Navigation Links
Failure of Iclusig, Ariad’s Pharmaceutical Drug, No Surprise to CBCD
Date:10/20/2013

another example of the failed “Single Target” paradigm, which is argued to be the underlying cause of the productivity crisis in pharmaceutical R&D. This paradigm is explained in a paper published on March, 2012 in the medical journal Nature Reviews. The paper said that “Much of the pharmaceutical industry's R&D is now based on the idea that high-affinity binding to a single biological target linked to a disease will lead to medical benefit in humans. Indeed, drug-like small molecules tend to bind promiscuously, and this sometimes turns out to have an important role in their efficacy as well as their so-called off-target effects. Targets are parts of complex networks leading to unpredictable effects, and biological systems show a high degree of redundancy, which could blunt the effects of highly targeted drugs (3).”

In simple terms, the idea that a drug binds with only one target is wishful thinking. As it turns out, every drug binds with many targets in the body, the desired one, and many others. Binding to the ‘other’ targets usually causes all the unwanted, surprising, side effects.

"If one doesn’t understand the complete biology of disease, aiming at one target requires praying for no collateral damage. Any drug that passes clinical trials under this paradigm is a miracle. But, miracles are rare, and unpredictable. Investors need to demand a change. They need to put an end to the “Single Target’ paradigm. Otherwise, a successful drug with no side effects will continue to remain elusive." - Greg Bennett, CBCD

In summary, the ‘Single Target’ paradigm pursued by the pharmaceutical industry is a failure. There is a growing need for a different approach.

The CBCD invites scientists, and investors interested in discussing such an approach to contact the Center at: info (at) CBCD (dot) net.

###

References:

(1)    

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. NIH media availability: Protein linked to increased risk of heart failure and death in older adults
2. Heart Failure Society of America Annual Meeting To Feature Several Satellite Symposia
3. A new treatment for kidney disease-associated heart failure?
4. Blocking digestive enzymes may reverse shock, stop multiorgan failure
5. Galectin-3 Assessed as a Biomarker of Heart Failure: Key Clinical Trial Findings Published by Dove Medical Press
6. At Three Months Post Launch, Two-Thirds of Surveyed U.S. Rheumatologists Believe that Initiations of Pfizers Xeljanz in the Rheumatoid Arthritis Treatment Algorithm Will Occur Following at Least Two Biologic Failures
7. SynCardia Total Artificial Heart Bridges Mother of Four with Congenital Heart Defect & Biventricular Heart Failure to Transplant
8. The Prevention of Heart Failure
9. Center Of Reproductive Medicine Participates In The Thrive-IVF Research Study To Help Improve Pregnancy Success Rates And Outcomes In Women With A History Of Repeated In Vitro Fertilization (IVF) Failures
10. Houston Fertility Institute Participates In The Thrive-IVF Research Study To Help Improve Pregnancy Success Rates And Outcomes In Women With A History Of Repeated In Vitro Fertilization (IVF) Failures
11. Celladon Corporation Announces Publication of Long Term Follow-Up Results from the MYDICAR CUPID 1 Trial in Advanced Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... , July 30, 2015 ... la santé, publie ses résultats pour le premier ... commente les résultats. Visionner l,interview ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Au sommaire de ... - Moteurs de croissance - ...
(Date:7/29/2015)... / Japan (Q2 2015: +14% CER / ... on high-single-digit growth in China , as well as solid ... . Europe / Middle East ... sales) showed gains in Germany , Turkey ... +4% CER / 49% of sales) grew 11%, excluding U.S. HPV sales, on ...
(Date:7/29/2015)...  AsureQuality and Ubiquitome have agreed to collaborate ... food and primary production sectors. The collaboration will ... the Freedom4. AsureQuality provides quality assurance ... shelf for producers, processors and Competent Authorities around ... control and pest management and surveillance programmes. ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... its GHS Label Guide . To align chemical container labeling with OSHA’s ... includes explanations of label components, an example of an accurate label, and pictogram ...
Breaking Biology Technology:QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Brady Announces a New GHS Label Guide 2
... , , , Multiporator / Electroporator 2510 , , , , , ... Transformation Protocol , Protocol No. 4308 915.501 04/2002 , ... , , , Microorganism , ... Cell type , Bacteria, gram negative, ...
... , , , , , , Multiporator / Electroporator 2510 , , ... , Transformation Protocol , Protocol No. ... , , , , , , ... , , Cell type , ...
... Eppendorf's Perfectprep Plasmid , Mini Kit , ... , James Griffith and Kim Vollmer , ... Vollmer, Brinkmann Instruments, Biosytems Application Lab, Westbury, , NY , , ... , Cosmids are commonly used vectors in the lab, ...
Cached Biology Technology:Actinomyces viscosus 2Actinobacillus pleuropneumoniae 2Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 2Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 3Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 4Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 5
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) has ... Market by Application, Technology, Function & Geography - Global ... The next generation biometrics market is expected to ... 17.9% between 2015 and 2020 Travel & ... Safran SA ( France ), NEC ...
(Date:6/30/2015)... June 30, 2015 Genisphere announced ... CEO to help further develop Genisphere,s therapeutics capabilities and ... experience, having spent much of the last 25 years ... Baxter Bioscience, and Johnson & Johnson. Tom started his ... and Biotech Corporate Finance. He graduated from Dartmouth College ...
(Date:6/25/2015)... , June 25, 2015 ... Market by Type (Swipe & Area), Technology, Material (Optical ... Healthcare, Commercial Security & Others) & Geography - ... marketsandmarkets, the said market is expected to reach ... 17.1%. Browse 76 market Tables ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
... Pregnant women taking prenatal supplements may not be getting enough ... Child & Family Research Institute at BC Children,s Hospital that ... . The study found that while almost 80 per ... many were vitamin D insufficient. Insufficient means that blood levels ...
... (Santa Barbara, Calif.) Viruses fill the ocean and ... microbiology, according to a professor of biology at UC ... professor with UCSB,s Department of Ecology, Evolution, and Marine ... marine viruses published this week by the International ...
... is a well-oiled machine with tiny protein motors hauling chromosomes, ... motors are responsible for a variety of critical transport jobs, ... put themselves into "energy save mode" to conserve cellular fuel ... cell, and when. A new study from ...
Cached Biology News:Pregnant women in Vancouver may not be getting enough vitamin D 2Decade-long study reveals recurring patterns of viruses in the open ocean 2Decade-long study reveals recurring patterns of viruses in the open ocean 3Carnegie Mellon scientists discover how molecular motors go into 'energy save mode' 2Carnegie Mellon scientists discover how molecular motors go into 'energy save mode' 3
Request Info...
Goat polyclonal to PINX1 ( Abpromise for all tested applications). entrezGeneID: 54984 SwissProtID: Q548A5...
...
Mouse monoclonal [7A6] to NFAT2 ( Abpromise for all tested applications). entrezGeneID: 4772 SwissProtID: O95644...
Biology Products: