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GeneGo Collaborates With The Netherlands Toxicogenomics Center on $100 Million Grant

ST. JOSEPH, Mich., Feb. 13 /PRNewswire/ -- GeneGo, Inc., the leading systems biology tools company, announced today that they will be collaborating with The Netherlands Toxicogenomics Center (NTC). This 5 year, 25 Million Euro, multi-party program will use toxicogenomics to develop highly predictive 'omics-based screens, to be used for the in depth evaluation of chemical safety for human health, replacing, reducing or refining animal experiments, and improving the scientific basis of chemical risk assessment.

The NTC will use GeneGo's MetaCore and MetaDrug systems biology data analysis platform to coordinate, visualize and interpret chemical, metabolomic, proteomic and gene expression data generated by the project members, and to identify the key biological functions and pathways contributing to the adverse effects of xenobiotic exposure. GeneGo will further contribute by working within the bioinformatics workgroup of the NTC to build predictive models, using GeneGo's "Functional Descriptor" technology, for the earlier identification of adverse effects in animals from short-term in vivo experiments, or from in vitro experiments using cells in place of animals.

Professor Jos Kleinjans, Director of the NTC said "having GeneGo as a partner in the project, and having access to their leading systems biology data visualization and analysis tools and expertise, will help us to derive the best value from the data we are generating and make progress in the application of an integrated systems toxicology approach to risk assessment."

Dr. Richard Brennan, Director of Toxicology at GeneGo, said, "We are delighted to be a part of this exciting and ambitious project. The tools we have developed at GeneGo are an excellent solution for analyzing the multiple data types that will be generated by the NTC members and for understanding the biological basis of chemically-induced toxicity. The project will help us to further validate and develop our capabilities in predictive systems toxicology."

About GeneGo

GeneGo develops systems biology technology for life science research. The original computational MetaDiscovery(TM) platform allows an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics, metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. GeneGo's flagship product, MetaCore 4.6(TM), assists pharmaceutical scientists in the areas of target selection and validation, identification of biomarkers for disease states and toxicology. The second product, MetaDrug 4.6(TM) is designed for prediction of human metabolism, toxicity and biological effects for novel small molecules compounds. MetaBase(TM) represents the knowledge base for MetaCore. For more information, please visit the company's web site at

MetaCore(TM), MetaBase(TM) MetaDrug(TM) , MetaLink(TM), MetaDiscovery(TM), MetaTox(TM) , MetaMiner(TM) and 1-2-3 Workflow(TM) are trademarks of GeneGo, Inc.

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