Navigation Links
Bacterial resistance to antibiotics: The more they resist, the more they divide
Date:7/29/2011

The number of multiresistant strains of bacteria in hospitals is increasing. Bacteria acquire resistance to antibiotics through mutations in their chromosomes and by incorporating new genes, either from the surrounding environment or from other bacteria. Now, a research team at the Portuguese CBA research (University of Lisbon) and the Instituto Gulbenkian de Cincia has shown that, surprisingly, when both mechanisms of resistance are playing out in the bacterium Escherichia coli (E. coli), its ability to survive and reproduce is increased. These results are now ublished in the open-access journal PLoS Genetics on July 28th(*).

Usually, the acquisition of new genes, either through the insertion of pieces of DNA called plasmids or through mutations, comes at a cost to the bacteria, reflected in a reduction in its rate of cell division, for example. Francisco Dionsio, senior author of the paper, describes the process using the following analogy: "if you disassembled your computer and randomly changed connections and pieces, you wouldn't expect it to work better than before."

However, Francisco and his colleagues show that, when a mutation occurs in the chromosome of a bacterium that has already incorporated a resistance-carrying plasmid, the bacteria divide faster in 10% of the mutation-plasmid combinations tested. Similarly, bacteria that first acquire resistance to antibiotics through mutation of their chromosome and then gain further resistance by insertion of plasmids into their DNA show reproduction rate increases in 32% of combinations.

In 2009, the same research groups showed, for the first time, the importance of interactions between random genes in determining antibiotic resistance in bacteria. This latest study takes their initial findings a step further, by demonstrating that this is a general phenomenon, and thus may help to predict how a bacterial population will evolve after receiving a plasmid th
'/>"/>

Contact: Silvia Castro
sacastro@igc.gulbenkian.pt
351-214-464-537
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Gene against bacterial attack unravelled
2. Anacor Achieves Milestone from GSK for Boron-Based Systemic Antibacterial Product Candidate
3. DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors
4. Broad-Spectrum Antibacterial Activity is the Most Important Driver of Antibiotic Selection for Nosocomial Pneumonia In Europe
5. Advanced Life Sciences Receives FDA Guidance on Approval Pathway for Restanza in Community Acquired Bacterial Pneumonia and Biodefense Indications
6. Biologists discover an extra layer of protection for bacterial spores
7. Scientists ID bacterial genes that improve plant growth
8. First Self-Replicating, Synthetic Bacterial Cell Constructed by J. Craig Venter Institute Researchers
9. Synthetic Genomics Inc. Applauds the Venter Institutes Work in Creating the First Synthetic Bacterial Cell
10. Scientists boot up a bacterial cell with a synthetic genome
11. Biologists discover an extra layer of protection for bacterial spores
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial resistance to antibiotics: The more they resist, the more they divide
(Date:10/19/2014)... Mass. , Oct. 19, 2014 NextCODE Health, ... the whole genome in real time, today announced the launch ... NextCODE Exchange , at the American Society of Human ... . To learn more, sign up and apply for free ... its unique features and benefits can be viewed here ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
(Date:10/19/2014)... report "Chocolate, Cocoa Beans, Lecithin, Sugar and Vanilla Market ... (2011 - 2016)," analyzes the chocolate market by ... market drivers, restraints, and opportunities for the chocolate market ... chocolate market is expected to grow from $83.2 billion ... CAGR of 2.7% from 2011 to 2016. , Get ...
(Date:10/19/2014)... 19, 2014 The report "Unmanned ... Homeland Security), Technology, Payload, Type & by Geography ... the global unmanned ground vehicle market into various ... of market sizes. The report also identifies the ... impacting it along with the adoption trends. , ...
Breaking Biology Technology:The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
... March 7, 2011 Reportlinker.com announces that a ... catalogue: Biomarkers - Technologies,markets and ... SummaryThis report follows the broad definition ... be objectively measured and evaluated as an indicator ...
... 7, 2011 Gene Codes Corporation has pulled back ... release of Sequencher® with support for Next Generation Sequencing ... of Biomolecular Resource Facilities [ABRF] in San Antonio, Gene ... SOLiD, Illumina and 454 instruments. Conference attendees were given ...
... measurement in the world of nanoparticles has now become a ... The UCSB research team has developed a new instrument ... a few tens of nanometers. The study will be published ... appear in the April print issue of the journal. ...
Cached Biology Technology:Reportlinker Adds Biomarkers - Technologies, Markets and Companies 2After the ABRF Conference: Gene Codes Flooded with Requests for Early Access to NextGen Software Tools 2After the ABRF Conference: Gene Codes Flooded with Requests for Early Access to NextGen Software Tools 3New instrument keeps an 'eye' on nanoparticles 2
(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... and Mary,s Virginia Institute of Marine Science have ... Protection Agency to identify the streams and wetlands ... tools to help local governments and citizens conserve ... on a dataset of tidal-marsh observations first gathered ... this historical baseline can today,s researchers accurately map ...
(Date:10/16/2014)... the bowel lining develops and, in the process, suggested ... The researchers produced evidence that stem cells are responsible ... feature of the bowel lining, and believe these stem ... finding as scientists are still divided on the stem ... Wee Tan and Professor Tony Burgess from the Walter ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... to stop the spread of drug resistance in typhoid fever, ... published in the journal eLife . The ... bacteria can out-compete drug sensitive strains when grown in the ... is transmitted by consuming food or drink that is contaminated ...
... 9, 2013 /PRNewswire-iReach/ -- With the holiday season comes the ... American will put on up to five pounds in just ... CDC (Center for Disease Control) more than 65% of Americans ... obese. (Photo: http://photos.prnewswire.com/prnh/20131209/MN29878 ) ...
... inhibitors (SSRIs) are the most commonly prescribed antidepressants, but ... often try several different SSRI medications, each with a ... is effective. It takes three to four weeks to ... and their families continue to suffer. Now researchers ...
Cached Biology News:Antibiotic-resistant typhoid likely to spread despite drug control program 2HCG Injections and B12 shots now in stock at US Vitamin Injections Site 2A personal antidepressant for every genome 2A personal antidepressant for every genome 3
Cell Culture Flask, nontreated polystyrene...
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
...
... This high pressure gradient system ... piston pumps and the Adept CE 4200 dual ... and data processing is provided by PowerStream data ... heater/chillers can be supplied. The supplied ...
Biology Products: