Navigation Links
'Flipping the switch' reveals new compounds with antibiotic potential
Date:10/31/2013

CORVALLIS, Ore. Researchers at Oregon State University have discovered that one gene in a common fungus acts as a master regulator, and deleting it has opened access to a wealth of new compounds that have never before been studied with the potential to identify new antibiotics.

The finding was announced today in the journal PLOS Genetics, in research supported by the National Institutes of Health and the American Cancer Society.

Scientists succeeded in flipping a genetic switch that had silenced more than 2,000 genes in this fungus, the cereal pathogen Fusarium graminearum. Until now this had kept it from producing novel compounds that may have useful properties, particularly for use in medicine but also perhaps in agriculture, industry, or biofuel production.

"About a third of the genome of many fungi has always been silent in the laboratory," said Michael Freitag, an associate professor of biochemistry and biophysics in the OSU College of Science. "Many fungi have antibacterial properties. It was no accident that penicillin was discovered from a fungus, and the genes for these compounds are usually in the silent regions of genomes.

"What we haven't been able to do is turn on more of the genome of these fungi, see the full range of compounds that could be produced by expression of their genes," he said. "Our finding should open the door to the study of dozens of new compounds, and we'll probably see some biochemistry we've never seen before."

In the past, the search for new antibiotics was usually done by changing the environment in which a fungus or other life form grew, and see if those changes generated the formation of a compound with antibiotic properties.

"The problem is, with the approaches of the past we've already found most of the low-hanging fruit, and that's why we've had to search in places like deep sea vents or corals to find anything new," Freitag said. "With traditional appr
'/>"/>

Contact: Michael Freitag
freitagm@science.oregonstate.edu
541-737-4845
Oregon State University
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. An optical switch based on a single nano-diamond
2. Netswitch Technology Management Ranks in Top 100 Cloud and Managed Service Providers
3. Save Space with Scienceware® Switch-Gridâ„¢ Test Tube Racks by Bel-Art Products
4. Cornell bioengineers discover the natural switch that controls spread of breast cancer cells
5. Penn researchers make first all-optical nanowire switch
6. Millions of DNA switches that power human genomes operating system are discovered
7. Metamolecules that switch handedness at light-speed
8. Switchable nano magnets
9. Reversible doping: Hydrogen flips switch on vanadium oxide
10. The smallest conceivable switch
11. Find The Black Box Reveals how Troubled Doctors Have Found a Haven in Texas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Flipping the switch' reveals new compounds with antibiotic potential
(Date:5/21/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: RP) ... focused on the development of autologous cell therapies, ... International Society for Cellular Therapy (ISCT) on RepliCel,s ... in a Phase 1/2 clinical trial.  The presentation, ... 5:30 PM to 7:00 PM local time, will ...
(Date:5/20/2015)... Calif. , May 20, 2015 ... today presented preliminary data demonstrating the ability of ... pulmonary fibrosis (IPF) from other interstitial lung diseases ... suggest the classifier,s potential to help thousands of ... resolve ambiguity in IPF diagnosis – a frequent ...
(Date:5/20/2015)... and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ) has announced ... Outlook 2020 " report to their offering. ... medicine is expected to have huge marketing potential. Presently, ... the growth of deregulated organs. Several therapeutic molecules are ... form new tissue or sometimes organ transplant is required. ...
(Date:5/20/2015)... , May 20, 2015  Health eCareers, ... short-staffed healthcare organizations with job seekers looking for ... , a new mobile and online tool dedicated ... healthcare industry. SHIFT enables employers to ... tenens, travel nursing, per diem and other temporary ...
Breaking Biology Technology:RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
... New research at Rice University shows that tiny worlds may ... Pulickel Ajayan has packed an entire lithium ion energy storage ... the American Chemical Society journal Nano Letters . The ... can possibly get, and could be valuable as a rechargeable ...
... July 28, 2011 BioMed Realty Trust, Inc. ... signing of a new lease with BIND Biosciences, ... Cambridge, Massachusetts.  BIND Biosciences, a biopharmaceutical company developing ... approximately 32,800 square feet of laboratory and office ...
... 2011 TriLink BioTechnologies, Inc. (TriLink) and Lucigen Corporation ... a licensing agreement for the use of TriLink,s CleanAmp™ ... TriLink,s CleanAmp™ dNTPs are an innovative approach ... dNTPs in a PCR assay with CleanAmp™ dNTPs, a ...
Cached Biology Technology:Rice scientists build battery in a nanowire 2Rice scientists build battery in a nanowire 3BioMed Realty Trust and BIND Biosciences Sign New Lease at Vassar Street Property 2BioMed Realty Trust and BIND Biosciences Sign New Lease at Vassar Street Property 3BioMed Realty Trust and BIND Biosciences Sign New Lease at Vassar Street Property 4TriLink BioTechnologies, Inc. Announces License Agreement with Lucigen Corporation 2
(Date:4/27/2015)... , Apr. 27, 2015 Profile Solutions, ... control and security systems is pleased to announce that ... as a consultant and member of its scientific advisory ... widely known as a thought leader in technology-enhanced learning ... Technology Group, and has published studies and books focused ...
(Date:4/20/2015)... , April 20, 2015 ...   Glenbeigh Records Management (GRM), Ireland,s ... with Dubai Islamic Bank. Having built up an impressive track ... now a leading player within the records management sector in ... expects to double is GCC staffbase and employ a further ...
(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... nominated for the 2015 New York Design Awards under ... Design100, New York City Design Awards are part of ... on over 2,500 ratings from the marketplace, industry and ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Va., Nov. 18 Stanley, Inc.,(NYSE: SXE ... to the U.S. federal government, today announced that it ... Corporation (NYSE: SAI ) awarded,a four-year, cost-plus-fixed-fee ... three option years are exercised. With this award, the ...
... NY, November 18, 2008 -- Researchers at the University of ... have been used to block and reverse type 1 diabetes ... of the National Academy of Sciences , was led by ... and an expert in the field of autoimmunity. "The ...
... Materials engineers have created a new type of membrane ... be used for environmental cleanup, water purification and industrial ... conventional filters for separating oil from water and works ... usually mutually exclusive. Researchers attached the material to a ...
Cached Biology News:Stanley to Continue Biometrics In-Service Engineering Support for U.S. Army 2Stanley to Continue Biometrics In-Service Engineering Support for U.S. Army 3New filtering technology has environmental, industrial applications 2New filtering technology has environmental, industrial applications 3