Navigation Links
JCI early table of contents for Aug. 15, 2013
Date:8/16/2013

Biomarkers predict time to ovarian cancer recurrence

Ovarian cancer often remains undetected until it is at an advanced stage. Despite positive responses to initial treatment, many patients are at risk of tumor recurrence. A multitude of genetic markers have been implicated in ovarian cancer prognosis. However, the genetic testing required is not practical or affordable in a clinical setting. In this issue of the Journal of Clinical Investigation, Roel Verchaak and colleagues at the MD Anderson Cancer Center identify protein biomarkers that are predictive for time of ovarian cancer recurrence and develop a PRotein-driven index of OVARian cancer (PROVAR). Using PROVAR, the authors were able to discriminate between patients with high and low risk of cancer recurrence, as well as short-term and long-term survival prognosis. In combination with genetic diagnosis, analysis of protein biomarkers may be useful in predicting outcome and determining a treatment plan for ovarian cancer patients.

TITLE: Predicting Time to Ovarian Carcinoma Recurrence Using Protein Markers

AUTHOR CONTACT: Roel G.W. Verhaak
MD Anderson Cancer Center, Houston, TX, USA
Phone: 7135632293; E-mail: RVerhaak@mdanderson.org

View this article at: http://www.jci.org/articles/view/68509?key=d03afe0843e018bcf8a0


A molecule involved in development of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is characterized by poor airflow due to the breakdown of lung tissue, mucus accumulation and airway dysfunction. Development of COPD is most commonly associated with smoking tobacco, however, it also occurs after acute respiratory infections such as influenza. It is unclear how prior lung disease leads to COPD. In th
'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Netsmart Clients to Receive Nearly $2 Million in Meaningful Use EHR Incentive Payments
2. Access BridgeGap Ventures to Focus on Early-Stage Therapeutic Opportunities
3. VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer
4. Sequenom Announces 2011 Operational Highlights and Early 2012 Outlook
5. CSL Behring Study Confirms Early Treatment with Berinert® Provides Faster Resolution of Acute Hereditary Angioedema Symptoms
6. Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity
7. Butamax Early Adopters Group surpasses capacity targets with addition of Big River; Membership represents 11 production facilities and nearly 900 million gallons of ethanol capacity
8. Researchers peek at the early evolution of sex chromosomes
9. Discuss Early Results of the DIAN Trial at CBIs 6th Annual Alzheimers Drug Development Summit
10. Early career distinction: Prestigious award recognizes physicists work in electron dynamics
11. JCI early table of contents for Sept. 4, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... 2015 Whitehouse Laboratories is excited to ... term partnership with PTI Inspection Systems. Whitehouse Labs and ... with custom-tailored method development and validation programs using ... The agreement includes a more formal program that facilitates ... lines. This enables a more effective team approach, especially ...
(Date:5/28/2015)... In two different WPC forums , ... will present the company’s unique approach to developing technologies ... he will describe Asymmetrex ’s innovation in integrating ... to produce the first-ever technology for quantitative monitoring of ... in culture. When leading an interactive breakout discussion ...
(Date:5/27/2015)... , May 26, 2015 ... announced the addition of Jain PharmaBiotech,s new ... and Companies" to their offering. ... molecular diagnostics technologies that will play an ... health, pharmaceutical industry, forensics and biological warfare ...
(Date:5/27/2015)... , May 27, 2015 /CNW/ - CQDM, Brain Canada ... to $8.5M to six (6) multi-disciplinary and multi-provincial research ... within their Focus on Brain strategic initiative. To this ... involved as in-kind contributions. This exciting announcement was made ... for Neuroscience in the presence of Inez Jabalpurwala, President ...
Breaking Biology Technology:Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 2Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 2Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 4Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 5Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 6Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 7Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 8Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 9Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 10
... Wis. - This summer, venture investors deployed more than ... that may bode well for improving on the state's 2005 ... conclusions from one quarter of investment activity, the number could ... a growing base of capital in 2006. , ,"With the ...
... theft (IDT), yet unless you have been a victim, few ... figure is that over half of the 10 million new ... or other entity (not-for-profit or local, state, or federal government). ... or more federal and state laws to implement measures, policies, ...
... Two news stories in the past week have stirred ... the state competing in the global economy, as CDW ... a low-talent, high-tax backwater, as RedPrairie executive John Jazwiec ... to Jazwiec when he says he has trouble recruiting ...
Cached Biology Technology:Summer venture investments total $18 million for Wisconsin start ups 2Summer venture investments total $18 million for Wisconsin start ups 3Summer venture investments total $18 million for Wisconsin start ups 4Identity theft: The business time bomb 2Identity theft: The business time bomb 3Identity theft: The business time bomb 4Who's right about Wisconsin - CDW or RedPrairie? 2Who's right about Wisconsin - CDW or RedPrairie? 3
(Date:5/11/2015)... RYE, N.Y. , May 11, 2015 ... company, announced the start of a new Phase III ... effect of its novel formulation, CM-AT, on all children ... results of its FDA Phase III double blinded clinical ... who had low levels of the digestive enzyme chymotrypsin. ...
(Date:5/5/2015)... OXFORD, Conn. , May 5, 2015, NXT-ID, ... biometric authentication company focused on the growing mobile commerce market, ... the Company,s Chief Technology Officer, is presenting  at CARTES SECURE ... May 5-7, 2015. The three-day conference ... session David is speaking in is themed Global Fraud: ...
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... Most people who carry a genetic mutation for a ... phenomenon that has puzzled scientists since the first genetic ... The Feinstein Institute for Medical Research have figured out ... the disorder they have an additional lesion that ...
... PA, 5 August 2009 - It is important to ... to be resilient under conditions of extreme stress, such ... Dr. Charles A. Morgan III and his colleagues ... PTSD have worked closely with collaborators at the Special ...
... flies and other insects that encounter nanomaterial "hot spots," or ... and transport nanoparticles on their bodies, transferring the particles to ... carbon nanoparticles barely 1/5,000th the width of a human ... Environmental Science & Technology , a semi-monthly journal. ...
Cached Biology News:Abnormal brain circuits may prevent movement disorder 2Hormone levels contribute to stress resilience 2
... The Multiple Species Tissue Array (MSTA) slides were ... cells and tissues from multiple species. Tissue ... each MSTA slide which can then be treated ... immunohistochemistry, or in situ hybridization. ...
... Clear yellow solution. ... 0.01% thimerosal, and other ... filtered. Diluent formulated to ... peroxidase antibody conjugates at ...
... cells-directed transfection reagent : jetPEI-RGD ... which allows targeted efficient transfection ... cells. Integrins are adhesion molecules ... adhesion processes. Many integrins, including ...
...
Biology Products: