Navigation Links
Football-shaped particles bolster the body's defense against cancer
Date:10/19/2013

Researchers at Johns Hopkins have succeeded in making flattened, football-shaped artificial particles that impersonate immune cells. These football-shaped particles seem to be better than the typical basketball-shaped particles at teaching immune cells to recognize and destroy cancer cells in mice.

"The shape of the particles really seems to matter because the stretched, ellipsoidal particles we made performed much better than spherical ones in activating the immune system and reducing the animals' tumors," according to Jordan Green, Ph.D., assistant professor of biomedical engineering at the Johns Hopkins University School of Medicine and a collaborator on this work. A summary of the team's results was published online in the journal Biomaterials on Oct. 5.

According to Green, one of the greatest challenges in the field of cancer medicine is tracking down and killing tumor cells once they have metastasized and escaped from a tumor mass. One strategy has been to create tiny artificial capsules that stealthily carry toxic drugs throughout the body so that they can reach the escaped tumor cells. "Unfortunately, traditional chemotherapy drugs do not know healthy cells from tumor cells, but immune system cells recognize this difference. We wanted to enhance the natural ability of T-cells to find and attack tumor cells," says Jonathan Schneck, M.D., Ph.D., professor of pathology, medicine and oncology.

In their experiments, Schneck and Green's interdisciplinary team exploited the well-known immune system interaction between antigen-presenting cells (APC) and T-cells. APCs "swallow" invaders and then display on their surfaces chewed-up protein pieces from the invaders along with molecular "danger signals." When circulating T-cells interact with APCs, they learn that those proteins come from an enemy, so that if the T-cells see those proteins again, they divide rapidly to create an army that attacks and kills the invaders.


'/>"/>
Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Microparticles and Applications in Assays and Endpoints, New Life Science Webinar Hosted by Xtalks
2. Researchers use nanoparticles to deliver vaccines to lungs
3. UCLA researchers smartphone microscope can detect a single virus, nanoparticles
4. New nanoparticles make solar cells cheaper to manufacture
5. Gold nanoparticles improve photodetector performance
6. Light particles illuminate the vacuum
7. Penn researchers develop protein passport that help nanoparticles get past immune system
8. Widely used nanoparticles enter soybean plants from farm soil
9. Nanoparticles digging the worlds smallest tunnels
10. New information on binding gold particles over metal oxide surfaces
11. Lung mucus gel scaffold prevents nanoparticles from getting through
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Football-shaped particles bolster the body's defense against cancer
(Date:7/30/2015)... AACC welcomed thousands of medical professionals ... Meeting & Clinical Lab Expo in ... showcased revolutionary advancements in clinical testing technology and ... to diagnose patients quickly and accurately and make ... As of Wednesday, July 29, more than ...
(Date:7/30/2015)... Washington , July 30, 2015 ... Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, Trial ... Discovery & Development, Preclinical, Clinical Trial), by End Users ... Biosimulation Market is expected to reach USD 2,107.99 million ... a CAGR of 15.29%. Browse more ...
(Date:7/30/2015)... 60,000 customers across the globe, ISN improves the efficiency and effectiveness of contractor management ... safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... , ... July 30, 2015 , ... As part of its 2015 growth plan and ... and technical service business units, Whitehouse Laboratories is pleased to announce that it ... to the Container Center of Excellence and will be strictly dedicated to basic USP 51, ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... Cell Therapeutics, Inc. ("CTI") (Nasdaq and MTA: CTIC) today ... offer (the "Exchange Offer") to exchange shares of its common ... aggregate of $89.2 million principal amount for the following outstanding ... , 4% Convertible Senior ...
... , - German Chemical Parks Record ... The number of employees in German chemical parks has ... this same period, the number of,companies doing business at these ... by Dr. Klaus-Dieter Juszak, Chairman of the,German Sector Group of ...
... (NYSE: LLY ) will unveil data from more ... American Society of Clinical Oncology (ASCO) in Orlando, Fla. from ... the presentations continuing to support Lilly,s leadership in thoracic cancer ... on ALIMTA(R) (pemetrexed for injection), as well as GEMZAR(R) (gemcitabine ...
Cached Biology Technology:Cell Therapeutics to Exchange up to $89.2 million of Its Outstanding Convertible Notes in a 'Modified Dutch Auction' Tender Offer 2Cell Therapeutics to Exchange up to $89.2 million of Its Outstanding Convertible Notes in a 'Modified Dutch Auction' Tender Offer 3Cell Therapeutics to Exchange up to $89.2 million of Its Outstanding Convertible Notes in a 'Modified Dutch Auction' Tender Offer 4Cell Therapeutics to Exchange up to $89.2 million of Its Outstanding Convertible Notes in a 'Modified Dutch Auction' Tender Offer 5Cell Therapeutics to Exchange up to $89.2 million of Its Outstanding Convertible Notes in a 'Modified Dutch Auction' Tender Offer 610,000 New Jobs, Investments Increased 210,000 New Jobs, Investments Increased 3Lilly Set to Unveil More Than 50 Studies at ASCO 2009 2Lilly Set to Unveil More Than 50 Studies at ASCO 2009 3Lilly Set to Unveil More Than 50 Studies at ASCO 2009 4Lilly Set to Unveil More Than 50 Studies at ASCO 2009 5Lilly Set to Unveil More Than 50 Studies at ASCO 2009 6
(Date:7/31/2015)... , 31 de julio de 2015 La ... ) se celebrará por medio de BGI del 22 al 25 ... . Este año, la conferencia celebra su ... se ha convertido en una de las reuniones anuales más ... una de las reuniones más dinámicas, entusiastas y mejores a ...
(Date:7/31/2015)... , July 31, 2015 The 10 th ... held by BGI from October 22-25, 2015, in Shenzhen ... The conference is celebrating its 10 th anniversary this year. ... the world,s most influential annual meetings in the ,omics, fields, ... scientific gatherings. ICG-10 focuses on recent breakthroughs ...
(Date:7/27/2015)... 27, 2015   Zynx Health ™, the ... improvement solutions, today announced that its ZynxCarebook ... on Android smartphones and tablets. With this expansion, ... can use ZynxCarebook to securely exchange messages and ... care transitions to other care settings, and improve ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... genetic material in our cells are iconically depicted as ... cell is about to divide and the entire contents of ... to get a good picture of the way that our ... is neatly bundled into the nucleus while enabling day-to-day (non-dividing) ...
... (Nov. 25 2013) After Schwann cells (SCs), the principal ... (OECs), cells that ensheath the non-myelinated peripheral neurons in the ... researchers in Beijing, China put the rats on a 30 ... determine if the effects of the workouts would benefit aspects ...
... as they are "smart": too elementary to be able to ... by inserting pieces of their own DNA so that it ... first have to inject their own genetic material into the ... Micheletti from SISSA (the International School for Advanced Studies in ...
Cached Biology News:Chromosomes show off their shapes 2Co-transplanted cells and treadmill training aids rats with spinal cord injury 2Tidy knots are faster 2
... TSQ Quantum Ultra defines a new standard ... analysis. It features the revolutionary Ion ... titanium skimmer with superior skimming and larger ... Its redesigned ion transfer tube lens with ...
... double stranded RNA (dsRNA) has been shown ... group of organisms as well as insect ... the inhibition of protein expression by utilizing ... RNA (mRNA). Attempts to induce RNA interference ...
... tetramethylrhodamine-conjugated jetSI-ENDO (excitation at 555 ... the powerful siRNA transfection reagent. ... determine the transfection efficiency or ... trafficking of siRNAs. More than ...
... Bruker Daltonics and Bruker BioSpins ... for metabolism studies, and analysis of ... ESI-TOF system, an optional Avance NMR ... acquisition, evaluation and statistical analysis for ...
Biology Products: