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IFRS Information - First Half of 2007
Date:9/13/2007

$'M $'M %

________ ___________ ___________

3TC 74.5 77.8 -4

ZEFFIX 19.4 16.1 +20

Others 29.6 27.5 +8

________ ____________ ___________

Total 123.5 121.4 +2

________ ____________ ___________

3TC

Royalties from sales of 3TC for the six months to June 30, 2007 were $74.5 million (2006: $77.8 million), a decrease of 4% compared to the same period in 2006. The impact of foreign exchange movements has contributed 4% to the reported growth. Excluding foreign exchange movements the royalty income has declined 8% compared to the same period in 2006.

Shire receives royalties from GSK on worldwide 3TC sales. GSK's worldwide sales of 3TC for the six months to June 30, 2007 were $554 million, a decrease of 7% compared to the same period in 2006 (2006: $595 million). The nucleoside analogue market for HIV has continued to grow, however competitive pressures within the market have increased, leading to a decline in 3TC sales.

ZEFFIX

Royalties from sales of ZEFFIX for the six months to June 30, 2007 were $19.4 million (2006: $16.1 million), an increase of 20% compared to the same period in 2006. The impact of foreign exchange movements has contributed 10% to the reported growth. Excluding foreign exchange movements there has been an increase of 10% compared to the same period in 2006.

Shire receives royalties from GSK on worldwide ZEFFIX sales. GSK's worldwide sales of ZEFFIX for the six months to June 30, 2007 were $167 million, an increase of 19% compared to the same period in 2006 (2006: $140 million). This increase was primarily due to strong growth in the Chinese, Japanese and Korean markets.

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SOURCE Shire plc
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