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First patent issues on TAL effector technology
Date:5/13/2013

EVANSTON, Ill., May 13, 2013 /PRNewswire-iReach/ -- The Two Blades Foundation (2Blades), a not-for-profit organization focused on the development and deployment of durable disease resistance for agriculture, announces the April 16th issuance of a key patent for gene editing based on the use of TAL effectors.

TAL effectors are naturally occurring proteins found in plant pathogenic bacteria that contain a novel repeat structure that binds to specific DNA sequences according to a simple cipher or 'code'.  The discovery of this code enables researchers to target proteins to virtually any DNA sequence in a genome with accuracy and ease to delete, add, alter, or regulate genes with high precision.  The TAL code technology was discovered by Ulla Bonas , Jens Boch , Sebastian Schornack , and Thomas Lahaye at Martin-Luther University in Halle, Germany.  It was named Method of the Year in 2011 by the journal Nature Methods and Best Novel Agricultural Technology in the 2012 Informa Agrow Awards.  2Blades has worked with the inventors to develop the technology and a comprehensive estate of patents.  This issued patent, U.S. Pat. No. 8,420,782, is directed to TAL effectors with endonuclease activity.

2Blades has exclusive rights for commercial uses of the technology in plants. Targeted genome modifications in plants are useful to improve agronomic traits, including disease resistance, growth and yield, or tolerance to environmental conditions such as drought. 2Blades has licensed the technology on a non-exclusive basis to a broad range of leading agricultural companies, including Bayer CropScience, DuPont-Pioneer, KWS SAAT AG, Mendel Biotechnology, Monsanto, Simplot, Syngenta Biotechnology and others. "Interest in licensing the technology for food and fuel applications continues t
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SOURCE Two Blades Foundation
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