Navigation Links
Football-shaped particles bolster the body's defense against cancer
Date:10/19/2013

Researchers at Johns Hopkins have succeeded in making flattened, football-shaped artificial particles that impersonate immune cells. These football-shaped particles seem to be better than the typical basketball-shaped particles at teaching immune cells to recognize and destroy cancer cells in mice.

"The shape of the particles really seems to matter because the stretched, ellipsoidal particles we made performed much better than spherical ones in activating the immune system and reducing the animals' tumors," according to Jordan Green, Ph.D., assistant professor of biomedical engineering at the Johns Hopkins University School of Medicine and a collaborator on this work. A summary of the team's results was published online in the journal Biomaterials on Oct. 5.

According to Green, one of the greatest challenges in the field of cancer medicine is tracking down and killing tumor cells once they have metastasized and escaped from a tumor mass. One strategy has been to create tiny artificial capsules that stealthily carry toxic drugs throughout the body so that they can reach the escaped tumor cells. "Unfortunately, traditional chemotherapy drugs do not know healthy cells from tumor cells, but immune system cells recognize this difference. We wanted to enhance the natural ability of T-cells to find and attack tumor cells," says Jonathan Schneck, M.D., Ph.D., professor of pathology, medicine and oncology.

In their experiments, Schneck and Green's interdisciplinary team exploited the well-known immune system interaction between antigen-presenting cells (APC) and T-cells. APCs "swallow" invaders and then display on their surfaces chewed-up protein pieces from the invaders along with molecular "danger signals." When circulating T-cells interact with APCs, they learn that those proteins come from an enemy, so that if the T-cells see those proteins again, they divide rapidly to create an army that attacks and kills the invaders.


'/>"/>
Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Microparticles and Applications in Assays and Endpoints, New Life Science Webinar Hosted by Xtalks
2. Researchers use nanoparticles to deliver vaccines to lungs
3. UCLA researchers smartphone microscope can detect a single virus, nanoparticles
4. New nanoparticles make solar cells cheaper to manufacture
5. Gold nanoparticles improve photodetector performance
6. Light particles illuminate the vacuum
7. Penn researchers develop protein passport that help nanoparticles get past immune system
8. Widely used nanoparticles enter soybean plants from farm soil
9. Nanoparticles digging the worlds smallest tunnels
10. New information on binding gold particles over metal oxide surfaces
11. Lung mucus gel scaffold prevents nanoparticles from getting through
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Football-shaped particles bolster the body's defense against cancer
(Date:8/26/2014)... 26, 2014 Genedata, a leading ... and life science research, today announced the ... be held in Asia, Europe, and North America ... companies and leading research organizations will gather for ... case studies, and upcoming challenges in all areas ...
(Date:8/26/2014)... CITY, Calif. , Aug. 26, 2014 /PRNewswire/ ... development and commercialization of oncology diagnostic products, has ... as a 2015 Technology Pioneer . As ... is one of 24 companies across a wide ... prestigious accolade. Guardant360 ® , ...
(Date:8/26/2014)... Cary, NC (PRWEB) August 26, 2014 ... built-in GMP processes, implemented a new pricing structure with ... better comply with cGMP and 21 CFR Part 11 ... Good Manufacturing Practices any way we can” said Rick ... the number of available users allowed customers to have ...
(Date:8/26/2014)... 26, 2014 Historically, drug development ... list continues to grow – high attrition rate, ... and development, high regulatory hurdles and increasing ... become clear that the traditional business model of ... are now seeking to find better ways to ...
Breaking Biology Technology:Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 3Guardant Health Named a 2015 Technology Pioneer by World Economic Forum 2Transitioning from Bench into Clinical Phase, new webinar hosted by Xtalks 2
... Md., Sept. 4 Human Genome,Sciences, Inc. (Nasdaq: ... at the,BioCentury - Thomson Financial 14th Anniversary NewsMakers ... may be accessed at, http://www.hgsi.com . ... of Human Genome Sciences, senior management team will ...
... Sept. 4 Takeda San Diego announced today,that ... chief scientific,officer (CSO). In this position, he is ... Diego, Takeda Pharmaceutical Company,Limited,s U.S.-based drug discovery company. ... of Takeda San Diego for several,years and brings ...
... (Nasdaq: ALTH ), a biopharmaceutical company focused ... for,the treatment of cancer, today announced that Paul ... overview at the Bear Stearns 20th Annual,Healthcare Conference ... take place at 9:00 a.m. (Eastern) on,Monday, September ...
Cached Biology Technology:Dr. Keith Wilson Named President and Chief Scientific Officer of Takeda San Diego 2Allos Therapeutics to Present at the Bear Stearns 20th Annual Healthcare Conference 2
(Date:8/25/2014)... Scientists have known that toxic effects of substances ... both natural and human-made materials, can pass from ... shows that females with ancestral exposure to EDC ... According to a new study by researchers from ... State University, male and female rats are affected ...
(Date:8/25/2014)... 133 active fires in the North Slave Region of the ... 24 hours. Fire danger is moderate to high. Smoke ... Lake Complex of fires are in an area approximately 80 ... north of Fort Providence. Four crews will be working ... week. Mop-up continues many areas of complex,s fire perimeter. The ...
(Date:8/25/2014)... a lightning strike on August 12, 2014. Currently the ... There are close to 2,000 personnel working on this ... and a number of large ones. Most of the ... 100 acres. An inversion layer settled over the fire ... keeping fire activity moderate. As the inversion lifted in the ...
Breaking Biology News(10 mins):Exposure to toxins makes great granddaughters more susceptible to stress 2Happy Camper and July Fire Complexes in California 2
... complaint against British drug maker GlaxoSmithKline (GSK) over its ... proceed following an order late last week by South ... go forward. GSK has sought outright dismissal of the ... week giving the complainants, AIDS Healthcare Foundation (AHF) and ...
... discovered a specialized night-vision brain area in night-migratory songbirds. ... navigate by the stars, and to visually detect the ... modulated by the field. , The researchers published their ... of the Proceedings of the National Academy of Sciences. ...
... genome sequence annotation, high-throughput cloning methodologies, and automation, ... lead by Leonardo Brizuela (Harvard Medical School lecturer ... databases to collect the sequence information of all ... gene repository for this gene class. Their work ...
Cached Biology News:South African Tribunal Asks For Damages Estimates in GSK AIDS Drug Case 2Migratory songbirds have a specialized night-vision brain area 2
...
...
... Formulation: 50mM Tris-HCl, pH 7.5, ... PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol ... (Protein Phosphatase 2A1) partially purified ... precipitation, QSepharose,amino-hexyl agarose, Superdex 200, ...
Borosilicate Glass. Certified for use with the Beacon 2000 Systems, 1,000 tubes/case...
Biology Products: