Navigation Links
Human muscle stem cell therapy gets help from zebrafish
Date:11/7/2013

lanted into a mouse, the human iPS-derived muscle cells also contributed to muscle repair, offering early promise that this protocol could provide a route to muscle stem cell therapy in humans.

The interdisciplinary, cross-laboratory collaboration between Zon, Wagers, and Kahn highlights the advantage of open exchange between researchers. "If we had done this screen directly on human iPS cells, it would have taken at least 10 times as long and cost 100 times as much," said Wagers. "The zebrafish gave us a big advantage here because it has a fast generation time, rapid development, and can be easily and relatively cheaply screened in a culture dish."

"This research demonstrates that over 300 million years of evolution, the pathways used in the fish are conserved through vertebrates all the way up to the human," said Wagers' fellow HSCRB professor Leonard Zon, chair of the Harvard Stem Cell Institute Executive Committee and director of the stem cell program at Boston Children's Hospital. "We can now make enough human muscle progenitors in a dish to allow us to model diseases of the muscle lineage, like Duchenne muscular dystrophy, conduct drug screens to find chemicals that correct those disease, and in the long term, efficiently transplant muscle stem cells into a patient."

In a similar biomedical application, Kahn, who is chief academic officer at the Joslin, plans to apply the new ability to quickly produce muscle stem cells for diabetes research. His lab will generate iPS-derived muscle cells from people who are at risk for diabetes and people who have diabetes to identify alterations that lead to insulin resistance in the muscle.

Going forward, Zon plans to apply this platform of cross-species discovery to other stem cell lines, including those involved in blood and eye development. "We have a new system to use to study tissue development, and it's not just muscle that can be studied, every single organ can be studied in the
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-495-7821
Harvard University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Integrated 3-D Imaging Facilitates Human Face Transplantation
2. Roche NimbleGen and BGI Develop Advanced MHC Region Capture Technology for Human Disease and Biomedical Research
3. Singapore scientists lead human embryonic stem cell study
4. AFFiRiS AG Invests Into Human Capital - Chief Business Officer Recruited
5. ReproCELL Licensed Commercialization Right on Human iPS Cell Derived Hepatocytes - Expected Launch in Q2 2012
6. Cepheid Welcomes Senior Vice President of Human Resources
7. deCODE Genetics, in Collaboration with Academic Colleagues, Discovers Three Variants in the Sequence of the Human Genome that Affect the Risk of Thyroid Cancer
8. Foundation for Angelman Syndrome Therapeutics (FAST) Funds Human Clinical Trial
9. Successful human tests for first wirelessly controlled drug-delivery chip
10. First successful human results achieved: Implantable wireless microchip drug delivery device
11. Human Pheromone Sciences Voluntarily Files With SEC for Termination of Registration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... 2015   Neuraltus Pharmaceuticals, Inc. , a privately-held ... drugs to treat neurodegenerative diseases such as amyotrophic ... G. Miller , M.D., Director of the Forbes Norris ... Medical Center in San Francisco, has been awarded a ... to help fund a Phase 2 clinical study ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today ... Convention in Philadelphia, PA. , The presentation took place on Tuesday, June ... plans for the development of APX3330 for the treatment of pancreatic cancer. A ...
(Date:6/30/2015)... 30, 2015 /PRNewswire/ - Resverlogix Corp. ("Resverlogix") (TSX:RVX) ... of Resverlogix have approved the resolutions relating to: ... of 5,600,000 units at a price of $2.67 ... being comprised of one common share and 0.075358 ... approximately CAD$15 million; and (ii) the amendment to ...
(Date:6/30/2015)... San Francisco, CA (PRWEB) , ... June 30, ... ... in FMT Patients , Study will provide new insights on mechanics of fecal ... announced a new partnership to study the microbiome of patients undergoing fecal microbiota ...
Breaking Biology Technology:Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3
... venture capital firm, hopes to make waves in ... technology companies. Also, state Assembly Republicans moved to ... studies that require destroying embryos, and the state ... Original air date: Saturday, April 16, 2005 ...
... featured speaker at the Digital Healthcare Conference 2005 ... decade, technology applied to medical records and other information has ... to more common usage. At the Marshfield Clinic , ... hands by the time medical informatics associations and journals began ...
... comes to flexible work practices women are the proverbial canaries ... many corporate career tracks is any indication, the air must ... " On Ramps and Off Ramps: Keeping Talented Women on ... The Center for Work-Life Policy and Carolyn Buck Luce of ...
Cached Biology Technology:Carl Christensen says Marshfield Clinic's history gives it an IT edge 2Carl Christensen says Marshfield Clinic's history gives it an IT edge 3Carl Christensen says Marshfield Clinic's history gives it an IT edge 4Are women opting out or shut out from career tracks? 2Are women opting out or shut out from career tracks? 3Are women opting out or shut out from career tracks? 4
(Date:6/23/2015)... June 23, 2015   MedNet Solutions , ... the entire spectrum of clinical research, is pleased ... ™ , the company,s intuitive, flexible and affordable ... Silver 2015 Stevie® Award by the American ... Services Website category.  The American Business Awards are ...
(Date:6/23/2015)... 2015   Valencell, a leader in ... a recent study that illustrates its PerformTek biometric ... activity. In a study conducted at Valencell,s Biometric ... the Apple Watch against a chest strap – ... activity. The study demonstrated that Valencell,s biometric technology ...
(Date:6/18/2015)... 18, 2015 This report analyzes the worldwide ... following Product Segments, which includes Immunoassay Analyzers and Reagents: ... Radio Immunoassay Systems, and Nephelometric Immunoassay Systems. The report ... Canada , Japan , ... Latin America , and Rest of ...
Breaking Biology News(10 mins):MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
... indirectly via the release of melatonin, which implicates ... and the fasting glucose level. The finding could ... far beyond the primarily symptomatic therapy approaches to ... Diabetes mellitus and diabetes-associated late complications are among ...
... Wis. Jan. 12, 2009 The 2009 winners ... are Prasad Adusumilli, M.D. and Lee Goodglick, Ph.D. The ... pleural invasion and the role of estrogen in lung ... surgeon specializing in lung cancer at Memorial Sloan-Kettering Cancer ...
... Research published today reveals the major influence of fish on ... the health of coral reefs and other marine life. ... UK, US and Canada, could help solve a mystery that ... 2009) in Science , the study provides new insights ...
Cached Biology News:Is there a relationship between sleep-wake rhythm and diabetes? 2National Lung Cancer Partnership and LUNGevity Foundation announce 2009 grant recipients 2Fish guts explain marine carbon cycle mystery 2Fish guts explain marine carbon cycle mystery 3
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. It can incubate up to ...
... nucleotide structure called a ?cap? is ... naturally-occurring eukaryotic mRNAs and many viral ... a portion of the GTP present ... results in the synthesis of transcripts ...
... A modified nucleotide structure called ... 5?-end of most naturally-occurring eukaryotic mRNAs ... Cap Analog for a portion of ... vitro transcription reaction results in the ...
This Dedicated 18" X 18" (45.7 X 45.7 cm.) shaker platforms are optimized for a particular flask clip size. Dedicated platforms come fully loaded with flask clips....
Biology Products: