Navigation Links
First Multiple Dose Clinical Trial of TorreyPines Therapeutics' Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated
Date:2/11/2009

Findings Support Development for Chronic Pain Indications

LA JOLLA, Calif., Feb. 11 /PRNewswire/ -- TorreyPines Therapeutics, Inc. (Nasdaq: TPTX) today announced that oral administration of NGX426, an AMPA/kainate-type glutamate receptor antagonist, was safe and well-tolerated in healthy male and female subjects when dosed once daily for five consecutive days.

"The successful completion of this Phase I trial demonstrating the safety and tolerability of NGX426 when dosed over multiple days provides support for pursuing a Phase II program in chronic indications," said Ev Graham, Chief Executive Officer of TorreyPines. "Combined with the positive results from our recently completed Phase I study of NGX426 in a capsaicin induced pain model, we are very encouraged about the potential for NGX426 to treat both acute and chronic pain conditions."

The Phase I double-blind, placebo-controlled trial enrolled 20 healthy male and female subjects in sequential, dose-escalating cohorts. Subjects received once-daily oral doses of either 90 mg or 150 mg of NGX426 or placebo for five consecutive days, approximating exposure under steady-state pharmacokinetic conditions. Overall, NGX426 was well-tolerated. There were no dose-limiting adverse events or discontinuations from the study and reported adverse events were generally mild and transient.

NGX426, an ester prodrug, is an oral form of tezampanel, TorreyPines most advanced product candidate. Pharmacokinetic analyses from two Phase I studies confirmed that when given to humans, NGX426 is rapidly converted to tezampanel, the active moiety. To date, six Phase II, double-blind, placebo-controlled trials have demonstrated that tezampanel, administered either subcutaneously or intravenously, was more effective than placebo in relieving pain across migraine, nocic
'/>"/>

SOURCE TorreyPines Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Max Muscle Introduces First-Ever Probiotics Protein Bar
2. Pharmasset Reports Fiscal First Quarter 2009 Financial Results
3. Hoya Announces Third Quarter and the First Nine Months Financial Results for FY2008
4. Historic Seed Delivery Made in Illinois for First New Soybean Varieties With the Greater Yield Potential of Roundup Ready 2 Yield(TM)
5. Peregrine Pharmaceuticals Bavituximab Achieves Primary Endpoint in First Stage of Phase II Lung Cancer Study
6. World's First Website for Patients to Share Diagnostic-Quality Medical Images
7. Victhom Human Bionics Receives CE Mark for the Neurostep(TM) System, the Worlds First Fully Implantable Closed-Loop Neuromodulation Therapy for Treatment of Foot Drop
8. BioComp Pharma Launches First Generic Drug for Tindamax(R)
9. deCODE Discovers First Genetic Variant Conferring Increased Risk of Essential Tremor
10. Complete Genomics to Release Its DNA Sequencing Data for the First Time at Advances in Genome Biology and Technology Annual Meeting
11. AMDL First to Implement US & China-Based, GAAP-Certified Accounting Technology to Capitalize on Lucrative China Healthcare Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... 2013 was a banner year of continued ... saw continued independent research led by the team at ... $1 million grant from the Susanne Marcus Collins Foundation, ... peer reviewed journal, Amy Grant highlighted Brainwave Optimization® in ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch is ... new therapy for the treatment of tinnitus. Patients listen ... frequency, and over a period of weeks to months, their ... Therapy in two forms: Notched Music and Notched White Noise. ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 ... Almshouse Road, Warrington, Pa. , Details: The Hepatitis ... finding a cure for hepatitis B and improving the quality ... Crystal Ball on Friday, April 11 at Warrington Country Club ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Histogen, Inc., ... products of cells grown under simulated embryonic conditions, today ... agreement with Suneva Medical, Inc. for physician-dispensed aesthetic products ... , This agreement is an amendment to the ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... Jordan , Caliper Life Sciences, ... Introduction , The ... Liquid Handler (ALH). This device is designed to permit individually and independently ... microplates for purposes of liquid transfer (tertiary dispensing). It can be configured ...
... Rudy Willebrords 1 and Bart Moyson ... 1 Johnson & Johnson Pharmaceutical Research & Development, a division of Janssen Pharmaceutica ... 2 Caliper Life Sciences Benelux NV, Teralfene, Belgium ... The purpose of this paper is to report ...
... Lynn Jordan , ... Introduction , ... across multi-well plates and into individual columns (secondary dispensing) is of ... precision that can be achieved during a series of dispenses. Therefore, ...
Cached Biology Technology:Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 2Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 3Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 4Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 596 Well Pipetting Precision Testing Using the Sciclone ALH with a 384 Fixed-Cannula Array 296 Well Pipetting Precision Testing Using the Sciclone ALH with a 384 Fixed-Cannula Array 3Sciclone ALH Bulk Dispense Precision Testing 2
(Date:4/24/2014)... brain infection caused by fungus could now be treated in ... University of Liverpool scientists. , Cryptococcus a ... relatively neglected in medical research. They are found in ... East Asia and mainly affect people with weakened immune systems. ... The University research team has tested the effects of the ...
(Date:4/24/2014)... with new insights into the make-up of tropical forests, ... Basin have revealed unprecedented detail of the size, age ... satellite maps with hundreds of field plots. , ... the amount of carbon each tree can store. This ... which trees are given a cash value according to ...
(Date:4/24/2014)... droplet of clear liquid can bend light, acting as ... have developed a new process to create inexpensive high ... apiece. , Because they,re so inexpensive, the lenses ... tools to detect diseases in the field, scientific research ... education in classrooms. , "What I,m really excited ...
Breaking Biology News(10 mins):Treatment for deadly yeast disease reduced to 3 days 2Amazon rainforest survey could improve carbon offset schemes 2Bake your own droplet lens 2Bake your own droplet lens 3
... kills more people than breast, colorectal, pancreatic, and prostate ... the leading cause of mortality in intensive care units. ... fatal disease. Thanks to a generous grant of $138,238.65 ... Research Institute,s Dr. Michael Sharpe is exploring a new ...
... publication of new names in algae, fungi, and plants accepted ... paper that is being published simultaneously or will be published ... paper, co-authored by Sandra Knapp (London), John McNeill (Edinburgh) and ... articles to the Code and some ideas for ...
... No, this isn,t Jurassic Park. Researchers at the Johns Hopkins ... hunter in College Park, Md., have described the fossil of ... discovered, and a founder of a new genus and species ... Cretaceous Era. Nodosaurs have been found in diverse locations worldwide, ...
Cached Biology News:Could an apple a day keep sepsis away? 2Revolutionary changes to the Botanical Code published in 16 journals and 5 languages 2Newborn dinosaur discovered in Maryland 2
... The Multiple Species Tissue Array (MSTA) slides ... different cells and tissues from multiple species. ... on each MSTA slide which can then be ... staining, immunohistochemistry, or in situ hybridization. ...
... Medium (TSB), USP is a highly nutritious ... laboratory use. Due to the inclusion of ... will support growth of many fastidious organisms ... Product conforms to United States Pharmacopeia standards ...
... The Gene Pulser Xcell ... V, 50-60 Hz, is used ... This system includes the main ... (25-3,275 microfarad range) or square-wave ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~5 kDa thymosin beta4 protein....
Biology Products: