Navigation Links
'Flipping the switch' reveals new compounds with antibiotic potential
Date:10/31/2013

CORVALLIS, Ore. Researchers at Oregon State University have discovered that one gene in a common fungus acts as a master regulator, and deleting it has opened access to a wealth of new compounds that have never before been studied with the potential to identify new antibiotics.

The finding was announced today in the journal PLOS Genetics, in research supported by the National Institutes of Health and the American Cancer Society.

Scientists succeeded in flipping a genetic switch that had silenced more than 2,000 genes in this fungus, the cereal pathogen Fusarium graminearum. Until now this had kept it from producing novel compounds that may have useful properties, particularly for use in medicine but also perhaps in agriculture, industry, or biofuel production.

"About a third of the genome of many fungi has always been silent in the laboratory," said Michael Freitag, an associate professor of biochemistry and biophysics in the OSU College of Science. "Many fungi have antibacterial properties. It was no accident that penicillin was discovered from a fungus, and the genes for these compounds are usually in the silent regions of genomes.

"What we haven't been able to do is turn on more of the genome of these fungi, see the full range of compounds that could be produced by expression of their genes," he said. "Our finding should open the door to the study of dozens of new compounds, and we'll probably see some biochemistry we've never seen before."

In the past, the search for new antibiotics was usually done by changing the environment in which a fungus or other life form grew, and see if those changes generated the formation of a compound with antibiotic properties.

"The problem is, with the approaches of the past we've already found most of the low-hanging fruit, and that's why we've had to search in places like deep sea vents or corals to find anything new," Freitag said. "With traditional appr
'/>"/>

Contact: Michael Freitag
freitagm@science.oregonstate.edu
541-737-4845
Oregon State University
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. An optical switch based on a single nano-diamond
2. Netswitch Technology Management Ranks in Top 100 Cloud and Managed Service Providers
3. Save Space with Scienceware® Switch-Grid™ Test Tube Racks by Bel-Art Products
4. Cornell bioengineers discover the natural switch that controls spread of breast cancer cells
5. Penn researchers make first all-optical nanowire switch
6. Millions of DNA switches that power human genomes operating system are discovered
7. Metamolecules that switch handedness at light-speed
8. Switchable nano magnets
9. Reversible doping: Hydrogen flips switch on vanadium oxide
10. The smallest conceivable switch
11. Find The Black Box Reveals how Troubled Doctors Have Found a Haven in Texas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Flipping the switch' reveals new compounds with antibiotic potential
(Date:12/19/2014)... Reports from CDC show ... from one or more chronic health conditions - including ... address some of these diseases, but may not eliminate ... face. While implanted nerve stimulation devices today offer relief, ... which can induce side effects. , To eliminate ...
(Date:12/19/2014)... CA (PRWEB) December 18, 2014 With ... limited time special on Sartorius Biohit products . ... on mLINE pipettes, Picus Electronic Pipette Trade-in Program, and ... Health and Safety officers around the world. They are ... pipetting. Other features include:, ,     Full volume ...
(Date:12/19/2014)... Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage ... pain, announced the results of its annual general meeting ... transformational year in Relmada,s history and it set the ... Sergio Traversa , chief executive officer of Relmada. ... financial, human resource and clinical development objectives that position ...
(Date:12/17/2014)... 2014 Achim Noack has been named ... Group. In this position, Noack will assist Jerry Stoller, ... develop marketing strategy and supervise global marketing management and ... has tremendous knowledge and experience in the crop protection ... experience and innovative thinking will be a great asset ...
Breaking Biology Technology:Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... - Saying his higher education initiatives would increase the ... Jim Doyle has urged lawmakers to advance his ... has proposed the direct spending of $225 million to ... capabilities, and recruit more faculty members. The Legislature ...
... that patents and publications used to uphold a challenge to ... proliferation of human embryonic stem cells, the Wisconsin Alumni ... an initial determination by the U.S. Patent and Trademark ... Gulbrandsen, managing director of WARF, were supported by Dr. ...
... Madison, Wis. - Peter Logothetis pondered the ... concluded that it's part of a natural - and ... meet corporate objectives, to building strong working relationships with ... the business as well as information technology, the position ...
Cached Biology Technology:WARF questions relevancy of documents used to uphold patent challenge 2WARF questions relevancy of documents used to uphold patent challenge 3CIO Leadership Series: Logothetis likes CIO's evolving role 2CIO Leadership Series: Logothetis likes CIO's evolving role 3CIO Leadership Series: Logothetis likes CIO's evolving role 4CIO Leadership Series: Logothetis likes CIO's evolving role 5
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ... robust – with the clinical data to back it ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition ... Region 2015-2019"  report to their offering. ... is advances in technology. With continuous advances in ... to the latest standard that meets the needs ...
(Date:12/10/2014)... 8, 2014 You,ve been here before: you desperately ... remember your password, site key or the answer to your ... grade teacher? Today, Hoyos Labs , ... that will finally put an end to the frustration that ... . 1U leverages a user,s smartphone to acquire his ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... 21 September, 2006 - Elsevier is delighted to ... the journal Vaccine: HPV Vaccines and Screening in ... provides a comprehensive and invaluable update for paediatricians, ... major donor institutions worldwide. , With the arrival ...
... is time to protect patients from “vile and cynical exploitation?by ... week’s BMJ. , It is estimated that up to 80% ... follow a dietary programme to help treat their cancer, writes ... , Yet the rationale for the use of many of ...
... used for intestinal research, the colonsope, causes patients great ... developed, inspired by the way in which snails move. ... degree from TU Delft based on this research subject. ... to navigate through with a medical device. Yet, many ...
Cached Biology News:Protect patients from exploitation by alternative medicines industry 2Like a snail through the intestinal canal 2
2,4,6, Trinitrophenyl hapten is conjugated to lipopolysaccharide (LPS)....
... creates isogenic cell lines all transfected ... protein of interest. This homogeneous expression ... link below). In this experiment the ... was subcloned into pcDNA5/FRT and transfected ...
Fast, sensitive quantitation of total MEK 1/2 concentration....
... High Sensitivity Laboratory Osmometer for 50 L samples. Operating head automatically rises at the end of determination; ... ... ... ...
Biology Products: