Navigation Links
Bioengineers develop bacterial strain to increase ethanol biofuel production

Georgia, US - A team of Bioengineers in the United States have modified a strain of bacteria to increase its ability to produce ethanol. The research, published in Biotechnology and Bioengineering, reveals how adaptation and metabolic engineering can be combined for strain improvement, a positive development for the biofuel industry.

The team focused their research on Zymomonas mobilis, a bacterium noted for its bio-ethanol producing potential. However, the team believed that ethanol production could be increased through improvement of xylose fermentation.

"Zymomonas mobilis is a superb ethanol producer with productivity exceeding yeast strains by several fold," said lead author Rachel Chen from the Georgia Institute of Technology. "In this study we sought to improve ethanol production by enhancing the ability of Z. mobilis to use and ferment xylose. Fermenting xylose at high concentration could in turn increase ethanol concentration, resulting in much improved productivity."

The team found that by metabolically altering the strain, sugar fermentation time was reduced from over 110 hours to about 35 hours. This improvement in fermentation allowed the strain to ferment higher concentrations of xylose.

"This demonstrated increase in fermentation and xylose utilization enabled us to produce ethanol to a concentration of 9% (w/v), the highest ever shown for this organism in mixed sugar fermentation," said Chen.

This research also investigated the underlying mechanism for the improvement. Interestingly, by adapting a strain in a high concentration of xylose, significant alterations of metabolism occurred.

One noticeable change was reduced levels of xylitol, a byproduct of xylose fermentation which can inhibit the strain's xylose metabolism. In addition, the first step of xylose metabolism, believed to be the rate-limiting step, was accelerated 4-8 times in the adapted strain, with the net effect of channeling xylose to ethanol instead of xylitol.

"This research illustrates the power of adaptation in strain improvement," concluded Chen. "This confirms that xylitol metabolism is the key to efficient use of xylose in this bacterium, which in turn can be vital for producing ethanol. This shows that adaptation is not only useful in improving strains, but is equally useful for pinpointing key bottlenecks in metabolically engineered strains."


Contact: Ben Norman

Related biology technology :

1. QuantaLife, Inc. Closes $17.2M Series B Financing to Accelerate Application Development for Its Droplet Digital™ PCR Platform and Establish Commercial Operations by 2011
2. Shrink Nanotechnologies Shrink Chips Cell Culturing Unit Enters Into Exclusive Development and Manufacturing Agreement with EV Group to Commercialize the StemDisc Platform
3. Shrink Nanotechnologies Enters Into Exclusive Development and Manufacturing Agreement With EV Group to Commercialize Stem Disc Platform
4. Chimerix Presents Update on CMX001 Development to the World Health Organization Advisory Committee on Variola Virus Research
5. Pitt-led team develops nanoscale light sensor compatible with Etch-a-Sketch nanoelectronic platform
6. Argos Therapeutics to Present Corporate Overview and Next Steps in Clinical Development of Arcelis™ Immunotherapy at Lazard Capital Markets 7th Annual Healthcare Conference
7. Cardium Reports on Third Quarter 2010 Financial Results and Recent Developments
8. Advanced Life Sciences Submits Full Proposal to NIAID for Development of Intravenous Formulation of Restanza as a Biodefense Countermeasure
9. Transgenomic Develops New Assays to Detect EGFR Mutations Using COLD-PCR
10. U.S. Government Grants Awarded for Further Development of Adult Stem Cell Products
11. Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success
Post Your Comments:
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free ... and will showcase its product’s latest features from June 26 to June 30, ... poster on Disrupting Clinical Trials in The Cloud during the conference. DIA ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
(Date:6/23/2016)... 23, 2016 adds ... to its pharmaceuticals section with historic and forecast ... much more. Complete report on the ... profiling 15 companies and supported with 261 tables ... . The Global Cell Culture ...
(Date:6/22/2016)... Research and Markets has announced the addition of the "Biomarkers: ... The global biomarkers market has grown ... market is expected to grow at a five-year compound annual growth ... billion in 2015 to $96.6 billion in 2020. ... 2020) are discussed. As well, new products approved in 2013 and ...
Breaking Biology Technology:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
Breaking Biology News(10 mins):