Navigation Links
ChanTest Develops New Cardiotoxicity and Contractility Assay with Human Stem Cell Cardiomyocytes
Date:5/14/2013

Cleveland, OH (PRWEB) May 14, 2013

Cardiovascular (CV) toxicity is a leading contributor to drug withdrawal and late-stage attrition in the drug discovery process. There is an urgent need for novel in vitro assays that enable earlier and broader testing for CV activity.

The most relevant cells for pre-clinical testing are human cells. Use of these cells has the potential to add significant efficiencies, reduce animal use and decrease the number of dangerous drugs that reach the market.

In response to this need, ChanTest has developed a new assay using ACEA Bioscience’s xCELLigence System (San Diego, CA) and human induced pluripotent stem cell (iPSC) derived cardiomyocytes from Cellular Dynamics International (CDI, Madison, WI). Based on an extensive research program, ChanTest has created several unique algorithms for twitch detection and kinetic analysis, and has concluded an investigation that suggests twitch impedance is a sensitive tool to assess contraction in a relatively high-throughput assay.

The studies concluded that the impedance twitch recordings accurately reflect key elements of contraction, thus allowing the study of drugs that affect excitation-contraction coupling and the contractile apparatus. In addition, since impedance signals can be recorded over long periods of time, deleterious long-term drug effects, such as those commonly observed for oncology drugs, can be easily evaluated with this label-free procedure. Therefore, the new ChanTest assay, applied to iPSC derived cardiomyocytes, offers an effective non-invasive screen for the cardiotoxicity and contractility.

"We listened to the requests of the pharmaceutical industry for a human cell based cardiotox and contractility assay," explained Chris Mathes, Ph.D., Chief Commercial Officer at ChanTest. "This new assay fulfills th
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. ChanTest Announces a Complimentary Webinar on the Use of the xCELLigence System
2. ChanTest Announces Their Second User Meeting: Partnerships in Drug Discovery
3. ChanTest Introduces the CardioChannelGram™ and SaVety Assessment
4. NASA develops super-black material that absorbs light across multiple wavelength bands
5. UCLA team develops highly efficient method for creating flexible, transparent electrodes
6. Ecology Coatings Develops Coatings Safe for Direct Contact with Food Products
7. Quanterix Develops Microfluidic Consumable That Will Enable Next Generation Molecular Diagnostic Systems based on Single Molecule Array Technology
8. Harvards Wyss Institute develops DNA nanorobot to trigger targeted therapeutic responses
9. College Chairman And Prolific Inventor Develops Life-Saving, Real-Time Diagnostic Technologies
10. Union Equity, Inc.s Wholly Owned Subsidiary Develops Cream that Aids in Soothing the Symptoms of Chemotherapy
11. Medi-Solve Coatings Develops Masking Process for Medical Devices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/25/2015)... 2015 An increase of awareness related ... forms of food nutrients, regulatory changes and concerns related ... in demand for natural astaxanthin over the past few ... up their capacities to satisfy the rising demand. ... source astaxanthin (used in nutraceuticals, aqua feed, food and ...
(Date:3/25/2015)... the HAGUE, Netherlands , March 25, ... LES Stimulation therapy for chronic gastro-esophageal reflux disease (GERD) ... [ Surgery . 2015; 157(3):556-567 ], establishing ... therapy. The study included 25 patients ... years and taking prescribed daily proton pump inhibitor (PPI) ...
(Date:3/25/2015)... Proove Biosciences , a commercial and research ... success of their commercially supported symposium, Personalized Medicine ... Management of Pain, at the 31st Annual American Academy ... Thursday, March 19th, 2015. , The symposium’s ... Webster , M.D., former Florida Society of Interventional Pain ...
(Date:3/25/2015)... DNA Spectrum , a leading consumer ... product earlier this year. This consumer offering is designed ... currently stands. It does so through analysis of customers’ ... affect physical fitness. Once this analysis is completed, myDNA ... effects with the client's body profile and the latest ...
Breaking Biology Technology:Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 3DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 4
... SAN DIEGO, Nov. 8, 2010 Vet-Stem, Inc. announced ... LTD (AVSC) has been completed which secures Vet-Stem,s third ... veterinarians for treating horses, dog and cats.  AVSC is ... services in Australia, New Zealand and Singapore.   ...
... Savara Inc., an inhalation product development company, today ... Board of Directors. In 1983 Mr. Hawkins ... guided the growth of that organization to over 700 ... largest clinical contract research organizations in the world. Since ...
... ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var r ...
Cached Biology Technology:Vet-Stem Signs License Agreement With Affiliate in Australia for Veterinary Stem Cells 2Savara Announces Appointment of Pharmaceutical Veteran to Board of Directors 2OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 2OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 3OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 4OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 5OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 6OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 7OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 8OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 9
(Date:3/23/2015)...   HOYOS Labs , a leading global authentication ... the Company will demonstrate multiple biometrics-based technologies under its ... Connect:ID on March 23 through 25, 2015, in ... the IEEE Biometric Open Protocol Standard; free biometrics-based consumer ... control system. BOPS was invented by HOYOS Labs and ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report to ... for Iris Biometrics in US$ Thousands. The report provides separate ... Japan , Europe , ... , and Latin America . ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... with environmental threats like bad weather, predators or oil ... researchers have analyzed blood samples to detect corticosterone levels ... have shown that corticosterone spikes can also be detected ... in the May 11 online edition of " Journal ...
... From hot pink to traditional French and Lady Gaga,s sophisticated ... But they are not just pretty when nails appeared ... million years ago, they led to the development of critical ... the ability to grasp, whether it,s a nail polish brush ...
... has seeded the Salk Institute as the number one research ... plant biologists, Joe Ecker, Ph.D., Joanne Chory, Ph.D. Jeff Long, ... the number of highly cited papers with the most impact, ... world with the greatest number of highly cited papers (top ...
Cached Biology News:A tool to measure stress hormone in birds -- feathers 2Researchers discover oldest evidence of nails in modern primates 2Researchers discover oldest evidence of nails in modern primates 3Salk Institute named global leader in plant biology research 2
Recognizes the ~115 kDa NMDA receptor NR1 subunit in rat cortex tissue extracts....
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
... joining of two strands of DNA between ... adjacent nucleotides in either a cohesive-ended or ... been shown to catalyze the joining of ... strand in a duplex molecule but will ...
... Darkroom is designed for imaging of chemiluminescent, ... systems offer direct control for users who ... by hand , A range of high ... for all fluorescent and chemiluminescent applications ...
Biology Products: