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Genomatica Produces Pure BDO From Natural Sugars
Date:6/2/2009

complete package," said Matt Tirrell, dean of engineering at the University of California, Santa Barbara, and a member of Genomatica's Engineering Advisory Council. "The integration of fermentation and purification processes is vital to chemical manufacturers and an important step in Genomatica's development."

The generation of purified BDO will allow Genomatica's bio-manufacturing process to compete against petroleum-based equivalents and offer a cost advantage to producers. Many chemical producers are facing unprecedented business challenges as the global economic slowdown depresses demand, and the credit crisis hampers their ability to finance large-scale projects. Fluctuating natural gas prices and possible changes in environmental and climate regulation have added to the uncertainty for petrochemical producers.

The Genomatica Technology Advantage

Genomatica researchers were able to delicately refine the design of the process because of the integrated components that the company has developed. Genomatica's technology portfolio consists of proprietary best-in-class computational modeling, "wet lab" microbe modification and specialized chemical process engineering. The unique combination of all three elements allows for the creation of breakthrough bioprocesses to produce chemicals through faster and more integrated product development.

With proprietary computational modeling, Genomatica's researchers examine all possible biological pathways to create target chemicals from various low-cost, renewable feedstocks. In this case, they also used modeling and simulation to examine the by-products produced in earlier versions of the BDO manufacturing process, and determined exactly how to eliminate those by-products. This channels more sugar to make BDO. Armed with the "blueprint," Genomatica researchers then updated the microorganisms using a range of different state-of-the-art gen
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