Navigation Links
Assembling cells into artificial 3-D microtissues, including a tiny gland
Date:3/5/2009

se specific DNA strands onto the cells, they used chemical reactions that do not interfere with cellular chemistry but nevertheless stick desired chemicals onto the cell surface. The technique for adding unusual but benign chemicals to cells was developed by Bertozzi more than a decade ago based on a chemical reaction called the Staudinger ligation.

After proving that they could assemble cells into microtissues, Gartner and Bertozzi constructed a minute gland analogous to a lymph node, for example such that one cell type secreted interleukin-3 and thereby kept a second cell type alive.

"What we did is build a little miniaturized, stripped-down system that operates on the same principle and looks like a miniaturized lymph node, an arrangement where two cells communicate with each another and one requires a signal from the other," she said. "The critical thing is that the two cells have to have a cell junction. If you just mix the cells randomly without connection, the system doesn't have the same properties."

She expects that eventually, clusters could be built on clusters to make artificial organs that someday may be implanted into humans.

"Our method allows the assembly of multicellular structures from the bottom up. In other words, we can control the neighbors of each individual cell in a mixed population," she said. "By this method, it may be possible to assemble tissues with more sophisticated properties."

One interesting aspect of the technique is that DNA hybridization seems to be temporary, like a suture. Eventually, the cells may substitute their own cell-cell adhesion molecules for the DNA, creating a well-knit and seemingly normal, biological system.


'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Self-assembling polymer arrays improve data storage potential
2. Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells
3. Reovirus Infection of Melanoma Cells Generates Anti-Tumour Immunity
4. Scientists synthesize memory in yeast cells
5. BioLife Solutions CryoStor(TM) Adopted by Tissue Regeneration Therapeutics for Preservation Protocol for New, Non-Embryonic Source of Stem Cells
6. Patent Office Rules in Neuralstems Favor in Dispute with StemCells, Inc.
7. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
8. Scientists synthesize memory in yeast cells
9. Breakthrough research identifies how cells from pigs may cure diabetes
10. Patent on Technology for the Delivery of Stem Cells to the Human Heart Issued to CellCyte Genetics Corp. of Washington
11. STEM CELLS Journal Names Co-Editors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Assembling cells into artificial 3-D microtissues, including a tiny gland
(Date:11/26/2014)... , Nov. 26, 2014 The announced sales ... the company is looking to expand in non-healthcare areas, ... The healthcare market research firm says that  Siemens is ... Information,s biennial survey of the IVD market , with ... change in its composition would likely affect IVD market ...
(Date:11/26/2014)... PMG Research, Inc. announced today the ... network of sites that provide clinical research services to pharmaceutical ... lives through its partnerships with large physician practices and integrated ... locations in the Southeastern United States and spans over 60 ... board will be held by: Dr. Robert Holmes, MD, ...
(Date:11/26/2014)... The Pittcon marketing department is pleased to ... mobile app, Pittcon 2015 . ... Store for iOS and Android devices and the Kindle ... and after the event. It acts as an all-inclusive ... sessions, Conferee Networking sessions and short courses. , The ...
(Date:11/26/2014)... 26, 2014 2014 Deep Research ... in-depth research report on the Global Palmitic Acid ... Palmitic Acid, basic information, including definition, classification, application, ... news analysis, etc. , For international and ... Acid market in China and other countries ...
Breaking Biology Technology:Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3Pittcon Releases 2015 Mobile App 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3
... CAMBRIDGE, Mass., April 17, 2012 Inspiration Biopharmaceuticals, Inc. ... Application (BLA) to the U.S. Food and Drug Administration ... factor IX (rFIX) protein for the treatment and prevention ... Based on the terms of its agreement with ...
... OLDSMAR, Fla., April 16, 2012  Cryo-Cell International, Inc. ... world,s first private cord blood bank to separate and ... the first quarter ended February 29, 2012.   ... many changes that are taking place at the Company," ...
... Md., April 16, 2012  The Maryland Technology Enterprise ... University of Maryland $75K Business Plan Competition ... has spurred the commercialization of university technologies and ... (Logo: http://photos.prnewswire.com/prnh/20101005/MTECHLOGO ) ...
Cached Biology Technology:Inspiration Biopharmaceuticals Announces Filing of Biologics License Application (BLA) for IB1001, a Recombinant Factor IX Product for People with Hemophilia B 2Inspiration Biopharmaceuticals Announces Filing of Biologics License Application (BLA) for IB1001, a Recombinant Factor IX Product for People with Hemophilia B 3Inspiration Biopharmaceuticals Announces Filing of Biologics License Application (BLA) for IB1001, a Recombinant Factor IX Product for People with Hemophilia B 4Cryo-Cell Reports Financial Results for First Quarter 2012 2Cryo-Cell Reports Financial Results for First Quarter 2012 3Cryo-Cell Reports Financial Results for First Quarter 2012 491 EnTERPreneurs Enter, Nine Remain 291 EnTERPreneurs Enter, Nine Remain 391 EnTERPreneurs Enter, Nine Remain 4
(Date:11/18/2014)... -- The Secure Identity & Biometrics Association (SIBA) and ... formation of The Airport Entry and Exit Working ... Biometric Entry and Exit Solutions Framework for Airports ... BORDERPOL, the international non-profit organization that works directly ... border security, traveler and migration systems. ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
(Date:11/11/2014)... Inc., a Chicago -based digital forensics ... of Yaniv Schiff from Senior Computer Forensics ... role as Director, he will lead company efforts to ... provide leadership within the company,s digital forensics practice area.  ... Schiff joined Forensicon in 2006 and has ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... National Park in northwest India, one thing was hard for biologist ... jackals. It was the squawks of peacocks in the throes of ... could hear a loud two-part whoop, the distinctive call that male ... a male announces that he,s ready to make his move by ...
... many different types of chemicals and plastics for the ... these materials are provided from petrochemical industry, using fossil ... concerns on the environmental problems and fossil resource availability, ... and materials from renewable non-food biomass through biorefineries. For ...
... Cancer Center study in this month,s edition of the ... potential treatment for melanoma, the most dangerous form of skin ... are expressed and which stay silent. Melanoma tends to lack ... a double negative," says Yiqun Shellman, PhD, investigator at the ...
Cached Biology News:Peacock love songs lure eavesdropping females from afar 2Production of 5-aminovaleric and glutaric acid by metabolically engineered microorganism 2Serendipity points to new potential target and therapy for melanoma 2