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IFRS Information - First Half of 2007
Date:9/13/2007

terialize, Shire results could be materially affected. The risks and uncertainties include, but are not limited to, risks associated with: the inherent uncertainty of pharmaceutical research, product development, manufacturing and commercialization; the impact of competitive products, including, but not limited to the impact of those on Shire's Attention Deficit and Hyperactivity Disorder ("ADHD") franchise; patents, including but not limited to, legal challenges relating to Shire's ADHD franchise; government regulation and approval, including but not limited to the expected product approval date of INTUNIV(TM) (guanfacine) extended release (ADHD); Shire's ability to secure new products for commercialization and/or development; Shire's ability to benefit from its acquisition of New River Pharmaceuticals Inc.; the successful development of JUVISTA(R) (Human TGFb3) and other risks and uncertainties detailed from time to time in Shire plc's filings with the Securities and Exchange Commission, particularly Shire plc's Annual Report on Form 10-K for the year ended December 31, 2006.

The following are trade marks of Shire plc or companies within the Shire Group, which are the subject of trade mark registrations in certain territories.

ADDERALL XR(R) (mixed salts of a single entity amphetamine)

ADDERALL(R) (mixed salts of a single entity amphetamine)

CALCICHEW(R) range (calcium carbonate with or without vitamin D3)

CARBATROL(R) (carbamazepine extended-release capsules)

DAYTRANA(TM) (methylphenidate transdermal system)

ELAPRASE(TM) (idursulfase)

FOSRENOL(R) (lanthanum carbonate)

GENE-ACTIVATED(TM)

INTUNIV(TM) (guanfacine extended release)

LIALDA(TM) (mesalamine)

MEZAVANT(R) (mesalazine)

REMINYL(R) (galantamine hydrobromide) (UK and Republic of Ireland)

REMINYL XL(TM) (galantamine hydrobromide) (UK and Republic of Ireland)

REPLAGAL(R) (agalsidase alfa)

VYVANSE(TM) (lisdexamfetamin
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SOURCE Shire plc
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