Navigation Links
Colorado Center for Reproductive Medicine Improves Pregnancy and Implantation Rates Using Comprehensive Chromosomal Screening of IVF Embryos

DENVER, Oct. 20 /PRNewswire/ -- The Colorado Center for Reproductive Medicine (CCRM) announced today a clinical pregnancy success rate of 77% for patients undergoing in vitro fertilization (IVF) with comprehensive chromosome screening (CCS), an ongoing IRB approved clinical study. The IVF pregnancy success rate is about 30% worldwide.

In May of 2007, CCRM began the CCS study, which screens for all 23 pairs of chromosomes in a few cells removed from the embryo on day 5 or 6 of development (blastocyst) using techniques that include comparative genomic hybridization (CGH) and microarray analysis. Chromosomal abnormalities are very common in human embryos, but until now, only a limited number of chromosomes could be analyzed in a blastocyst.

The goal of CCS is to reduce the likelihood of implantation failure, miscarriage and pregnancies affected with chromosomal abnormalities by preferentially transferring only embryos that have the correct number of chromosomes. "There are many variables that contribute to a successful pregnancy," said William Schoolcraft, MD, Medical Director and Founder of CCRM. "One of them is having an embryo with the correct number of chromosomes. Since a high proportion of failed pregnancies are due to abnormalities in chromosome numbers, CCS helps eliminate one variable from the equation."

Thus far, a total of 114 patients in the CCS study have had egg retrieval and subsequent frozen blastocyst transfer. Indications for the testing include advanced maternal age, previous IVF failure(s), and a history of multiple miscarriage(s). After the blastocyst embryos are biopsied, they are cryopreserved using a new technique called vitrification, which has resulted in a 97% blastocyst survival rate. The uterus is then prepared for a frozen embryo transfer after the woman's body is allowed to naturally rid itself of the ovarian stimulation drugs required during an IVF cycle. Eighty-eight of the 114 patients in the study (77%) have ongoing clinical pregnancies, including 41 healthy deliveries to date. The first baby conceived with this procedure was born in June 2008.

"We are thrilled with the outcome of our CCS clinical study," said Dr. Schoolcraft. "I am also impressed with the ability of thawed embryos to do so well after transfer in cycles unaffected by fertility drugs. With these promising early results, we are continuing the clinical trial, giving patients access to comprehensive chromosome analysis of their embryos with an increased likelihood of pregnancy."

"Although our older patients are at higher risk to produce aneuploid (chromosomally abnormal) embryos, once we identify euploid (chromosomally normal) blastocysts to transfer, these women have a similar clinical pregnancy rate as our CCS patients who are in their thirties. This is very exciting, as it gives hope for healthy pregnancy to women in their early forties," says Mandy Katz-Jaffe, PhD, Director of Research at CCRM.

Today, it is common to transfer multiple embryos, which increases the likelihood of implantation but also the chance of multiple births. A single, healthy baby is the optimal goal for both the woman's health and that of her baby. With an implantation rate (per embryo transferred) of 65%, the CCS study gives potential to make single embryo transfer a successful reality.

About the Colorado Center for Reproductive Medicine

Founded in 1987 by Dr. William Schoolcraft, the CCRM is one of the nation's leading infertility treatment centers, providing a wide spectrum of infertility treatments ranging from basic infertility care to advanced in vitro fertilization (IVF) technology. Today, joined by Drs. Eric Surrey, Debra Minjarez and Robert Gustofson, Dr. Schoolcraft and his staff achieve some of the highest pregnancy rates in the country. CCRM was ranked "The #1 Fertility Center in the U.S., with the Greatest Chance of Success" by For more information visit

SOURCE Colorado Center for Reproductive Medicine

SOURCE Colorado Center for Reproductive Medicine
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. Kaiser Permanente Colorado Opens Center for Health Dissemination and Implementation Research
2. Baxa Announces Colorado BioScience Association Sponsorship
3. Baxa Corporation Wins Two Colorado BMA 2008 Gold Key Awards
4. NIH Funds $1M Research at Quest Product Development and University of Colorado for New Digitally-Controlled Endoscopes
5. Matthew B. Wiener, CEO of Pharmatech, Inc., Is Awarded the Cancer Leadership Award From the Colorado Cancer Coalition
6. Dynamic Signs Asset Acquisition Deal With Cannex and Brings Onboard Leading Medical Cannabis Research Scientist Dr. Robert Melamede, Former Chairman of the Biology Department, University of Colorado
7. Dr. Lawrence Spivack, a LASIK Eye Surgeon Expert Serving Denver, Colorado, Joins Elite Circle of Surgeons Listed at Trusted LASIK Surgeons
8. Colorado Stem Cell Awareness Rally to Take Place in Denver, Colorado on June 13th, 2009
9. Childrens Hospital in Colorado Rounds off List of 24 Cord Blood Transplant Centers Worldwide Enrolling for ExCell Trial Studying StemEx(R) for Leukemia and Lymphoma
10. BioLife Solutions Announces Exclusive CryoStor(TM) Supply Agreement With the New England Cryogenic Center, Inc.
11. Baxa Announces 2008 Dates for STAR Center Professional Pharmacy and Cleanroom Training
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and ... clinical trial team. , Using the CONSULT module, patients and physicians can schedule a ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks ... to industrial engineering, was today awarded as one ... selection of the world,s most innovative companies. Ginkgo ... scale for the real world in the nutrition, ... engineers work directly with customers including Fortune 500 ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
Breaking Biology Technology:
(Date:5/24/2016)... superior patient care by providing unparalleled technology to leaders of the medical imaging industry. ... recently added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
Breaking Biology News(10 mins):