IRVINE, Calif., Nov. 29, 2011 /PRNewswire/ -- GeneTex, a leading manufacturer of antibodies and antibody-related reagents, is pleased to announce that they will be launching a new line of antibodies against Hice1 and Hec1. Both of these targets are key players in spindle assembly.
Hice1 is a novel microtubule-associated protein that is required for the maintenance of spindle integrity and chromosomal stability, and the phosphorylation of Hec1 by Nek2 kinase has been shown to modulate chromosome alignment and signaling of the spindle assembly checkpoint. The interaction between Hec1 and Hice also contributes to mitotic centrosomal microtubule growth for proper spindle assembly.
GeneTex's new product line will include a phospo Ser 55 Hec1 antibody, a non-phospho Ser 55 Hec1 antibody, a phospo Ser 76/77 Hec1 antibody, a non-phospho Ser 76/77 Hec1 antibody, a phospo Ser 165 Hec1 antibody, a non-phospho Ser 165 Hec1 antibody, a phospho Ser 19/20 Hice1 antibody, a non-phospho Ser 19/20 Hice1 antibody, as well as corresponding blocking peptides. A complete listing of Hec1 and Hice1 antibodies is available at http://www.genetex.com/Hec1_Hice1.
"I am thrilled to be working with GeneTex to bring these antibodies to a wider group of researchers," said Dr. Guikai Wu, a researcher from the University of California, Irvine who developed these antibodies and has recently published his results in Molecular and Cellular Biology ("Hice1, a Novel Microtubule-Associated Protein Required for Maintenance of Spindle Integrity and Chromosomal Stability in Human Cells") and Molecular Biology of the Cell ("Hec1 Contributes to Mitotic Centrosomal Microtubule Growth for Proper Spindle Assembly through Interaction with Hice1"). "These are excellent antibodies that have worked in every application that I have tried."
The study of spindle assembly has widespread applications, as this process is critical for efficient mitotic progression and accurate chromosome segregation. Errors in this process often lead to structural and functional aberrations that result in the promotion of segregation errors and aneuploidy, a hallmark of most cancers.
GeneTex will be launching one of the largest collections of Hec1 and Hice1 antibodies that have been validated for western blotting, immunofluorescence (ICC/IF), immunohistochemistry (IHC) and other applications. Almost all of the antibodies in the line are antigen-affinity purified, which results in higher quality antibodies for research. GeneTex will also be offering smaller-sized vials of their zebrafish antibodies, allowing researchers the flexibility to try new antibodies at a much lower cost.
For additional information on GeneTex's new line of Hec1 and Hice1 antibodies, call toll-free 877-GENETEX (436-3839) or visit http://www.genetex.com/Hec1_Hice1.
GeneTex is an antibody company that was founded by scientists in 1997. They strive to produce the highest quality antibodies and reagents. Their primary antibodies and secondary antibodies are created through a process involving extensive research, development and validation. GeneTex has over 45,000 primary antibodies in its catalog that are all backed by a 100% Satisfaction Guarantee.
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