Navigation Links
FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia
Date:10/22/2008

r the treatment of hyponatremia in patients with underlying heart failure when the expected benefit of raising serum sodium outweighs the increased risk of adverse events. Vaprisol is contraindicated in patients with hypovolemic hyponatremia. In addition, coadministration of Vaprisol with potent CYP3A4 inhibitors, such as ketoconazole, itraconazole, clarithromycin, ritanovir, and indinavir, is contraindicated. Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products. Serum sodium, volume, and neurological status must be monitored frequently because Vaprisol potentially can cause overly rapid correction of sodium leading to serious sequelae. The use of Vaprisol in patients with hepatic impairment (including ascites, cirrhosis, or portal hypertension) or renal impairment has not been systematically evaluated. Use caution when administering Vaprisol to these patients. The most common adverse reactions reported were infusion site reactions (incidence of 73% and 63% for 20 mg/day and 40 mg/day respectively) which were also the most common type of adverse reaction leading to discontinuation of Vaprisol. Discontinuations from treatment due to infusion site reactions were more common among Vaprisol-treated patients (3%) than among placebo-treated patients (0%). Other common adverse reactions were headaches (8%, 10%), hypokalemia (22%, 10%), orthostatic hypotension (14%, 6%), and pyrexia (11%, 5%) for Vaprisol 20mg/day and 40mg/day, respectively. For full prescribing information, please visit http://www.Vaprisol.com.

About Astellas

Astellas Pharma US, Inc., located in Deerfield, Illinois, is a US affiliate of Tokyo-based Astellas Pharma Inc., Astellas is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceutical products. The organization is committed to becoming a glob
'/>"/>

SOURCE Astellas Pharma US, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. FDA Approves Orphan Drug Status for Revolutionary Cancer Drug for Children
2. FDA Approves AstraZenecas SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania
3. FDA Approves Fougeras Clotrimazole Cream USP 1%
4. FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting
5. USDA Approves Syngenta and John Deere for Broadened Biotechnology Endorsement for Corn Crop Insurance
6. Signalife Board Approves Merger
7. FDA Approves EOVIST(R) to Detect and Characterize Focal Liver Lesions
8. FDA Approves Abbotts XIENCE(TM) V Drug Eluting Stent
9. FDA Approves ACIPHEX(R) (rabeprazole sodium) 20 mg for Short-Term Treatment of GERD in Adolescents
10. FDA Approves CONCERTA(R) (methylphenidate HCI) Extended-release Tablets for Treatment of ADHD (Attention Deficit Hyperactivity Disorder) in Adults
11. FDA Approves Quark IND for DGFi, an siRNA Therapeutic Based on Silence Therapeutics Unique Proprietary Chemistry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... , July 21, 2014  Mike Patterson, ... of $1.6 million in Series Seed B funding ... chemical sensors for the life science, defense, intelligence, ... Capital Partners led the round and was joined ... Angels.  Said Patterson , "This round of ...
(Date:7/20/2014)... recycled, the process releases radioactive krypton and xenon gases. ... related gas radon. A new porous material called CC3 ... in Nature Materials shows how: by breathing ... , The CC3 material could be helpful in ... or air in buildings and also in recycling useful ...
(Date:7/18/2014)... -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that it ... results on Tuesday, August 5, 2014, before the U.S. ... call and simultaneous webcast at 8:30 AM Eastern Time ... this call, dial (888) 660-6127 (U.S.) or (973) 890-8355 ... from the ,Events and Presentations, page of Regeneron,s website ...
(Date:7/18/2014)... neutral. That is, most of the atoms in ... electrons in the outer parts of atoms equals the ... As one or more electrons are plucked away from ... positive pull from the nucleus. This enhanced pull, ... those electrons are less vulnerable to the distractions of ...
Breaking Biology Technology:Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2A noble gas cage 2A noble gas cage 3Highly charged ions 2Highly charged ions 3Highly charged ions 4
... - A new technique inspired by elegant pop-up books ... to be mass-produced by the sheet. Devised by ... enables the rapid fabrication of not just microrobots, but ... 18 layers of carbon fiber, Kapton (a plastic film), ...
... Healthcare organizations are becoming more efficient and effective ... more connected patient care environment. But to have this ... the electronic medical record (EMR) and enterprise content management ... leader in ECM for healthcare , has a ...
... A protein that has shown early promise in preventing the ... has been found in a new study to be a key ... protein biglycan needs to be present to stabilize synapses at the ... Brown University that appears in the Feb. 14, 2012, issue of ...
Cached Biology Technology:In new mass-production technique, robotic insects spring to life 2In new mass-production technique, robotic insects spring to life 3Johns Hopkins Health System is 100th healthcare Provider to Integrate OnBase With Leading Electronic Medical Record System 2Johns Hopkins Health System is 100th healthcare Provider to Integrate OnBase With Leading Electronic Medical Record System 3When nerve meets muscle, biglycan seals the deal 2
(Date:7/22/2014)... researchers in modifying properties of nanomaterials for application in ... to recent innovative studies conducted by scientists from the ... of a simple, efficient and low cost technique involving ... by Professor Sow Chorng Haur from the Department of ... the properties of two different types of materials can ...
(Date:7/22/2014)... Stem cells offer much promise for treating damaged organs ... survival is poor, limiting their effectiveness. New methods are ... optimize their therapeutic function after transplantation, as described in ... a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. ... Open Access website . , In ...
(Date:7/22/2014)... DURHAM, N.C. In a cost-effectiveness analysis of commercial ... the drug Qsymia showed the best value for the ... loss, but was also the most expensive option tested, ... Graduate Medical School. , The findings, published in the ... important information on the health and weight-loss benefits per ...
Breaking Biology News(10 mins):NUS scientists use low cost technique to improve properties and functions of nanomaterials 2NUS scientists use low cost technique to improve properties and functions of nanomaterials 3Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3
... to save Australia’s iconic Tasmanian devils from the deadly ... Livestock Industries’ Australian Animal Health Laboratory (AAHL), Textiles and ... to hunt down the cause of Devil Facial Tumour ... infected animals. , DFTD is infectious and ...
... markers in the DNA of people with and ... researchers to identify a common gene that appears ... disease. The finding, announced today by researchers at ... Institute, Kronos Science Laboratory and their collaborative partners, ...
... dioxide emissions, but scientists at UC Irvine have determined ... explain one-third or more of the Arctic warming primarily ... soot from tailpipes, smoke stacks and forest fires enters ... is darker than natural snow. Dark surfaces absorb sunlight ...
Cached Biology News:CSIRO scientists join fight to save 'Tassie devil' 2Research team identifies new Alzheimer's gene 2Research team identifies new Alzheimer's gene 3Dirty snow may warm Arctic as much as greenhouse gases 2
... that made the original Gene Pulser apparatus and ... has been applied in the Gene Pulser II ... design of the Gene Pulser II system has ... has the widest range of settings to target ...
Experion Pro260 chips are the microfluidic chips used to perform protein analysis with the Experion automated electrophoresis system. Each chip has the capacity to run 10 protein samples. Supplied as...
... Experion Pro260 reagents and supplies, ... and supplies sufficient to perform protein ... Experion automated electrophoresis system. Supplied are ... 45 microliters Pro260 stain, 60 microliters ...
... 3000 drug discovery system miniaturizes, integrates ... Using LabChip technology, the LabChip ... serial, continuous flow fashion. LabChip assays ... results exceeds what is achievable in ...
Biology Products: