Navigation Links
Handheld probe shows great promise for oral cancer detection

A team of American researchers have created a portable, miniature microscope in the hope of reducing the time taken to diagnose oral cancer.

The probe, which is around 20 cm long and 1 cm wide at its tip, could be used by doctors to diagnose oral cancer in real-time or as a surgical guidance tool; dentists could also use it to screen for early-stage cancer cells.

The probe has been presented today, Friday 27 April, in IOP Publishing's Journal of Micromechanics and Microengineering, and has shown good agreement with images of oral cancers obtained using conventional, much slower techniques at the University of Texas Health Science Centre at San Antonio, TX.

Historically, the death rate associated with oral cancer is particularly high; not because it is hard to discover or diagnose, but due to the cancer being routinely discovered late in its development.

Lead author of the study Dr John X J Zhang at the University of Texas at Austin said: "Today, that statement is still true, as there isn't a comprehensive programme in the US to opportunistically screen for the disease; without that, late stage discovery is more common."

The probe uses a laser to illuminate areas of the sample and can view beneath the surface of tissue, creating full 3D images. It can also take a series of images and layer them on top of each other, much like the tiling of a mosaic, giving a large overall field-of-view.

The key component of the probe is a micromirror. Micromirrors have previously been used in barcode scanners and fibre optic switches and are controlled by a microelectromechanical system, allowing the laser beam to scan an area in a programmed fashion.

The low cost and ease of fabrication of micromirrors, along with their easy integration into electronic systems for versatile imaging operations, make them an indispensable component of the probe.

Oral cancers have traditionally been diagnosed by biopsy. Based on a doctor's visual inspection, medical practitioners remove a sample of tissue from the patient and send it off to a pathologist who will examine the tissue under a microscope to check for abnormal or malignant cells.

Results will be sent back to the doctor for the next round of diagnoses or surgery; the whole process can take up to several weeks. Not only is this process time consuming, it can be costly, invasive and painful, often leaving scars.

"Due to the lack of real-time efficient oral cancer screening tools, it is estimated that approximately $3.2 billion is spent in the United States each year on treatment of such cancers", Dr Zhang continued.

The researchers, from the University of Texas at Austin and the commercialization partner NanoLite Systems, Inc. are now planning clinical trials with a view to gaining approval from the Food and Drug Administration (FDA). They envisage that, with a few adjustments, the device could be built for a quarter of the price it costs to build the microscopes that are currently used in diagnosis, which is around $300 000.

Contact: Michael Bishop
Institute of Physics

Related biology technology :

1. Handheld plasma flashlight rids skin of notorious pathogens
2. Hothead Technologies Partners with Sivix Logistics to Add Customized Handheld Monitors and Autonomous Sensors to its Product Line
3. Novel handheld device detects anthrax with outstanding accuracy and reliability
4. Novel handheld device detects anthrax with outstanding accuracy and reliability
5. Independent U.S. Study Confirms Veritides Ceeker(TM) Handheld Device Detects Anthrax With Outstanding Accuracy and Reliability
6. HOGGAN Ergo Announces Highly Anticipated Enhancements to the ergoFET Handheld Digital Force Gauge, Greatly Impacting the Field of Ergonomic Research and Application
7. Gen-Probe Reports Financial Results for the Fourth Quarter of 2011
8. Sofie Biosciences Is Awarded a US Patent on a Family of Novel PET Probes for Use in Oncology and Immunology
9. Gen-Probe Reports Financial Results for the Second Quarter of 2011
10. Dune Medicals MarginProbe™ Demonstrates Increased Positive Margin Identification Leading to Reduction in Patients Indicated for Re-excision in Landmark Lumpectomy Surgery Trial
11. Gen-Probe to Webcast Two Upcoming Investor Presentations
Post Your Comments:
Related Image:
Handheld probe shows great promise for oral cancer detection
(Date:6/23/2016)... ... June 23, 2016 , ... ... (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. , ... tests introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the ... at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application ... team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our ...
(Date:6/23/2016)... 23, 2016 On Wednesday, June 22, ... down 0.22%; the Dow Jones Industrial Average edged 0.27% lower ... 2,085.45, down 0.17%. has initiated coverage on the following ... Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing ...
(Date:6/23/2016)... , June 23, 2016 ... research report to its pharmaceuticals section with historic ... details and much more. Complete report ... 151 pages, profiling 15 companies and supported with ... . The Global ...
Breaking Biology Technology:
(Date:6/9/2016)... 2016 Paris Police Prefecture ... security solution to ensure the safety of people and operations ... the major tournament Teleste, an international technology group ... announced today that its video security solution will be utilised ... up public safety across the country. The system roll-out is ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:6/2/2016)... June 2, 2016   The Weather Company , an ... Ads, an industry-first capability in which consumers will be able ... to ask questions via voice or text and receive relevant ... Marketers have long sought an advertising solution ... can be personal, relevant and valuable; and can scale across ...
Breaking Biology News(10 mins):