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Genzyme Reports Strong First-Quarter Growth
Date:4/23/2008

e Webcast will be available until midnight April 30, 2008.

Upcoming Events

Genzyme will host a conference call on July 23, 2008 at 11:00 a.m. Eastern to discuss financial results for the second quarter of 2008. To participate in the call, please dial 773-799-3828 and refer to pass code "Genzyme." A replay of this call will be available by dialing 402-998-1342. This call will also be Webcast live on the investor events section of http://www.genzyme.com. Replays of the call and the Webcast will be available until midnight on July 30, 2008.

Genzyme's press releases and other company information are available at http://www.genzyme.com and by calling Genzyme's investor information line at 1-800-905-4369 within the United States or 1-678-999-4572 outside the United States.

Media Contact: Investor Contact:

Bo Piela Patrick Flanigan

(617) 768-6579 (617) 768-6563

GENZYME CORPORATION (GENZ)

Consolidated Statements of Operations

(Unaudited, amounts in thousands, Three Months Ended

except per share amounts) March 31,

2008 2007

Total revenues $1,100,061 $883,183

Operating costs and expenses:

Cost of products and services sold (1) 272,313 202,463

Selling, general and administrative (1) 318,386 269,021

Research and development (1,2) 262,797 166,120

Amortization of intangibles 55,658 50,017

Total operating costs and expenses 909,154 687,621

Operating income (loss) 190,907 195,562

Other income (expenses):

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SOURCE Genzyme Corp.
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