Navigation Links
Assembling cells into artificial 3-D microtissues, including a tiny gland
Date:3/5/2009

Berkeley -- As synthetic biologists cram more and more genes into microbes to make genetically engineered organisms produce ever more complex drugs and chemicals, two University of California chemists have gone a step further.

They have assembled different types of genetically engineered cells into synthetic microtissues that can perform functions such as secreting and responding to hormones, promising more complex biological capabilities than a single cell alone could produce.

"This is like another level of hierarchical complexity for synthetic biology," said coauthor Carolyn Bertozzi, UC Berkeley professor of chemistry and of molecular and cell biology and director of the Molecular Foundry at Lawrence Berkeley National Laboratory. "People used to think of the cell as the fundamental unit. But the truth is that there are collections of cells that can do things that no individual cell could ever be programmed to do. We are trying to achieve the properties of organs now, though not yet organisms."

While the synthetic tissues today comprise only a handful of cells, they could eventually be scaled up to make artificial organs that could help scientists understand the interactions among cells in the body and might some day substitute for human organs.

"We are really taking this into the third dimension now, which for me is particularly exciting," said first author Zev J. Gartner, a former UC Berkeley post-doctoral fellow who recently joined the UC San Francisco faculty as an assistant professor of pharmaceutical chemistry. "We are not simply linking cells together, we are linking them together in 3-D arrangements, which introduces a whole new level of cellular behavior which you would never see in 2-D environments."

Gartner and Bertozzi, the T.Z. and Irmgard Chu Distinguished Professor at UC Berkeley and a Howard Hughes Medical Institute investigator, report on their assembly of three-dimensional microtissues this week i
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Self-assembling polymer arrays improve data storage potential
2. Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells
3. Reovirus Infection of Melanoma Cells Generates Anti-Tumour Immunity
4. Scientists synthesize memory in yeast cells
5. BioLife Solutions CryoStor(TM) Adopted by Tissue Regeneration Therapeutics for Preservation Protocol for New, Non-Embryonic Source of Stem Cells
6. Patent Office Rules in Neuralstems Favor in Dispute with StemCells, Inc.
7. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
8. Scientists synthesize memory in yeast cells
9. Breakthrough research identifies how cells from pigs may cure diabetes
10. Patent on Technology for the Delivery of Stem Cells to the Human Heart Issued to CellCyte Genetics Corp. of Washington
11. STEM CELLS Journal Names Co-Editors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Assembling cells into artificial 3-D microtissues, including a tiny gland
(Date:11/22/2014)... 22, 2014 Respiratory therapy students ... proper management of life-like respiratory ailments using the ... . Grand Rapids-based, Michigan Instruments Inc. developers of ... of the respiratory simulation units to the pro-gram, ... Valley and Muskegon Community College are collaborating to ...
(Date:11/21/2014)...   TRU-D SmartUVC LLC and its UK partners, ... disinfection robot, TRU-D SmartUVC, at FIS 2014 in ... 26 at Stand 23. The conference, hosted by ... largest infection-related event of its kind and brings ... the leading events of its type throughout the world. This ...
(Date:11/21/2014)... 20, 2014 The California ... research organization representing leading California academic institutions, biotechnology, ... PwC US today released a report revealing ... industry growth. The trend shows a 4 percent ... California Biomedical Industry Report indicates that, while ...
(Date:11/21/2014)... 21, 2014 Why did Stephen Hawking ... Einstein so instantly recognizable? Why have they become icons ... and author Hilton Ratcliffe seeks out the answers to ... all to do with science. In " Stephen Hawking ... November 21, 2014), Ratcliffe puts it plainly: , ...
Breaking Biology Technology:Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... (CT) and Magnetic Resonance Imaging (MRI) to investigate internal ... Images revealed, for the first time non-invasively, how a ... big meal and during digestion, until it has disappeared ... of animal anatomy could be valuable supplements to traditional ...
... 29 The California Department of Labor today awarded ... grant to implement new workforce training programs for careers ... a collaborative effort including CleanTECH San Diego, BIOCOM, San Diego ... the San Diego Workforce Partnership, captured the grant through the ...
... June 29 Genomatica announced today ... of schedule. First, the company achieved pilot-scale validation, at ... a ,green, version of 1,4-butanediol (BDO), its first commercial ... time and reduced development and production costs made possible ...
Cached Biology Technology:Feast and famine: MRI reveals secrets of animal anatomy 2San Diego Region Awarded $4 Million Workforce Development Grant to Support Expanding Biofuels Industry 2San Diego Region Awarded $4 Million Workforce Development Grant to Support Expanding Biofuels Industry 3San Diego Region Awarded $4 Million Workforce Development Grant to Support Expanding Biofuels Industry 4Genomatica Delivers Pilot-Scale Validation in Sustainable Chemical Manufacturing 2Genomatica Delivers Pilot-Scale Validation in Sustainable Chemical Manufacturing 3Genomatica Delivers Pilot-Scale Validation in Sustainable Chemical Manufacturing 4
(Date:11/4/2014)... amount of death at the right time might actually ... research that could help in understanding animal populations, pest ... a paper in the journal Trends in Ecology ... colleagues conclude that the kind of positive population effect ... or mortality, depends on the size and developmental stage ...
(Date:11/4/2014)... , November 4, 2014   ... market growth   Fuel3D , a developer ... a funding round totaling $6.4 million (£4 million). This funding ... secured earlier this year and paves the way for the ... The funding round was led by Chimera Partners ...
(Date:11/3/2014)... of Colorado Cancer Center study published in ... Sciences describes the activity of a recently discovered ... or IL-37. It has been known to limit inflammation ... adaptive immune system: IL-37 inhibits the ability of the ... "Knowing this mechanism that underlies IL-37,s effect on the ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
... to maximise their chances of producing offspring across a ... the evolution of ejaculation strategies. The findings by researchers ... Oxford suggest that, paradoxically, matings with attractive males may ... In the paper, published in the journal ...
... Researchers from the Centers for Disease Control and Prevention ... is influenced by age of menarche and total number ... hormonal activity over the course of a woman,s lifetime ... Results of this study are published in Cancer ...
... manners to wait your turn it,s actually down to ... A study in the University,s School of Psychology sought ... species. The conclusion is that there is an "invisible hand" ... Colman and Dr Lindsay Browning carried out the study due ...
Cached Biology News:Spread your sperm the smart way 2Spread your sperm the smart way 32 reproductive factors are important predictors of death from ovarian cancer 22 reproductive factors are important predictors of death from ovarian cancer 3Research shows that 'invisible hand' guides evolution of cooperative turn-taking 2
Mouse monoclonal [1.F.1] to Yersinia pestis F1 antigen ( Abpromise for all tested applications). Antigen: Purified F1 antigen of Y. pestis vaccine strain EB....
Rabbit polyclonal to L Kynurenine ( Abpromise for all tested applications). Antigen: Synthetic peptide L Kynurenine conjugated to a protein carrier. Entrez Gene ID: 8942 Swiss Protein ID...
Rabbit polyclonal to P5 ( Abpromise for all tested applications). entrezGeneID: 10954 SwissProtID: Q14554...
anti-achaete...
Biology Products: