ), Synthetic Biologics Inc. (NYSE MKT: SYN), and Ironwood ... companies can be accessed at: http://investor-edge.com/register . ... ended at 4,549.23, down 0.33%, the Dow Jones Industrial ...
Breaking Biology Technology:Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Brady Debuts New Lab Label Testimonial Video 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5
... Calif., Feb. 4 Arryx, Inc.,announced the addition ... Holographic Optical Trapping ("HOT") product line. The HOTkit,Complete ... events, and now, through the power of light, ... The HOTkit Complete was unveiled February 4 ...
... HORSHAM, Pa., Feb. 4 Centocor, Inc. announced ... (CNTO 1275),has been accepted for review by the ... of adult patients with chronic moderate to severe ... with a novel,mechanism of action that targets the ...
... HAVEN, Conn., Feb. 4 VION,PHARMACEUTICALS, INC. (Nasdaq: ... the Company,s senior management team as Vice President,Medical., ... pleased,to have Bill Hahne joining Vion in medical affairs. ... will be extremely useful to our,efforts to file a ...
Cached Biology Technology:Arryx Launches HOTkit(TM) Complete for Dynamic, Scientific Manipulation of Microscopic Elements 2Arryx Launches HOTkit(TM) Complete for Dynamic, Scientific Manipulation of Microscopic Elements 3Centocor Announces Ustekinumab Biologic License Application Accepted for Filing by FDA 2Centocor Announces Ustekinumab Biologic License Application Accepted for Filing by FDA 3Vion Pharmaceuticals Adds William Hahne, M.D. to Senior Management Team 2Vion Pharmaceuticals Adds William Hahne, M.D. to Senior Management Team 3
(Date:10/29/2014)... open for the Society of Interventional Radiology,s ... is the one place where interventional radiologists, ... care professionals can come together to find ... being presented, discussed and tested. , ... image-guided medicine, SIR 2015 will feature essential ...
(Date:10/29/2014)... and industrial products are in the environment – and ... them, scientists have yet to determine whether they cause ... doing that by estimating which substances people are exposed ... the ACS journal Environmental Science & Technology . ... risks to human health of any given substance depend ...
(Date:10/29/2014)... LANSING, Mich. – As bodies decompose, their types ... the clues they provide could mean the difference ... , Michigan State University is using a more ... help Detroit death-scene investigators examine these changing populations. ... as geographical location of death, gender, race, socioeconomic ...
Breaking Biology News(10 mins):SIR 2015: Interventional radiology shapes tomorrow's medicine 2MSU partners with Detroit to investigate death scenes 2
... of California, San Diego has discovered a molecule in ... or Bt toxin--a pesticide produced by bacteria and widely ... to ward off insect pests. , Their findings should ... prevent insects, which the researchers believe also possess the ...
... scientific world has accepted for more than 100 ... by their grandparents, bypassing genetic abnormalities carried by ... have hidden templates containing genetic information from the ... offspring, even though the traits aren't evident in ...
... to coax mouse stem cells to transform themselves into fat ... naturally do in the body. , While other studies have ... cells never completely functioned in the same way they do ... biologic components that all cells require to do their work. ...
Cached Biology News:UCSD discovery may help extend life of natural pesticide 2UCSD discovery may help extend life of natural pesticide 3Plants defy Mendel's inheritance laws, may prompt textbook changes 2Plants defy Mendel's inheritance laws, may prompt textbook changes 3Tiny scaffolding allows stem cells to become working fat cells 2Tiny scaffolding allows stem cells to become working fat cells 3
... A simultaneous dual parameter assay ... poly caspase activity. Active caspases are ... peptide inhibitors, which are cell-permeable, non-cytotoxic ... caspases within the cells. At the ...
... Mouse EL-4 cells were cultured in DMEM ... In order to keep the antigens in ... The cells are arrayed on a 12-well ... surface specifically treated to enhance cellular attachment and ...
... The CopyControl™ vector can be induced ... These vectors provide the stability of single-copy ... cosmids or other cloning vectors. The kits ... (ligation reagents, insert size screening system) necessary ...
... induced prior to DNA purification increasing DNA ... single-copy BACs with the high yields associated ... kits provide the linearized vector and associated ... necessary to create a 10X human BAC ...
Biology Products: