Navigation Links
Bacterial resistance to antibiotics: The more they resist, the more they divide
Date:7/29/2011

The number of multiresistant strains of bacteria in hospitals is increasing. Bacteria acquire resistance to antibiotics through mutations in their chromosomes and by incorporating new genes, either from the surrounding environment or from other bacteria. Now, a research team at the Portuguese CBA research (University of Lisbon) and the Instituto Gulbenkian de Cincia has shown that, surprisingly, when both mechanisms of resistance are playing out in the bacterium Escherichia coli (E. coli), its ability to survive and reproduce is increased. These results are now ublished in the open-access journal PLoS Genetics on July 28th(*).

Usually, the acquisition of new genes, either through the insertion of pieces of DNA called plasmids or through mutations, comes at a cost to the bacteria, reflected in a reduction in its rate of cell division, for example. Francisco Dionsio, senior author of the paper, describes the process using the following analogy: "if you disassembled your computer and randomly changed connections and pieces, you wouldn't expect it to work better than before."

However, Francisco and his colleagues show that, when a mutation occurs in the chromosome of a bacterium that has already incorporated a resistance-carrying plasmid, the bacteria divide faster in 10% of the mutation-plasmid combinations tested. Similarly, bacteria that first acquire resistance to antibiotics through mutation of their chromosome and then gain further resistance by insertion of plasmids into their DNA show reproduction rate increases in 32% of combinations.

In 2009, the same research groups showed, for the first time, the importance of interactions between random genes in determining antibiotic resistance in bacteria. This latest study takes their initial findings a step further, by demonstrating that this is a general phenomenon, and thus may help to predict how a bacterial population will evolve after receiving a plasmid th
'/>"/>

Contact: Silvia Castro
sacastro@igc.gulbenkian.pt
351-214-464-537
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Gene against bacterial attack unravelled
2. Anacor Achieves Milestone from GSK for Boron-Based Systemic Antibacterial Product Candidate
3. DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors
4. Broad-Spectrum Antibacterial Activity is the Most Important Driver of Antibiotic Selection for Nosocomial Pneumonia In Europe
5. Advanced Life Sciences Receives FDA Guidance on Approval Pathway for Restanza in Community Acquired Bacterial Pneumonia and Biodefense Indications
6. Biologists discover an extra layer of protection for bacterial spores
7. Scientists ID bacterial genes that improve plant growth
8. First Self-Replicating, Synthetic Bacterial Cell Constructed by J. Craig Venter Institute Researchers
9. Synthetic Genomics Inc. Applauds the Venter Institutes Work in Creating the First Synthetic Bacterial Cell
10. Scientists boot up a bacterial cell with a synthetic genome
11. Biologists discover an extra layer of protection for bacterial spores
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial resistance to antibiotics: The more they resist, the more they divide
(Date:7/24/2014)... Bound Brook, NJ (PRWEB) July 24, 2014 ... expects to manage numerous projects in the MENA region ... delighted to have a preferred provider agreement with DZS ... in the MENA region,” said Global VP of R&D ... "DZS has developed excellent operational practices with a ...
(Date:7/23/2014)...  Sangamo BioSciences, Inc. (NASDAQ: SGMO ) ... accomplishments. For the second quarter ended ... of $7.0 million, or $0.10 per share, compared to ... share, for the same period in 2013. As of ... marketable securities and interest receivable of $236.7 million. ...
(Date:7/23/2014)... ANGELES , July 23, 2014 /PRNewswire-iReach/ -- Think ... cognitive performance for the long term. They are the ... edge of sustained energy as an alternative to the ... Think Drinks on Indiegogo on July 29, 2014, with ... 30-day campaign. Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
(Date:7/23/2014)... 2014  Having the right people at the table ... business growth and achieving clinical and operational goals. The ... Summit, July 20-22, 2014, in San Diego ... and healthcare experts discussing how partnerships have positively impacted ... & Chief Executive Officer of Cape Regional Medical Center ...
Breaking Biology Technology:SBI Pharmaceuticals Co. Ltd. Enters into Preferred Provider Agreement with DZS Clinical Services 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 4Sangamo BioSciences Reports Second Quarter 2014 Financial Results 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 6Sangamo BioSciences Reports Second Quarter 2014 Financial Results 7Sangamo BioSciences Reports Second Quarter 2014 Financial Results 8Sangamo BioSciences Reports Second Quarter 2014 Financial Results 9truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2
... Optimal for Expansion in Medical Imaging Management , ... BIRMINGHAM, Ala., June 4 Optimal Reading Services Group, ... services for hospitals, imaging centers and radiology groups, announced ... made a substantial investment in Optimal. The investment provides ...
... 4 Ratcliff promoted Jorge Burbano to senior associate and ... this month. The award-winning firm ( http://www.ratcliffarch.com ... design and planning services to healthcare, academic and civic clients ... LEED(R) AP, has more than 20 years of architectural design ...
... , , SAN DIEGO, June 4 Neurocrine ... Kevin Gorman, President and Chief Executive Officer of Neurocrine Biosciences ... Conference in New York. , , The live ... Eastern Time (ET)/10:30 a.m. Pacific Time (PT). The presentation ...
Cached Biology Technology:Optimal Reading Services Group, Inc. Receives Investment from Health Evolution Partners 2Optimal Reading Services Group, Inc. Receives Investment from Health Evolution Partners 3Ratcliff Promotes Jorge Burbano to Senior Associate; Tess Kavanagh and Tony Keung to Associate 2Neurocrine Biosciences to Present at the 8th Annual Needham Life Sciences Conference 2
(Date:7/24/2014)... NEW BRUNSWICK, N.J. A yearlong study funded by ... at the Edward J. Bloustein School of Planning and ... property owners in Sandy-affected towns are skeptical about the ... 400 online survey respondents, 45 percent indicated they were ... town affected by Superstorm Sandy would be rebuilt better ...
(Date:7/24/2014)... is available in German . ... 300 million asthma sufferers worldwide, a further 600 million ... of the global population contending with allergic rhinitis (allergic ... also affect other organs and parts of the body ... intestine (in the form of inflammatory bowel diseases such ...
(Date:7/24/2014)... July 24, 2014 NXT-ID, Inc., (NXTD: OTCQB) a biometric ... its next generation smart wallet, Wocket™, was recently the topic of  ... interviewed Gino Pereira , CEO of NXT-ID, ... Mr. Gino Pereira explains ... of credit cards and walks host Anita Finley ...
Breaking Biology News(10 mins):Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2New drugs to combat asthma and the like 2New drugs to combat asthma and the like 3Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 2Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 3Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 4
... Scientists (AAPS) is a professional, scientific society of ... and other research institutes worldwide. Founded in 1986, ... exchange of knowledge among scientists to enhance their ... programs, on-going education, information resources, opportunities for networking, ...
... has to work 17 times harder to catch the same amount ... were powered by sail, according to new research. Researchers from ... UK Government data on the amount of fish caught and the ... to analyse the change in fish stocks since 1889. ...
... An experienced fruit fly researcher can tell at a glance ... distinct pigmentation pattern on a fly,s body (a type of bristle ... genitalia are dead giveaways. But most of the fly,s body parts ... no idea whether "maleness" or "femaleness" extended to all of the ...
Cached Biology News:Fishing fleet working 17 times harder than in 1880s to make same catch 2Male or female? In flies, some cells can't tell 2Male or female? In flies, some cells can't tell 3
2,4,6-Trinitrophenyl hapten is conjugated to Bovine Serum Albumin protein through lysine by amide bonds....
EoProbe Eosinophil Staining Kit, 1 Kit...
B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other ...
...
Biology Products: