Navigation Links
DermTech's Non-invasive Melanoma Detection Assay Poised to Enter Clinical Validation Study
Date:11/15/2011

LA JOLLA, Calif., Nov. 15, 2011 /PRNewswire/ -- DermTech, a biotechnology company developing non-invasive molecular diagnostics for disease detection, announced  it will present results from a study showing that its novel melanoma biomarker can be used with a high-throughput, low-cost qRT-PCR platform.  Strong earlier results using microarrays have been recapitulated on a qRT-PCR system that successfully discriminated melanoma with 100% sensitivity and 85% specificity.  Data will be reported at an oral presentation and during a poster session on November 17 at the Association for Molecular Pathology 2011 annual meeting in Grapevine, Texas.

DermTech's MelDTect™ melanoma detection test is based on the Epidermal Genetic Information Retrieval (EGIR®) approach that employs a patented adhesive-based method to obtain cells from the upper layer of the skin and genetic analysis to determine the probability of disease.  

"We saw exciting results using microarrays in our discovery work (Wachsman et al., British Journal of Dermatology, April 2011) and are pleased to report that our breakthrough approach to detecting melanoma is on course for clinical validation," said Sherman Chang, PhD, Senior Director of Molecular Biology. "Thus far in terms of accuracy, these data are better than any known detection product or products in development."

The study to be presented evaluated the suitability of a potential gene expression analysis platform along key parameters, including sensitivity, reproducibility, cost, linear dynamic range and throughput.  Using a qRT-PCR platform, it has been shown that the assays exhibited > 5-log linear dynamic range (LDR) and had a coefficient of variation (CV) < 3%.  Furthermore, 118 EGIR specimens (57 in situ and invasive melanomas, 61 nevi) were analyzed, and the 15-gene classifier was found to have an ROC AUC > 0.912 for discrimination of melanoma from nevi.

"Th
'/>"/>

SOURCE DermTech
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Auxogyn Licenses Non-invasive Embryo Assessment Technology From Stanford University
2. Dr. Suresh Koneru Introduces Zeltiq Non-Invasive Procedure For Fat Reduction
3. Doctors in New Hampshire Now Treating Cancer with Non-Invasive Image-Guided Radiosurgery Using Novalis Tx(TM) Technology
4. FDA Approves Label Change for Non-Invasive Fibroid Treatment
5. Non-Invasive Radiosurgery with Novalis Tx(TM) Platform Rolling Out Worldwide
6. Jennerex Reports Positive Mechanistic Proof-of-Concept Clinical Trial Results Using JX-594 to Treat Metastatic Melanoma
7. Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma
8. Arthritis drug could help beat melanoma skin cancer
9. Melanoma transcriptome reveals novel genomic alterations not seen before
10. U.S. Food and Drug Administration Issues Complete Response Letter Regarding PEGINTRON(R) for Malignant Melanoma
11. Oncolytics Biotech(R) Inc. Announces Reovirus and Cisplatin Research Supports U.S. Phase 2 Metastatic Melanoma Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... (PRWEB) November 26, 2014 On January, ... the Baltimore and Washington D.C. science community to the ... The event, sponsored by the Protein Society, will take ... University Center, Room 312. Through discussion, presentations and ... structural importance of proteins, their role in the industry ...
(Date:11/26/2014)... Silicon Valley Electronic Data Capture (EDC) provider ... , provider of clinical research and data management services ... to its CRO Partnership Program, Clinovo expands ClinCapture ... , “We have found Clinovo’s ClinCapture to exceed ... which is both user friendly and easy to deploy. ...
(Date:11/26/2014)... November 26, 2014 SoundConnect , ... is proud to announce that Darren Suders has joined ... Darren will drive the partner program ... experience. , Darren brings more than 10-years ... key roles in channel operations, from policy development, to ...
(Date:11/26/2014)... , 25 novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia ... mercato europeo in occasione di Hi Europe 2014 (dal ... Si tratta della curcumina con la maggiore ... (senza cristalli) e ingredienti approvati dalle norme europee. ... spezia della pianta curcumina ( Curcuma longa ) che ...
Breaking Biology Technology:RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... ("Dyadic") (OTC Pink: DYAI), a global biotechnology company focused ... and protein products for the industrial enzyme, bioenergy, and ... FibreZyme® G5000, a next generation, high performance ... quality and improve the economics of various pulp and ...
... N.Y., March 13, 2012   Health Care Compliance ... Christi Health System of Wichita, Kansas has realized ... just two months after selecting and implementing COI-SMART, ... disclosure process. (Logo: http://photos.prnewswire.com/prnh/20061010/NYTU194LOGO ...
... 8, 2012 - Researchers in applied physics have cleared ... called metamaterials, that bend light in unusual ways. ... Harvard team has used extremely short and powerful laser ... within a material. Those suspended metal dots are essential ...
Cached Biology Technology:Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference 2Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference 3Conflict of Interest Management System Selected by Via Christi Health 2Conflict of Interest Management System Selected by Via Christi Health 3Metamaterials may advance with new femtosecond laser technique 2
(Date:11/12/2014)... GARDENS, Fla. , Nov. 12, 2014 ... announced today that its U.are.U ® fingerprint readers ... bakery chain in Central Mexico . ... June 2014 to eliminate payroll issues caused by employees ... to installing the U.are.U fingerprint readers, Montparnasse relied on ...
(Date:11/7/2014)... Debra Auguste, associate professor, biomedical engineering, in the ... of New York, have identified a molecule that ... the most aggressive forms of breast cancer. , ... mortality rate owing to aggressive proliferation and metastasis ... Professor Auguste,s team, discovered the overexpression of intercellular ...
(Date:11/6/2014)... A groundbreaking paper from a team of Florida State ... how plants could adapt to and survive environmental swings ... in the latest issue of the journal The ... complex of DNA and proteins) is organized in a ... some genes are turned on and others are turned ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Maize analysis yields whole new world of genetic science 2
... of vertebrates sometimes assist a more dominant pair by ... has been shown to occur among subordinate female cichlids. ... ONE , Dik Heg and colleagues at the University ... that rather than engaging in an act of reciprocal ...
... Norman Ellstrand , a professor of genetics in UC ... been elected as one of this year,s four Botanical ... The BSA Merit Award is the society,s highest honor, ... scientists in plant biology. Some past Merit Award recipients have ...
... Princeton University,s third Art of Science competition will go live ... allows members of the public to choose their favorite 2009 ... time. The juried show features 48 works chosen from ... found here: www.princeton.edu/artofscience/2009 The theme of ...
Cached Biology News:The importance of being helpful -- Cooperative cichlids boost their own reproductive success 2UC Riverside geneticist receives highest honor from Botanical Society of America 2Exhibition showcases the 'art of science' 2Exhibition showcases the 'art of science' 3
The SmartSpec printer paper is used to record data generated by the SmartSpec Plus spectrophotometer. Supplied as 5 packs....
... arrays have been developed for affinity ... A variety of ProteinChip chemical surfaces ... to their unique biochemical properties. Each ... side-by-side sample comparison, and the chips ...
... Leu-CMK FLISP Assay with SR-101 Labeled ... nm) • Accurately measure serine protease ... permeabilization • B-Bridge's FLISP Kits utilize ... proteases (FLISPs) to measure chymotrypsin-like activity ...
... Spacer Leu-CMK FLISP Assay with FAM-Labeled ... nm) • Accurately measure serine protease ... permeabilization • B-Bridge's FLISP Kits utilize ... proteases (FLISPs) to measure chymotrypsin-like activity ...
Biology Products: