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Genzyme Reports Strong First-Quarter Growth
Date:4/23/2008

$4,450 $4,650

**GROSS MARGIN approx. 77%

**SG&A approx. 27%

**R&D approx. 17%

Net Interest / Other approx. 60

TAX RATE - GAAP approx. 30%

*TAX RATE - NON-GAAP approx. 31%

GENZ GAAP EPS approx. $2.65

AMORTIZATION approx. $0.55

FAS123 EXPENSE approx. $0.60

CONTINGENT CONVERTIBLE DEBT approx. $0.10

**GENZ NON-GAAP EPS $3.90

***WTD AVERAGE SHARES O/S approx. 274

CAPITAL EXPENDITURES approx. $500

This financial guidance, which is provided as part of a press release

dated April 21, 2008, is subject to all of the qualifications and

limitations described therein. Actual results may differ from these

forward-looking statements due to the numerous factors described in the

press release.

* Non-GAAP tax rate excludes the impact of amortization, one-time events,

FAS123R expense and EITF 04-8.

**Non-GAAP excludes the impact of amortization, one-time events, FAS123R

expense and EITF 04-8.

***WTD Average Shares Outstanding excludes the impact of EITF 04-8.


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SOURCE Genzyme Corp.
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