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Highest Genomic Replikin Counts Found in Antibiotic-Resistant Bacteria
Date:3/14/2013

to assume that this was a general genomic structural property of resistance in bacteria. However upon Replikins Analyses of 123,704 genomic sequences from several pathogenic bacteria published in Pubmed, the unexpected discovery was made that when bacterial resistance develops, for example in all six of the above named bacteria of concern, there is a marked increase in the genomic Replikin®Counts (number of genomic Replikins per 100 amino acids) (p<0.001). Replikin®Counts of 0.1 to 4.0 were found in antibiotic-sensitive bacteria; antibiotic-resistant bacteria isolates had Replikin®Counts greater than 4.0, which ranged from 4.1 to 50. Thus as the resistance to antibiotics of that bacterial population increased, the percent of Replikin®Counts in that bacterial population increased.

As new Replikins are added to or disappear from the genome during bacterial evolution, certain individual Replikins remain conserved for decades, making long-acting vaccines possible (3,4). This shared genomic structural property shared by different antibiotic-resistant bacterial strains presents a new platform in bacterial genomic structure for specific early diagnosis, vaccines, and therapies. Effective Replikins vaccines have been synthesized more cheaply than the cost of biological vaccines (10 cents vs 11 dollars), and in 7 days rather than 8 months, and by solid phase synthesis in virtually unlimited amounts, rather than only approximately 1.25 billion doses in 8 months as in the 2009 H1N1 pandemic; lacking the potential for side effects due to biological contaminants, and shipped freeze-dried without refrigeration.

Another consequence of this finding in the genomes of infectious diseases is the ability for the first time to predict outbreaks in advance, providing time to respond well in advance of the outbreak.  Before this work on bacteria, earlier studies by our companies on viruses, including influenza, found that when the virus genomes c
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