Navigation Links
Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy
Date:5/17/2013

MIAMI, May 17, 2013 /PRNewswire/ -- Insero Health, Inc., a company developing natural compounds to address unmet medical needs in epilepsy and related neurological disorders, is today reporting top-line results from a Phase Ib trial of its lead compound INS001 in patients with drug-resistant epilepsy.  The data are being presented at the AntiEplileptic Drug and Device Trials (AED) Xll meeting by Dr. Steven Schachter , Harvard Medical School epileptologist and Chairman of Insero's Scientific Advisory Board.  In this study, INS001 appeared safe and well tolerated.

INS001 is a naturally occurring compound that has shown promising activity in multiple preclinical epilepsy models.  Insero researchers believe that INS001 exerts its anti-epileptic effects through a unique combination of mechanisms: it is both a potent acetylcholinesterase inhibitor and an NMDA-receptor antagonist.  The compound has previously demonstrated good safety and signs of therapeutic activity in a Phase II trial in Alzheimer's disease, as well as in preclinical models of multiple sclerosis and neuropathic pain.

The Phase I trial was a single-center, inpatient, open-label, rapid dose escalation study in patients with drug-resistant epilepsy.  INS001 was safe and well tolerated at doses expected to be therapeutic, and increased cardiac parasympathetic tone and electrical stability were observed.

Dr. Schachter noted, "The positive safety demonstrated in this first trial of INS001 in drug-resistant epilepsy is a step forward in the clinical development of this therapy as a potential new treatment option for patients with epilepsy whose seizures are inadequately treated today."

Insero expects to initiate a Phase II proof of principle trial in patients with drug-resistant epilepsy by early next year.

Epilepsy affects about three million people in the U.S. and over 50 million people
'/>"/>

SOURCE Insero Health, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013
2. Best Practices for Tracking Tissue in the Healthcare Supply Chain, Webinar Hosted by Xtalks
3. Cambrex To Present At UBS Global Healthcare Conference
4. Ampio Pharmaceuticals Announces Participation at the UBS Global Healthcare Conference
5. Orexigen Therapeutics to Present at the Bank of America Merrill Lynch 2013 Health Care Conference
6. ViroPharma To Participate In Two May Healthcare Investor Conferences
7. PrimeraDx Featured in the Goldman Sachs Healthcare Research Teams GS Emerging Healthcare Series
8. Sangamo BioSciences Announces Presentation at the Bank of America Merrill Lynch 2013 Health Care Conference
9. Neurocrine Biosciences To Present At The Bank of America Merrill Lynch 2013 Health Care Conference
10. CellHealth Institute is Named 2013 Edison Award Winner
11. AtheroNova Announces Approval for Phase 1 by the Russian Ministry of Healthcare with Commencement of Human Trials Imminent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 31, 2014 The report "Offshore Support ... Vessel, Platform Supply Vessels, Multi-Purpose Service Vessel, Crew Boats, ... - Global Trends & Forecast to 2018", defines and ... forecasting of the global revenue. , Offshore support vessel ... in 2013 to $ 91,228.8 Million by 2018, with ...
(Date:10/31/2014)... , October 31, 2014 Huge ... barometer of future pharma industry health, analysis and forecasting   ... Live, celebrates the closing of its most successful show ... attendees and 2,500 exhibitors. Held this year in ... makers and key players from 140+ countries representing every ...
(Date:10/31/2014)... 31, 2014 Having access to safe ... uphill battle in many corners of the globe. It’s ... community in northwestern Bolivia where many have been sickened ... from Fairfield University’s School of Engineering has been working ... Campesina (UAC), “the united college for the peasants.” A ...
(Date:10/31/2014)... London, UK (PRWEB) October 30, 2014 Caustic ... salts, epoxy resins and polycarbonates. At present, China takes lead ... , Dow, which possesses a number of facilities in ... player in the world caustic soda market in terms of ... is forecast to grow on average by 3% per year ...
Breaking Biology Technology:Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 2Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 3Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 4CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 2CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 3CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 4CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 5CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 6Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3China to Dominate Caustic Soda Market Through 2018, Says Merchant Research & Consulting in Its New Study 2
... 14 Bionovo, Inc.,(Nasdaq: BNVI ) announced ... Board of Directors. Mr. Drapeau has extensive financial,management ... "We are quite excited to have access to ... CEO. "Lou is particularly well versed,in the unique ...
... CALGARY, March 14 /PRNewswire-FirstCall/ - SemBioSys Genetics ... portfolio of therapeutic,proteins for metabolic and cardiovascular ... an important step forward in the,commercialization of ... an,exclusive global alliance with Bioriginal Food and ...
... Express, the advance online publication of the journal ... mark an important step toward understanding a longstanding ... presented their findings at the annual meeting of ... problem the physicists addressed is how a fundamental ...
Cached Biology Technology:Louis Drapeau Joins Bionovo's Board of Directors 2Louis Drapeau Joins Bionovo's Board of Directors 3SemBioSys' GLA Partner Enters Strategic Alliance for the Sales and Marketing of GLA-Rich Safflower Oil 2SemBioSys' GLA Partner Enters Strategic Alliance for the Sales and Marketing of GLA-Rich Safflower Oil 3Physicists discover how fundamental particles lose track of quantum mechanical properties 2Physicists discover how fundamental particles lose track of quantum mechanical properties 3
(Date:10/31/2014)... WCS study confirms that endangered musk deer still live ... sighting, Species targeted by poachers: Musk deer scent glands ... the October issue of the journal Oryx ... 60 years after its last confirmed sighting, a strange ... forested slopes of northeast Afghanistan according to a research ...
(Date:10/31/2014)... source that emits over a wide part of the ... currently being built in Lund, Sweden. The MAX IV ... team putting together its component parts in a storage ... of just a few hundred metres. Nevertheless, if these ... class of experiments that require source brightness and transverse ...
(Date:10/31/2014)... Haven, Conn. – Geologists are letting the air out of ... Earth. , Scientists have long speculated as to why animal ... surface. Animals began to prosper at the end of the ... about the billion-year stretch before that, when most researchers think ... the air wasn,t so great then, after all. , In ...
Breaking Biology News(10 mins):Strange, fanged deer persists in Afghanistan 2A new generation of storage -- ring 2Lack of oxygen delayed the rise of animals on Earth 2
... is available in German . , Metabolomics aims ... cell or a tissue. The exponents of bioinformatics analyzed data ... healthy and diabetic mice. In each case, a subgroup of ... more than 800 metabolites were quantitatively determined in a blood ...
... flower and plant growers know all too well that ... and deterring healthy growth of potted ornamental plants. To ... expensive practice of paying workers to hand-weed containers. Some ... on the wide range of plant species produced in ...
... July/August 2008 issue of BioScience are as follows: ... Joan Burnside, and Scott V. Edwards. , An increasingly broad ... expanding what has been learned from studies based on the ... of the whole class. ***************, Penguins as Marine ...
Cached Biology News:Healthy or diseased? 2Ethanol byproduct produces green results 2BioScience tip sheet July/August 2008 2BioScience tip sheet July/August 2008 3
Prepared by multi-temperature ethanol fractionation with extensive charcoal treatment and dialysis.• Assay: ≥ 95 % (HPCE)• pH ~5.2 (10 mg/mL in 0.15 M NaCl)...
... DAPI (4,6-diamidine-2-phenylindole, dihydrochloride) is a ... nucleus blue in color. The ... contrast to red fluorochromes such ... or R-Phycoerythrin. DAPI can be ...
... (CYP450) metabolite postulated to play an autacoid ... In rat cerebral microvessels, 20-HETE is a ... is excreted mainly as the glucuronide conjugate. ... in human urine) is about 10-fold lower ...
Rabbit polyclonal to Quinaldic Acid ( Abpromise for all tested applications). Antigen: Synthetic peptide Quinaldic Acid conjugated to a protein carrier....
Biology Products: