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Caris Life Sciences Adds Next-Generation Sequencing to Enhance Evidence-Based Tumor Profiling Service for Cancer Patients
Date:1/28/2013

atient cases, averaging more than 25 possible clinically-actionable biomarkers per patient.

"Evaluating DNA only doesn't address the true complexity of the biology driving the cancer. It is essential to consider the significant impact of RNA and downstream alterations of the proteins involved in each patient's disease," said David D. Halbert , Chairman and Chief Executive Officer of Caris Life Sciences. "It's imperative to perform a holistic and comprehensive analysis on a tumor, especially the proteins, which are the active agents.  Anything less does a disservice to the treating physician and could potentially put a patient at risk."

"Integrating next-generation sequencing further demonstrates our commitment to continually evolve with emerging science to provide our physicians with an unmatched comprehensive tumor profiling service," said Tom Spalding , Senior Vice President & Group Head, Oncology, Caris Life Sciences. "As a result of this comprehensive approach, we believe we can provide significantly greater clinical utility than services that solely rely on single technology platforms. For example, NGS analysis alone would not provide oncologists with key insights into some of the most commonly used companion diagnostics, as FDA-approved labeling requires the use of specific and varied profiling technologies."

NGS will power the mutational analyses performed in the company's Select and Comprehensive profiles, enabling rapid examination and broader detection of somatic mutations across hundreds of hotspots in the cancer genome. Additionally, this critical technology enables the inclusion of emerging biomarkers that may have potential clinical or research applications. The addition of these emerging biomarkers will further enhance the utility of the Caris Registry®, which houses critical data on biomarker, drug and patient outcom
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