Navigation Links
Genetic basis of high-risk childhood cancer points to possible new drug treatment strategy
Date:1/20/2013

MEMPHIS, Tenn., Jan. 20, 2013 /PRNewswire-USNewswire/ -- Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.

The findings also provide the first evidence of the genetic basis for this high-risk leukemia, which is known as hypodiploid acute lymphoblastic leukemia (ALL). Normal human cells have 46 chromosomes, half from each parent, but hypodiploid ALL is characterized by fewer than 44 chromosomes. Chromosomes are highly condensed pieces of DNA, the molecule that carries the inherited instructions for assembling and sustaining a person. The research appears in the January 20 advance online edition of the scientific journal Nature Genetics.

The study, the largest ever focused on hypodiploid ALL, confirmed that this tumor has distinct subtypes distinguished by the number of chromosomes lost and the submicroscopic genetic alterations they harbor. Researchers found evidence suggesting more than one-third of patients with a subtype known as low hypodiploid ALL have Li-Fraumeni syndrome. Families with Li-Fraumeni syndrome harbor inherited mutations in the TP53 tumor suppressor gene and have a high risk of a range of cancers. Hypodiploid ALL had not previously been recognized as a common manifestation of Li-Fraumeni syndrome.

Researchers reported that the major hypodiploid subtypes are both sensitive to a family of compounds that block the proliferation of cancer cells. The compounds include drugs already used to treat other cancers. The subtypes are low hypodiploid ALL, characterized by 32 to 39 chromosomes, and near haploid ALL, which has 24 to 31 chromosomes.

"This study is a good example of the important insights that can be gained by studying the largest possible number of patients in as much detail as possible. This approach
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Game changing diagnostic & prognostic prostate cancer genetic tests revealed by Jefferson
2. The Leading Edge Of Medical Innovation: New Prenatal Genetic Tests Use Moms Blood To Learn About Her Baby
3. GeneTex Launches New Antibody Against Phosphorylated Histone H3 for Epigenetics Research
4. Can a genetic variation in the vitamin D receptor protect against osteoporosis?
5. The American College of Obstetricians and Gynecologists Committee on Genetics and the Society for Maternal-Fetal Medicine Publications Committee Recommend Noninvasive Prenatal Testing for Fetal Aneuploidy
6. Arctic Reaffirms the Value of Genetic Testing for Age-Related Macular Degeneration
7. NIH Awards New England Biolabs a Phase II SBIR Grant for the Research and Development of Novel Enzymes for Epigenetic Studies
8. Response Genetics, Inc. to Offer ROS1 Testing for Lung Cancer
9. Preimplantation Genetic Diagnosis (PGD) Market is Expected to Reach USD 47.4 Million Globally in 2018: Transparency Market Research
10. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
11. Epigenetics Holds Key to Healthier Future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2015)... (PRWEB) , ... June 26, 2015 , ... ... today announced that its SimplePrep™ technologies have been integrated into a sample prep ... Space Station (ISS) as a part of the NASA’s WetLab-2 Project. , On ...
(Date:6/26/2015)... , ... June 26, 2015 , ... ReliantHeart, Inc. ... indicates that from the first implant of the HeartAssist5® LVAD (HA5) to the 68th ... HA5. , Thrombus that originates in an LVAD is referred to as de ...
(Date:6/25/2015)... , ... June 25, 2015 , ... ... keynotes speakers for its 2015 National Patient and Family Conference, Providing and Pursuing ... Chicago at the Renaissance Chicago O’Hare Suites Hotel, July 24-25, 2015. , “As ...
(Date:6/25/2015)... , June 25, 2015 ... Arzneimittel-Überprüfungs- und -Authentifizierungsdienstleistungen, führte am 24. und ... am Main das 2. Eco ... Informations-Veranstaltung zum Thema Sicherheit für Patienten in ...      (Logo: http://photos.prnewswire.com/prnh/20150610/748687) , ...
Breaking Biology Technology:Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 3HeartAssist5® Remote Monitoring has alerted no patterns of de novo thrombus in 68 consecutive implants 2HeartAssist5® Remote Monitoring has alerted no patterns of de novo thrombus in 68 consecutive implants 3Nationally Recognized Brain Tumor Experts to Speak at American Brain Tumor Association Patient and Family Conference 2Symposium zur Richtlinie über gefälschte Arzneimittel - mit Aegate in Deutschland 2Symposium zur Richtlinie über gefälschte Arzneimittel - mit Aegate in Deutschland 3
... Cerecor Inc. , a biopharmaceutical company focused on the ... activity is in the human nervous system, announced today ... overallotment of its January 2012 Series A preferred stock ... including members of Cerecor,s Board of Directors , ...
... American researchers have shown that prospective magnetic fusion power ... used for the production of weapon-usable materials than nuclear ... The researchers, from Princeton University, found that if nuclear ... there is little risk of fissile materials being produced ...
... N.Y. Jie Lian, assistant professor in the Department ... Institute, has won a prestigious Faculty Early Career Development ... Lian will use the five-year, $500,000 award to further ... in nuclear energy systems. The CAREER Award is given ...
Cached Biology Technology:Cerecor Raises $22 Million Series A Financing 2Fusion presents low proliferation risk, experts conclude 2Rensselaer professor Jie Lian receives NSF CAREER Award 2
(Date:6/25/2015)...  TAKE Solutions Ltd., a global business technology solutions ... Patent and Trademark Office (USPTO) for its "Method for ... Clinical Accelerators to reduce the time taken to standardize ... without the accelerators), thus reducing time to market. ... the heart of the patented Clinical Data Standardization Process ...
(Date:6/24/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/hhwlfj/huawei_ascend ... "Huawei Ascend Mate 7 Fingerprint Sensor - Reverse ... Huawei,s technological choice for the fingerprint sensor ... and Samsung,s one. The Ascend Mate 7 presents ... a main actor in capacitive sensing human interface ...
(Date:6/23/2015)... N.C. , June 23, 2015   ... today announced the results of a recent study ... accuracy on the wrist during activity. In a ... technology was compared along with the Apple Watch ... accurately measuring heart rate during activity. The study ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3
... December 7, 2012 More than 100 academic ... major world-wide initiative: Mathematics of Planet Earth (MPE) ... made by mathematics in tackling global problems, including ... climate change; sustainability; and pandemics. MPE2013 partners will ...
... plant growth patterns are influenced by a variety of ... roots exhibit characteristic behaviours called ,waving, and ,skewing, which ... plants grown on the International Space Station (ISS) ... published in BioMed Central,s open access journal BMC ...
... a biological adaptation that enables them to thrive in the ... on the trait appears to be linked to different genes ... University scientist and colleagues shows. The adaptation is the ... of hemoglobin, the oxygen-carrying protein in red blood cells. Members ...
Cached Biology News:Mathematicians tackle global issues 2Mathematicians tackle global issues 3What happens to plant growth when you remove gravity? 2Different genes behind same adaptation to thin air 2
... The Neural Stem Cell Expansion Kit - Neurosphere ... neural stem cell expansion as neurospheres in ... specially formulated N-2 Plus Media Supplement, which has ... K.K. et al . (1996) Genes & ...
DNase I (Deoxyribonuclease I) digests single- and double-stranded DNA to oligodeoxyribonucleotides. Ribonuclease activity has been reduced to non-detectable levels....
... E. coli strain containing an overproducing clone ... Reverse Transcriptase catalyzes the polymerization of DNA ... Full-length copies of large mRNAs, >10 kb, ... a much lower RNase H activity than ...
... RQ1 RNase-Free DNase is a preparation ... or double-stranded DNA to produce 3-hydroxyl ... use in applications where maintaining the ... DNase is qualified for use with ...
Biology Products: