Navigation Links
Exit discovered in cellular garbage truck
Date:5/10/2013

At the University of Geneva (UNIGE), the team led by Professor Jean Gruenberg has long been interested in the movement of lysosomes, the sub-compartments of cells to where endocytic vesicles deliver their waste content and the molecules destined to be destroyed. Within this context, researcher Christin Bissig, along with her international colleagues, carried out a detailed study of the route taken by Alix which is lodged inside the endosomal membrane. This tailing has highlighted how protein contributes to avoiding cellular digestion, like a door opening into the endosomal transporter garbage bin, bringing about a final waste sorting operation which determines the cell's health. The researchers also showed how vesicular stomatitis makes use of the same route to penetrate the inside of the cell and infect it.

Finally, they identified a lipid, partnered with Alix in this process and present only in the late endosome. This is the first characterisation of the protein-lipid partnership throughout the atom.

Refuse collection and the path of life

Endosomes and lysosomes are 0.2 to 0.5 cell organelles and are present in all animal cells. Their role is to sort molecules and ensure inter-cell digestion and regulation. In all eukaryotes from yeast to human, they carry then transform or destroy proteins, lipids or sugars which the cell feeds on in order to grow and regenerate. In a certain number of diseases or conditions, lysosomes and endosomes are reached and they no longer carry out their transport or degradation work. This is particularly the case with people suffering from lysosomal diseases. The cells are then clogged with waste. The organism is deregulated, even intoxicated. This path taken by these essential refuse collectors therefore merits greater recognition and documentation.

Lodged inside the endosomes, the Alix protein takes this same route, known as endocytosis, where molecules and particles travel from the external cell membra
'/>"/>

Contact: Jean Gruenberg
jean.gruenberg@unige.ch
41-223-796-464
Universit de Genve
Source:Eurekalert

Page: 1 2

Related biology technology :

1. A Mutation Discovered in Iceland that Increases Risks of Osteoporosis and Certain Cancers
2. Undiscovered Companies Announces A Video Interview Of Hidden Bio-Tech Company Immunotech Laboratories
3. New Way to Kill Bed Bugs Discovered; Bed Bug Bully Says Use of Bed Bug Spray Remains the Better Technique to Kill the Pests
4. Millions of DNA switches that power human genomes operating system are discovered
5. Discovered Evolution of Genomic Sequences -- from Ocean Archaea to Brain Cancer -- Leads to New Synthetic Replikin Vaccines for Infectious Diseases and Cancer
6. Australian Discovered Biomarkers Map Path to New Blood Test for Bowel Cancer
7. Novel method to make nanomaterials discovered
8. Dual-acting class of antimalarial compounds discovered with potential to prevent and treat malaria
9. ASGCT Annual Meeting to Highlight Latest Advances in Genetic and Cellular Therapeutics
10. Cellular Biomedicine Group Provides Update and 2013 Milestones
11. Unique Extracellular Matrix Used in Patient Successfully Treated for Flesh Eating Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... - Sales in the First Half of 2009 (Excluding ... - Growth in the Pharma Business, - ... Laboratory Glassware, , In the first ... the continuing worldwide economic crisis. This result was,mainly attributable to sales growth ...
... Mass., July 14 Idenix Pharmaceuticals, Inc., (Nasdaq: IDIX ... the second quarter of 2009 on Monday, July 20, 2009 after ... In conjunction with the issuance of the press release, Idenix management ... July 20, 2009 to discuss the company,s financial results for the ...
... , LAKE ZURICH, Ill., July 14 ... blood collection, separation, safety and availability, announced today it has ... to market, sell and distribute Verax,s unique PanGenera(R) Detection (PGD) ... in donated blood platelets. , ...
Cached Biology Technology:Gerresheimer Holds its own in Difficult Environment 2Gerresheimer Holds its own in Difficult Environment 3Gerresheimer Holds its own in Difficult Environment 4Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test 2Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test 3
(Date:4/15/2014)... viral diseases in the world for which no pharmaceutical ... is spread by mosquitoes in the tropics, as well ... in Finland and is easily spread by the hands ... the elderly. , Researchers at Aalto University and the ... tests to prevent the spread of one type of ...
(Date:4/15/2014)... cell systems soon could be powering the forklifts used ... and with faster refueling times than ever before, courtesy ... Hydrogen Carriers (HHC). , The goal of the project ... can refuel at low pressure four to five times ... giving hydrogen a competitive advantage over batteries for a ...
(Date:4/14/2014)... swallow, but if you,re over 24 years of age ... cognitive motor performance, according to a new Simon Fraser ... doctoral student, associate professor Mark Blair, Thompson,s thesis supervisor, ... student, deliver the news in a just-published PLOS ... the first social science experiments to rest on big ...
Breaking Biology News(10 mins):Nanocrystalline cellulose modified into an efficient viral inhibitor 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 3Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 4Study says we're over the hill at 24 2
... (SACRAMENTO, Calif.) An international team of scientists led by ... cells is not a one-way street as previously believed. Their ... has a self-correcting mechanism that allows DNA to make a ... appear in the Oct. 23 online issue of the journal ...
... A peer-reviewed study commissioned by NOAA shows the American people ... the coral reefs of the main Hawaiian Islands. ... treasure Hawaii,s coral reefs, even though many never get to ... for oceans and atmosphere and NOAA administrator. "It illustrates the ...
... of Plant Biologists (ASPB) has named 12 plant biology researchers ... Science Master Plant Science Team (MPST). ... research resource that brings together middle and high school students, ... engage in hands-on plant investigations while working with peers at ...
Cached Biology News:UC Davis researchers discover complexities of DNA repair 2US residents say Hawaii's coral reef ecosystems worth $33.57 billion per year 2American Society of Plant Biologists supports science outreach by grad students and postdocs 2American Society of Plant Biologists supports science outreach by grad students and postdocs 3
Mouse polyclonal antibody raised against a partial recombinant WRB. NCBI Entrez Gene ID = 7485...
...
Mouse monoclonal to Casein Kinase 2 beta ( Abpromise for all tested applications). entrezGeneID: 1460 SwissProtID: P13862...
Mouse monoclonal antibody raised against a partial recombinant FAAH. NCBI Entrez Gene ID = FAAH...
Biology Products: