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Argos Therapeutics Presents Data Showing Memory T Cell Expansion After Administration of Fully Personalized Immunotherapy Correlates with Overall Survival Benefit in Patients with Metastatic Renal Cell Carcinoma
Date:11/11/2013

DURHAM, N.C., Nov. 11, 2013 /PRNewswire/ -- Argos Therapeutics Inc., a biopharmaceutical company focused on the development and commercialization of fully personalized immunotherapies for the treatment of cancer and infectious diseases using its Arcelis™ technology platform, presented an analysis of data from its Phase 2 clinical trial showing that treatment with AGS-003, the company's lead product candidate, in combination with sunitinib, induced memory T cell responses in metastatic renal cell cancer (mRCC) patients that correlated with statistical significance to overall survival (OS).  The poster, entitled "Multi-Functional Cytotoxic T Cell Expansion Correlates with Overall Survival after Administration of Autologus Dendritic Cell Immunotherapy in Renal Cell Cancer Patients," was presented on November 9 at the 28th Annual Meeting of the Society for Immunotherapy of Cancer in National Harbor, Maryland.

AGS-003, an investigational fully personalized immunotherapy, is designed to elicit an immune response by inducing CD8+CD28+ memory T cells that are known to correlate with improved clinical outcomes. In the Phase 2 trial, the Company monitored the immune responses in 14 evaluable intermediate and poor risk mRCC patients using multi-color flow cytometry. The data were analyzed for correlations between immune responses and survival using an adaptation of the bioinformatics pattern recognition algorithm, Binary Tree-Structured Vector Quantization (BTSVQ). Patients in the trial received treatment in standard six-week cycles of sunitinib plus AGS-003 every three weeks for five doses and then every 12 weeks until progression.  BTSVQ identified unique cytotoxic T cell (CTL) signatures displaying broad markers of immune function (MIFs) that were statistically significant predictors of survival duration as well as mono-functional late-stage effector T cells that inversely correla
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