Navigation Links
Assembling cells into artificial 3-D microtissues, including a tiny gland
Date:3/5/2009

se specific DNA strands onto the cells, they used chemical reactions that do not interfere with cellular chemistry but nevertheless stick desired chemicals onto the cell surface. The technique for adding unusual but benign chemicals to cells was developed by Bertozzi more than a decade ago based on a chemical reaction called the Staudinger ligation.

After proving that they could assemble cells into microtissues, Gartner and Bertozzi constructed a minute gland analogous to a lymph node, for example such that one cell type secreted interleukin-3 and thereby kept a second cell type alive.

"What we did is build a little miniaturized, stripped-down system that operates on the same principle and looks like a miniaturized lymph node, an arrangement where two cells communicate with each another and one requires a signal from the other," she said. "The critical thing is that the two cells have to have a cell junction. If you just mix the cells randomly without connection, the system doesn't have the same properties."

She expects that eventually, clusters could be built on clusters to make artificial organs that someday may be implanted into humans.

"Our method allows the assembly of multicellular structures from the bottom up. In other words, we can control the neighbors of each individual cell in a mixed population," she said. "By this method, it may be possible to assemble tissues with more sophisticated properties."

One interesting aspect of the technique is that DNA hybridization seems to be temporary, like a suture. Eventually, the cells may substitute their own cell-cell adhesion molecules for the DNA, creating a well-knit and seemingly normal, biological system.


'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Self-assembling polymer arrays improve data storage potential
2. Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells
3. Reovirus Infection of Melanoma Cells Generates Anti-Tumour Immunity
4. Scientists synthesize memory in yeast cells
5. BioLife Solutions CryoStor(TM) Adopted by Tissue Regeneration Therapeutics for Preservation Protocol for New, Non-Embryonic Source of Stem Cells
6. Patent Office Rules in Neuralstems Favor in Dispute with StemCells, Inc.
7. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
8. Scientists synthesize memory in yeast cells
9. Breakthrough research identifies how cells from pigs may cure diabetes
10. Patent on Technology for the Delivery of Stem Cells to the Human Heart Issued to CellCyte Genetics Corp. of Washington
11. STEM CELLS Journal Names Co-Editors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Assembling cells into artificial 3-D microtissues, including a tiny gland
(Date:1/23/2015)... Biofertilizers stimulate microbial activities in soil. These microorganisms generate ... activities in the soil or in the rhizosphere. The ... on reducing environmental pollution and on reducing the usage ... the bio fertilizers market with analysis and forecasting of ...
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... January 22, 2015 Protocol Networks brings ... growing team of brand-neutral, independent consultants, Protocol Networks has ... explained that over the years, his company has attracted ... Town of Plainfield, as well as others. With the ...
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2
... with today,s invisibility cloaks, people can,t walk through walls. ... The electrons perform this trick, called macroscopic quantum tunneling, ... of space that is normally off-limits under the laws ... of electrons collectively move through a superconducting nanowire, they ...
... Scientists from the Georgia Institute of Technology have ... "confinement controlled sublimation" technique for growing high-quality layers ... technique relies on controlling the vapor pressure of ... fabricating the material. The basic principle for ...
... 2011 MaxWest Environmental Systems, Inc. ... wastewater treatment industry, was recognized on stage yesterday at ... Meeting in New York City for its Commitment to ... selected as an exemplary approach to addressing challenges in ...
Cached Biology Technology:Scientists observe how superconducting nanowires lose resistance-free state 2Scientists observe how superconducting nanowires lose resistance-free state 3Controlling silicon evaporation allows scientists to boost graphene quality 2Controlling silicon evaporation allows scientists to boost graphene quality 3MaxWest Environmental Systems Makes Commitment to Clinton Global Initiative 2MaxWest Environmental Systems Makes Commitment to Clinton Global Initiative 3
(Date:1/22/2015)...  Analyst Report Issued by Small Cap IR. In 2011, Nilson ... transactions at merchants on the leading payment cards rose to ... debit, and prepaid cards reached 6.54 billion.  Eight million credit ... usage in 2012, and credit and debit card fraud resulted ...
(Date:1/22/2015)... Infinisource has launched its new NXG series of time clocks ... a higher standard for collecting attendance and labor data and ... installation, touch screen interface and seamless connection to cloud-based iSolved, ... solution for the small to mid-size employer. The ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season may ... Acuity Market Intelligence reports that the long anticipated floodgates ... that intensifying demand for smart phones, tablets, and wearable ... market of 2.5 billion users with nearly 4.8 billion ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Infinisource's NXG series sets new time clock standard 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... developed a computer modeling method to accurately predict how ... the complex work from an inhibitory weeks-long process to ... efficient evaluation of a nerve,s response to millions of ... accurate and capable electrodes to stimulate nerves and thereby ...
... MD, a clinician and scientific investigator in the Division ... Beth Israel Deaconess Medical Center (BIDMC) has been selected ... the Doris Duke Charitable Foundation. The three-year award, which ... and environmental factors that lead to kidney disease in ...
... its first appearance in Texas, a prehistoric crocodile thought to ... native of the Lone Star State. The switch in ... the identification of a well-preserved, narrow fossil snout that was ... The 96-million-year-old fossil from Texas is the oldest prehistoric crocodile ...
Cached Biology News:Fast prediction of axon behavior 2BIDMC scientist David J. Friedman, M.D., receives award from Doris Duke Charitable Foundation 296-million-year-old fossil suggests prehistoric crocodile Terminonaris was Texas native 296-million-year-old fossil suggests prehistoric crocodile Terminonaris was Texas native 396-million-year-old fossil suggests prehistoric crocodile Terminonaris was Texas native 4
... an aqueous-based mounting medium designed for ... Gel/Mount is especially recommended when using ... FluoroBlue. It can also be used ... fluorescein (FITC), Rhodamine (TMRITC) and Texas ...
... specifically formulated for mounting tissue specimens, cell ... with immunohistochemical methods for viewing by light ... chromogens, such as AEC, that are alcohol-soluble ... completely when slides are cover-slipped forming a ...
...
...
Biology Products: