Researchers have made a breakthrough discovery in identifying the world's most sensitive nanoparticle and measuring it from a distance using light. These super-bright, photostable and background-free nanocrystals enable a new approach to highly advanced sensing technologies using optical fibres.
This discovery, by a team of researchers from Macquarie University, the University of Adelaide, and Peking University, opens the way for rapid localisation and measurement of cells within a living environment at the nanoscale, such as the changes to a single living cell in the human body in response to chemical signals.
Published in Nature Nanotechnology today, the research outlines a new approach to advanced sensing that has been facilitated by bringing together a specific form of nanocrystal, or "SuperDot" with a special kind of optical fibre that enables light to interact with tiny (nanoscale) volumes of liquid.
"Up until now, measuring a single nanoparticle would have required placing it inside a very bulky and expensive microscope," says Professor Tanya Monro, Director of the University of Adelaide's Institute for Photonics and Advanced Sensing (IPAS) and ARC Australian Laureate Fellow. "For the first time, we've been able to detect a single nanoparticle at one end of an optical fibre from the other end. That opens up all sorts of possibilities in sensing."
"Using optical fibres we can get to many places such as inside the living human brain, next to a developing embryo, or within an artery ‒ locations that are inaccessible to conventional measurement tools.
"This advance ultimately paves the way to breakthroughs in medical treatment. For example, measuring a cell's reaction in real time to a cancer drug means doctors could tell at the time treatment is being delivered whether or not a person is responding to the therapy."
The performance of sensing at single molecular level had previously been limi
|Contact: Tanya Monro|
University of Adelaide