Colorado Center for Reproductive Medicine Improves Pregnancy and Implantation Rates Using Comprehensive Chromosomal Screening of I... ( DENVER Oct. 20 /- The Colorado Center...)

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Colorado Center for Reproductive Medicine Improves Pregnancy and Implantation Rates Using Comprehensive Chromosomal Screening of IVF Embryos

Date:10/20/2009

DENVER, Oct. 20 /PRNewswire/ -- The Colorado Center for Reproductive Medicine (CCRM) announced today a clinical pregnancy success rate of 77% for patients undergoing in vitro fertilization (IVF) with comprehensive chromosome screening (CCS), an ongoing IRB approved clinical study. The IVF pregnancy success rate is about 30% worldwide.

In May of 2007, CCRM began the CCS study, which screens for all 23 pairs of chromosomes in a few cells removed from the embryo on day 5 or 6 of development (blastocyst) using techniques that include comparative genomic hybridization (CGH) and microarray analysis. Chromosomal abnormalities are very common in human embryos, but until now, only a limited number of chromosomes could be analyzed in a blastocyst.

The goal of CCS is to reduce the likelihood of implantation failure, miscarriage and pregnancies affected with chromosomal abnormalities by preferentially transferring only embryos that have the correct number of chromosomes. "There are many variables that contribute to a successful pregnancy," said William Schoolcraft, MD, Medical Director and Founder of CCRM. "One of them is having an embryo with the correct number of chromosomes. Since a high proportion of failed pregnancies are due to abnormalities in chromosome numbers, CCS helps eliminate one variable from the equation."

Thus far, a total of 114 patients in the CCS study have had egg retrieval and subsequent frozen blastocyst transfer. Indications for the testing include advanced maternal age, previous IVF failure(s), and a history of multiple miscarriage(s). After the blastocyst embryos are biopsied, they are cryopreserved using a new technique called vitrification, which has resulted in a 97% blastocyst survival rate. The uterus is then prepared for a frozen embryo transfer after the woman's body is allowed to naturally rid itself of the ovarian stimulation drugs required during an IVF cycle. Eighty-eight of the 114 patients i
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