Navigation Links
Data show a decline in cystic fibrosis since introduction of prenatal carrier screening
Date:2/27/2008

A brief report in the February 28, 2008, New England Journal of Medicine, led by researchers at the New England Newborn Screening Program (NENSP) of the University of Massachusetts Medical School (UMMS), indicates a declining incidence of a genetic disease, providing what may be the first demonstration of a link between two independent population-based screening programs.

The state of Massachusetts has offered universal newborn screening to detect cystic fibrosis (CF) since 1999. Independently, recommendations for nationwide (adult) carrier screening for CF were introduced in the U.S. around 2002, coming from the National Institutes of Health, the American College of Obstetrics and Gynecology and the American College of Medical Genetics. Newborn screening for cystic fibrosis (much like newborn screening for other conditions), a public health service geared toward improving the lives of babies born with treatable conditions, identifies infants across the state who are at risk for disease and ensures that these infants are referred for diagnostic evaluation and (when appropriate) care. Tracking the number of infants who are diagnosed with the disease is an integral part of quality assurance of the newborn screening program.

Using the Massachusetts newborn screening data, the researchers compared two four-year periods: 1999 to 2002, just before prenatal CF carrier screening came into wide practice, and 2003 to 2006.

The number of live-born infants with CF dropped by about 50 percent from one four-year period to the next. Moreover, among the babies who were born with CF, markedly fewer had two copies of the delta F508 gene mutation, associated with a severe form of CF. The authors, who work closely with the clinician directors of the five Massachusetts CF Centers at Baystate Medical Center in Springfield; Childrens Hospital Boston; Massachusetts General Hospital; New England Medical Center; UMass Memorial Health Care in Worcester;
'/>"/>

Contact: Mark Shelton
mark.shelton@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Entry of Biogenerics and Decreasing Use of Amgens Epogen and Johnson & Johnsons Procrit Will Cause a $2.8 Billion Decline in the Drug Market for Chemotherapy-Induced Anemia by 2016
2. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
3. GeneGo and the Cystic Fibrosis Foundation Collaborate to Advance Understanding of Cystic Fibrosis
4. PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis
5. Cystic Fibrosis: License Agreement Boosts Development of Therapy Against Lung Infections
6. Medical Breakthrough ... Doctor Discovers Penetrating Carrier That Eradicates Fungus
7. NeoMatrix Announces Additional Funding for Breakthrough Breast Cancer Screening Test
8. BioReliance Launches Next-Generation Genotoxicity Screening Service
9. Diamics Receives European CE Mark Approval for Its Pap-Map(TM) System for Cervical Cancer Screening
10. Enigma Diagnostics to Develop Clinical Diagnostics Platform for UK National Chlamydia Screening Programme
11. Swiss Experts Recommend QuantiFERON(R)-TB Gold for Tuberculosis Infection Screening Prior to Initiating anti-TNF-a Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... Seventh Wave Laboratories, a consulting-based contract research ... products and medical devices, announced the purchase of 19 ... sq. ft. building more than three times the size ... renovations will begin immediately and the gradual transition of ... September. , “We are excited about this growth,” ...
(Date:5/21/2015)... May 21, 2015  The EveryLife Foundation for ... (R-UT) and Amy Klobuchar (D-MN) today ... Cures & Treatments, or OPEN ACT. ... advocacy organizations, this bipartisan legislation promises to rapidly ... to rare disease patients by incentivizing drug makers ...
(Date:5/21/2015)... 2015 As part of its philanthropic ... Sun Health Foundation funded a $3.25 million project to ... with the most up-to-date features and technology. , The ... pharmacy's 45 staff members will begin moving from the ... the coming days. , The current pharmacy has ...
(Date:5/20/2015)... FRANCISCO, Calif. , May 20, 2015 /PRNewswire/ ... ) today presented preliminary data demonstrating the ability ... idiopathic pulmonary fibrosis (IPF) from other interstitial lung ... findings suggest the classifier,s potential to help thousands ... to resolve ambiguity in IPF diagnosis – a ...
Breaking Biology Technology:Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 2Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 3Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5
... - Throughout the opening sessions of the 2006 Fuel ... Milwaukee, speakers criticized the State Senate for rejecting ... Joint Committee on Finance has given them one more ... no action on an ethanol incentive proposed by Governor ...
... SC Johnson has issued a cease-and-desist letter for ... of SC Johnson products for spam purposes. , ,FreeShowerCleaner.com, ... a free Scrubbing Bubbles Automatic Shower cleaner in exchange ... a global provider of household cleaning and storage products, ...
... - A collaborative project between the University of ... in Haifa has shown that thousands of sleeping ... , , Superlink-Online , a program first developed at ... the genomes of affected families, has since grown to ...
Cached Biology Technology:Joint Finance blocks Doyle ethanol measure 2Joint Finance blocks Doyle ethanol measure 3UW links with Israeli school to locate genes 2UW links with Israeli school to locate genes 3
(Date:5/21/2015)... 21, 2015 According to ... Solutions (Hardware, Software, Services), by Applications (Surveillance (Airborne, ... by End-Users (Military & Defense & Commercial) - ... Imaging Market is expected to grow from $7252.0 ... at a Compound Annual Growth Rate (CAGR) of ...
(Date:5/20/2015)... , May 20, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the addition ... the Global Iris Recognition Market"  report ... , ,This research service analyses trends ... the government and commercial sectors, globally. ...
(Date:5/19/2015)... Fingerprint Cards (FPC) has received an order for ... from one if its module partners. Deliveries are planned to ... the sensors will be used by smartphone manufacturers in ... amount to 740 MSEK to date. In addition to previously ... number of smaller orders not separately communicated amounting to more ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... 15, 2013 Originally, the label "borderline personality disorder" ... a middle ground between patients with neurotic and psychotic ... focused on the heightened emotional reactivity observed in patients ... with which they also meet diagnostic criteria for posttraumatic ...
... Fisheries managers should sharpen their ability to spot environmental ... assuming that having a certain abundance of fish assures ... the potential harvest of fish is only closely linked ... assessed in a University of Washington-led study, according to ...
... climatologists up to the year 2080 will benefit most mammals ... today if they are able to reach their new climatic ... University in a recently published article in the journal ... and Christer Nilsson of the Department of Ecology and Environmental ...
Cached Biology News:Borderline personality disorder: The "perfect storm" of emotion dysregulation 2Potential harvest of most fish stocks largely unrelated to abundance 2Potential harvest of most fish stocks largely unrelated to abundance 3
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
... Fluoroskan Ascent is a dedicated ... for all kinds of assays ... and for clinical applications. Cell ... are all important application areas. ...
... latest SpeedVac Concentrator, the SPD series takes ... new modern twist., The SPD121P SpeedVac comes ... for optimizing runs; preventing samples from freezing; ... at the end-users preset level., Standard features ...
... personal desktop unit ideal for use in laboratories ... Rotation speed set at 12 rpm , ... , Bottle capacity of four 35 x 150mm ... ,plastic bottles , Consistent, repeatable results achieved ...
Biology Products: