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Confirmation of HGT Business Day - 18th November 2008
Date:11/12/2008

LEXINGTON, Massachusetts, November 12 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, is holding an update on its Human Genetic Therapies (HGT) business for analysts and investors on 18th November 2008.

The seminar will include both an overview of Shire's overall HGT strategy and an in-depth look at the portfolio of HGT products both on the market and in development. The session will start at 9.00am (ET) and will finish at 2.30pm (ET). It is being held at Shire's HGT offices in Lexington, Massachusetts and will be webcast at http://www.shire.com. The seminar will not be providing an update on current trading. Further information on the seminar will be available on the Company's website, http://www.shire.com.

Presentations will be made by Angus Russell, Shire's Chief Executive, Sylvie Gregoire, President of Shire HGT and her senior team. In addition, Shire is pleased to announce that Pr. Marco Cicardi, M.D. University of Milan and Specialist in Angioedema will present on Hereditary Angioedema.

Notes to editors

Shire Plc

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

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