Navigation Links
ESTEVE Announces the Publication of Comprehensive Phase I Data for a Novel Oral, First-in-class New Chemical Entity (NCE),E-52862, a Sigma-1 Receptor Antagonist (S1RA) Being Developed for Pain
Date:9/4/2012

BARCELONA, Spain, September 4, 2012 /PRNewswire/ --

  • E-52862 is a potent, highly selective NCE with a novel mechanism of action (MOA; Sigma 1 Receptor (S1R) antagonism) currently being evaluated for the treatment of pain
  • Key data are outlined from three Phase I studies involving 175 male and female human subjects
  • These studies demonstrate a favourable safety, tolerability, pharmacokinetic and pharmacodynamic profile for E-52862
  • Phase II clinical trials evaluating E-52862 are ongoing

ESTEVE announces the recent publication of data from the Phase I clinical trial programme of a novel, highly potent and selective, once-daily, S1RA E-52862, developed by the ESTEVE R&D team, in the British Journal of Clinical Pharmacology[1].

     (Logo: http://photos.prnewswire.com/prnh/20120904/554843)

Mariano Sust, M.D., corresponding author, stated that "E-52862 represents a NCE with a novel, unprecedented mechanism of action for pain of different aetiologies.  We are very encouraged by these results and look forward to future findings from the E-52862 clinical trial programme in due course."

To fully validate the safety and tolerability of E-52862, ESTEVE performed a rigorous phase I programme. This publication reports results from three, Phase I studies involving 175 human subjects. E-52862 demonstrated a favourable safety and tolerability profile across a robust panel of assessments including adverse event recording following questioning and spontaneous reporting; physical examinations; vital signs measurements; laboratory safety tests (haematology, blood coagulation, biochemistry, urinalysis); multiple psychometric tests; computerized cognitive evaluations (including assessment of executive function, working memory and learning, reaction time and psychomotor functions); and thorough cardiac monitoring
'/>"/>

SOURCE ESTEVE
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. ESTEVE Communicates its R&D Through a New Interactive Platform
2. Texas Medical Center, the largest concentration of medical research, educational and healthcare organizations in the world, announces the first Houston Stem Cell Summit to highlight the latest stem cell research and commercialization efforts
3. Sangamo BioSciences Announces Presentation At The Stifel Nicolaus 2012 Healthcare Conference
4. ARMGO Pharma, Inc. announces data which supports its Rycal program as a novel approach for the treatment of stress-induced cognitive disorders
5. Bolder BioTechnology Announces Publication of Data Demonstrating Utility of the Companys Long-Acting IL-11 Analog to Prevent Renal Ischemia Reperfusion Injury
6. Clinical Site Services, Industry Leader in Patient Enrollment Solutions, Announces New Website
7. Debiopharm Announces First Patient Enrolled in Phase III Study for the Rare Disease Central Precocious Puberty
8. Pinnaclife, Inc., Announces NDC, Inc., to Exclusively Distribute the New Animal Health Product Line!
9. Elsevier / Gold Standard Announces New Drug Class Overviews for Clinical Pharmacology
10. Inspiration Biopharmaceuticals Announces New Global Commercialization Agreements with Ipsen
11. UBM Announces Partnership Agreement With Trade Organisation - SIPPO
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... , July 22, 2014  The Broad ... million from philanthropist Ted Stanley aimed ... bringing new treatments based on molecular understanding to ... The Stanley commitment – the ... largest for scientific research in general – will ...
(Date:7/22/2014)... July 22, 2014  United Therapeutics Corporation (NASDAQ: ... will release its second quarter 2014 financial results ... United Therapeutics will host a half-hour ... a.m. Eastern Time.  The teleconference is accessible by ... rebroadcast of the teleconference will be available for ...
(Date:7/22/2014)... PLAINS, New Jersey , 22. Juli 2014 ... für die Life-Sciences-Industrie, hat die Ernennung von Marcus ... bekanntgegeben. Herr Bergler hat die europäischen kommerziellen ... Lösungen unterstützt. Bevor er sich Qforma anschloss, war ... bei Cegedim Customer Information, als Vertriebsteam-Leiter Deutschland bei ...
(Date:7/22/2014)... 2014 The next session of ... and will comprise of the increasingly popular ‘Base SAS’ ... is a series of technical hands-on classes for entry-level ... reach the next step in their professional careers. , ... by Jennifer Kang, Senior Statistician at Genentech and former ...
Breaking Biology Technology:$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2Clinovo TechTrainings: Next Session of SAS and CDISC Classes Start 9th September, 2014 2Clinovo TechTrainings: Next Session of SAS and CDISC Classes Start 9th September, 2014 3
... has been awarded the International Union of Pure and ... Physics. , The award acknowledges Dr Barnard as a ... structures, shapes and crystal structures of materials at the ... Institute of Technology (RMIT) University in 2001 and ...
... Amnis Corporation, a manufacturer of advanced cell imaging ... imaging flow cytometer. The new instrument - the ... the speed, sensitivity, and phenotyping abilities of flow cytometry ... The new ImageStreamX greatly expands the capabilities of ...
... Biotech Ltd. (Amex: SVA ), a leading provider ... a conference call on Friday, May 15, 2009 at 9:00 ... for the period ended March 31, 2009 and provide an ... dial 1-877-407-4018 (USA) or 1-201-689-8471 (international). A replay of ...
Cached Biology Technology:Big prize for 'small science' physicist 2Sinovac to Host Conference Call to Report First Quarter 2009 Financial Results 2
(Date:7/21/2014)... from the strength of immune response, rather than with ... attacking the virus, might be a better way to ... of Washington, Seattle. She and her collaborators have now ... the H7N9 influenza, and their work has already led ... virulent strain. The research is published ahead of print ...
(Date:7/21/2014)... By tracking hybrids between songbird species, investigators have found ... be preventing interbreeding. The research, which is published in ... like GPS, record the position of a bird and ... Compared with their parents, hybrids exhibited increased variability in ... suitable areas, while others used the same routes as ...
(Date:7/21/2014)... apple orchards, effective management practices rely on ... competitive vegetation under the trees, and supplying ... are further complicated in organic management systems ... need to meet the stringent soil fertility ... National Organic Program. University of Arkansas scientists ...
Breaking Biology News(10 mins):Potential new flu drugs target immune response, not virus 2Organic apple orchards benefit from green compost applications 2
... a potent neurotoxin and a worrisome environmental contaminant, but ... what else is in the water. Researchers at ... of dissolved organic material increases the biological risk of ... mercury source. Mercury is present throughout the ...
... & Leuven, Belgium As the most common form ... enormous implications for our ageing society. It is generally ... (A -peptide) protofibrils. Until now, the conditions under which ... the disease remained unknown. VIB researchers have now discovered ...
... will change as carbon dioxide increases, affecting food webs along ... Centre press briefing today. Microbes in the ocean produce ... form above the sea, which reflect the suns rays away ... when they get hot so that clouds will cool them ...
Cached Biology News:Waterborne carbon increases threat of environmental mercury 2Lipids in the brain an important factor for Alzheimer's disease? 2
Complement factor B (human)...
... The AccuSpot automates LC micro-fractionation, ... With the AccuSpot system, LC eluent ... onto target plates, in trace amounts. ... target plates for MALDI-TOF-MS measurements. When ...
... LC Sciences provides a unique new tool, ... synthesis serving diverse needs in genomics, proteomics, ... OligoMix is a MIXTURE of a large ... delivered in a single microtube. OligoMix is ...
... Capillary Electrophoresis Running Buffer was designed to ... demands of todays sequencing labs. As a ... to the gel-based sequencing community Sigma has ... to meet your buffer needs. Scientists at ...
Biology Products: