Navigation Links
'Flipping the switch' reveals new compounds with antibiotic potential
Date:10/31/2013

CORVALLIS, Ore. Researchers at Oregon State University have discovered that one gene in a common fungus acts as a master regulator, and deleting it has opened access to a wealth of new compounds that have never before been studied with the potential to identify new antibiotics.

The finding was announced today in the journal PLOS Genetics, in research supported by the National Institutes of Health and the American Cancer Society.

Scientists succeeded in flipping a genetic switch that had silenced more than 2,000 genes in this fungus, the cereal pathogen Fusarium graminearum. Until now this had kept it from producing novel compounds that may have useful properties, particularly for use in medicine but also perhaps in agriculture, industry, or biofuel production.

"About a third of the genome of many fungi has always been silent in the laboratory," said Michael Freitag, an associate professor of biochemistry and biophysics in the OSU College of Science. "Many fungi have antibacterial properties. It was no accident that penicillin was discovered from a fungus, and the genes for these compounds are usually in the silent regions of genomes.

"What we haven't been able to do is turn on more of the genome of these fungi, see the full range of compounds that could be produced by expression of their genes," he said. "Our finding should open the door to the study of dozens of new compounds, and we'll probably see some biochemistry we've never seen before."

In the past, the search for new antibiotics was usually done by changing the environment in which a fungus or other life form grew, and see if those changes generated the formation of a compound with antibiotic properties.

"The problem is, with the approaches of the past we've already found most of the low-hanging fruit, and that's why we've had to search in places like deep sea vents or corals to find anything new," Freitag said. "With traditional appr
'/>"/>

Contact: Michael Freitag
freitagm@science.oregonstate.edu
541-737-4845
Oregon State University
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. An optical switch based on a single nano-diamond
2. Netswitch Technology Management Ranks in Top 100 Cloud and Managed Service Providers
3. Save Space with Scienceware® Switch-Grid™ Test Tube Racks by Bel-Art Products
4. Cornell bioengineers discover the natural switch that controls spread of breast cancer cells
5. Penn researchers make first all-optical nanowire switch
6. Millions of DNA switches that power human genomes operating system are discovered
7. Metamolecules that switch handedness at light-speed
8. Switchable nano magnets
9. Reversible doping: Hydrogen flips switch on vanadium oxide
10. The smallest conceivable switch
11. Find The Black Box Reveals how Troubled Doctors Have Found a Haven in Texas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Flipping the switch' reveals new compounds with antibiotic potential
(Date:10/30/2014)... MA (PRWEB) October 30, 2014 ... and collaboration provider, offers Office 365 end users ... into a complete phone system by adding voice ... 365 (O365) includes Lync Online, a communication tool ... Lync calls. With hosted voice, O365 becomes a ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 James Sherley says ... in adult tissue stem cell technology since his days as ... in Philadelphia in the late 1990’s. Sherley founded the ... The company holds all the intellectual property developed in Sherley’s ... at the Massachusetts Institute of Technology (MIT), and more recently ...
(Date:10/30/2014)... NY (PRWEB) October 30, 2014 Whitehouse ... for its ICH Stability Testing and Package Test Capacity. ... investment centers on a dramatic increase in environmental chamber ... of stability, storage and aging samples to be securely ... of this major capital expenditure has already taken place ...
(Date:10/30/2014)... October 30, 2014 Grace Century portfolio project, ... A. Manganello, Chairman of the Board, to the National ... The appointment was made by the Ministry of Health on ... 2014. , More than a year after Bahamian ... , Prime Minister Perry Christie said the government has completed ...
Breaking Biology Technology:SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
... ... ... ... ...
... ... ... ... ...
... ... ... ... ...
Cached Biology Technology:VIVUS to Present at Two Upcoming Investor Conferences 2VIVUS to Present at Two Upcoming Investor Conferences 3Foamix Ltd. and Therapeutics Inc. Enter Into Joint Venture to Develop New Prescription Foams for Inflammatory Skin Diseases - Will Target Over 20 Million Psoriasis and Atopic Dermatitis Patients 2Foamix Ltd. and Therapeutics Inc. Enter Into Joint Venture to Develop New Prescription Foams for Inflammatory Skin Diseases - Will Target Over 20 Million Psoriasis and Atopic Dermatitis Patients 3Foamix Ltd. and Therapeutics Inc. Enter Into Joint Venture to Develop New Prescription Foams for Inflammatory Skin Diseases - Will Target Over 20 Million Psoriasis and Atopic Dermatitis Patients 4Foamix Ltd. and Therapeutics Inc. Enter Into Joint Venture to Develop New Prescription Foams for Inflammatory Skin Diseases - Will Target Over 20 Million Psoriasis and Atopic Dermatitis Patients 5Foamix Ltd. and Therapeutics Inc. Enter Into Joint Venture to Develop New Prescription Foams for Inflammatory Skin Diseases - Will Target Over 20 Million Psoriasis and Atopic Dermatitis Patients 6Foamix Ltd. and Therapeutics Inc. Enter Into Joint Venture to Develop New Prescription Foams for Inflammatory Skin Diseases - Will Target Over 20 Million Psoriasis and Atopic Dermatitis Patients 7Repligen Announces Acquisition of Chromatography Technology Platform 2Repligen Announces Acquisition of Chromatography Technology Platform 3Repligen Announces Acquisition of Chromatography Technology Platform 4
(Date:10/29/2014)... New research presented at the Society for ... TX showed for the first time that it ... using a readily available nutritional supplement, AHCC. ... Judith A. Smith, Pharm.D., associate professor in the ... The University of Texas Health Science Center at ...
(Date:10/29/2014)... their food, but they also need protection from its harmful ... of molecules in plants that shields them from sun damage. ... American Chemical Society , one team reports on the mechanics ... and colleagues at Purdue University note that the harsh ultraviolet ... to plant DNA and, as a result, hinder plant growth. ...
(Date:10/29/2014)... City on September 19, 2014, leading geneticist and humanitarian ... Genome Sciences and Medicine at the University of Washington ... Tel Aviv University, was awarded the 2014 Lasker-Koshland Special ... her honorary degree from TAU, Prof. King was the ... and for the past 18 years she has been ...
Breaking Biology News(10 mins):HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2
... Patients who are fed more calories while in intensive ... less of their daily-prescribed calories, according to a recent ... database in the world. "Our finding is significant ... in the area of critical care nutrition that have ...
... down weight gain and serve as another tool in the ... Obese mice that were fed a compound found in green ... slowly than a control group of mice that did not ... of food science in agricultural sciences. "In this experiment, ...
... new report by researchers from the Smithsonian Tropical ... identifies gaps in forest monitoring and ways to ... of greenhouse gas emission reductions from activities aimed ... proposal to Reduce Emissions from Deforestation and Forest ...
Cached Biology News:Green tea helps mice keep off extra pounds 2Panama REDD: Getting what you pay for 2
Polyclonal Antibody to CRTR-1...
Recognizes NSCL1. The molecular weight of the protein is 14,616 Daltons....
Mouse monoclonal [3G131] to Desmoglein 1 ( Abpromise for all tested applications). entrezGeneID: 1828 SwissProtID: Q02413...
Mouse monoclonal [2D7/1] to E.coli LPS ( Abpromise for all tested applications). Antigen: Tissue / cell preparation: Escherichia coli J5 cells....
Biology Products: