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IFRS Information - First Half of 2007
Date:9/13/2007

a percentage of product sales, SG&A expenses were 66% (2006: 60%).

6 months to June 30, 2007 2006(1) Change

$'M $'M %

____________ ____________ ___________

Sales costs 154.2 108.5 +42

Marketing costs 195.6 175.4 +12

Other SG&A costs 122.3 103.1 +19

____________ ____________ ___________

472.1 387.0 +22

Depreciation, amortization and

goodwill impairment(2) 161.5 48.2 n/a

____________ ____________ ___________

Total SG&A costs 633.6 435.2 +46

____________ ____________ ___________

(1) 2006 amounts have been reclassified to conform to the 2007

presentation.

(2) Excludes depreciation from manufacturing plants of $2.6 million

(2006: $2.2 million) which is included in cost of product sales.

The increase in sales and marketing costs included the impact of the following:

- An increase in the ADHD sales force to promote VYVANSE;

- The cost of the new GI sales force in the US; and

- The launches of DYNEPO, LIALDA and VYVANSE.

For the six months to June 30, 2007 SG&A expenses included a charge of $15.2 million in respect of share based compensation (2006: $12.4 million), representing 2% of product sales (2006: 2%).

Depreciation, amortization and goodwill impairment (included in selling, general and administrative expenses)

The depreciation charge for the six months to June 30, 2007 was $22.2 million (2006: $16.3 million). The increase in depreciation follows investment in Shire's infrastructure to support the continuing growth
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SOURCE Shire plc
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