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Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting
Date:4/20/2009

antisense technology and adds to our previously published work using antisense to target different classes of RNAs, including microRNAs and other non-coding RNAs. We and our collaborators have shown that antisense inhibition of non-coding RNAs can impact splicing patterns in cells to modulate the expression of multiple proteins that may be involved in disease," said C. Frank Bennett, Ph.D., Senior Vice President of Research at Isis Pharmaceuticals. "Furthermore, the work of our team on STAT5 provides yet another oncology target with the potential for anti-tumor activity. We believe that antisense drugs have pharmaceutical properties that make them attractive therapeutics for cancer, and we are expanding our efforts in cancer to include new targets and new approaches."

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Isis and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microRNA therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are commercializing. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,600 issued patents worldwide. Additional information about Isis is available at www.isispharm.com.

This press release includes forward-looking statements regarding Isis' business, its drug discovery an
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SOURCE Isis Pharmaceuticals, Inc.
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