Navigation Links
Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine)
Date:2/25/2008

their choice of therapy for treating acute agitation. We believe that many patients with schizophrenia or bipolar disorder disease can make informed decisions regarding their treatment in an acute agitative state and would prefer a rapid-acting, noninvasive treatment.

We believe there is a significant unmet medical need for an acute agitation treatment option that will provide a fast onset of effect, that is noninvasive and safer to administer, and that allows patients to be active participants in choosing acceptable treatment options for themselves.

About AZ-004 (Staccato loxapine)

AZ-004 is the combination of Alexza's proprietary Staccato system with loxapine, a drug belonging to the class of compounds known generally as atypical antipsychotics. The Staccato system technology is a hand-held, chemically-heated, single dose inhaler designed to generate and deliver excipient-free drug aerosol for deep lung delivery that results in IV-like pharmacokinetics. Alexza has completed three clinical trials with AZ-004, including a 50 subject Phase 1 study, a 129 patient Phase 2 study and a 32 patient multiple-dose tolerability and PK study in schizophrenic patients.

The Company believes that the unique delivery of loxapine via the Staccato system will provide rapid onset of drug effect, as measured by a reduction in the signs and symptoms of acute agitation. In March 2007, Alexza announced positive initial results from a multi-center, randomized, double-blind, placebo-controlled Phase 2 clinical trial in 129 patients in an in-patient clinical setting. The 10 mg dose of AZ-004 met the primary endpoint of the clinical trial, which was a statistically significant reduction in the measure of agitation from baseline to the 2-hour post-dose time point, as compared to placebo. The 10 mg dose of AZ-004 also exhibited a rapid onset of effect, with a statistically significant improvement in the PANSS (Positive and Negative Symptom Scale) Excited Component (
'/>"/>

SOURCE Alexza Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. The 4th Annual BIO Investor Forum to Webcast Alexzas Corporate Presentation
2. 19th Annual Piper Jaffray Health Care Conference to Webcast Alexzas Corporate Presentation
3. Alexza Elects Dr. Hal V. Barron to Its Board of Directors
4. Alexza Announces Partnership With Endo for AZ-003 (Staccato(R) fentanyl) in North America
5. Merrill Lynch Global Pharmaceutical, Biotechnology & Medical Device Conference to Webcast Alexzas Corporate Presentation
6. Alexzas Corporate Presentation to be Webcast at the 10th Annual BIO CEO & Investor Conference
7. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
8. Dawson James Securities Initiates Research Coverage on CryoCor, Inc. (Nasdaq: CRYO) with a Strong Buy Rating and $6.00 Target Price
9. Spectrum Pharmaceuticals Initiates Second Registrational Phase 3 Clinical Trial for EOquin(R) in Patients With Non-Invasive Bladder Cancer
10. XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain
11. Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... The report “Fragrance Ingredients Market by ... & Toiletries, and Soaps & Detergents) & by Geography ... and segmented the Fragrance Ingredients Market with analyses and ... value. The market has been segmented on the basis ... Latin America, and Rest of the World (ROW); and ...
(Date:10/30/2014)... 30, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Naltrexone HCL information, including its definition, classification, application, ... overview. This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic situation ...
(Date:10/30/2014)... 2014 James Sherley says he has been ... stem cell technology since his days as a principal investigator ... the late 1990’s. Sherley founded the ASCTC as a ... all the intellectual property developed in Sherley’s research over the ... Institute of Technology (MIT), and more recently as a senior ...
(Date:10/30/2014)... Khaimah, UAE (PRWEB) October 30, 2014 Grace ... of Dr. James A. Manganello, Chairman of the Board, to ... The Bahamas. The appointment was made by the Ministry ... on September 24th, 2014. , More than a ... and Research Bill , Prime Minister Perry Christie said the ...
Breaking Biology Technology:Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
... ... of the National Institutes of Health (NIH), awarded a $2.18 million grant to Aciont Inc. ... , ... City, UT (PRWEB) December 10, 2009 -- The National Eye Institute (NEI), a division of ...
... , , ... TAI,AN, China, Dec. 10 /PRNewswire-Asia-FirstCall/ -- China Biologic,Products, Inc. (Nasdaq: ... biopharmaceutical companies in China, today announced,that the Company,s senior management team ... City at 9:30 a.m. ET on Tuesday, December 15,2009. , ...
... SEATTLE, Dec. 10 Dendreon Corporation (Nasdaq: DNDN ) ... chief operating officer, effective January 4, 2010. Mr. Bishop ... at Bayer, where he was responsible for a diverse portfolio ... served as an executive vice president of Bayer HealthCare LLC. ...
Cached Biology Technology:NEI Awards a Two-Year $2.18 Million SBIR Grant to Aciont 2NEI Awards a Two-Year $2.18 Million SBIR Grant to Aciont 3China Biologic Products to Ring NASDAQ Opening Bell 2China Biologic Products to Ring NASDAQ Opening Bell 3Dendreon Appoints Hans Bishop as Chief Operating Officer 2
(Date:10/31/2014)... the world,s largest producer of cocoa. Chocolate trees ( ... ha region of rainforest in the state of Bahia, ... the surrounding rainforest was a biodiversity hotspot, the chocolate ... seeds introduced in the mid 1700s, had very low ... Pereira, "This scenario created a very romantic, but extremely ...
(Date:10/31/2014)... the air out of a nagging mystery about the development ... as to why animal species didn,t flourish sooner, once sufficient ... the end of the Proterozoic period, about 800 million years ... when most researchers think there also was plenty of oxygen? ... after all. , In a study published Oct. 30 in ...
(Date:10/31/2014)... the war against Ebola one important hurdle has just ... at the University of North Carolina at Chapel Hill ... mice that can be infected with Ebola and display ... published in the current issue of Science , ... vaccines, which are desperately needed to curb the worldwide ...
Breaking Biology News(10 mins):Scientists seek cure for devastating witches' broom disease of the chocolate tree 2Scientists seek cure for devastating witches' broom disease of the chocolate tree 3Lack of oxygen delayed the rise of animals on Earth 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2
... a nanomedicine milestone today as they announced the creation ... forms a partnership between university researchers and an international ... treatment created at MU. Shasun Pharmaceuticals Ltd., one ... new company in partnership with MU nanomedicine experts Kattesh ...
... international effort, on the scale of the Human Genome ... cancer cells. HGP was the international scientific research project ... Within a decade, they believe, results of the new ... customized to their own biology. The perspective appears in ...
... sharks may be too weak to capture and kill large marine ... Biomechanics by an international team of scientists. , The researchers also ... matter how widely their jaws are open, thanks to a unique ... most successful predators of all time. , The study is the ...
Cached Biology News:MU cancer scientists form new company with international pharmaceutical firm 2MU cancer scientists form new company with international pharmaceutical firm 3Teenage great white sharks are awkward biters 2
... Fiberboard boxes are ideal for use in refrigerators, freezers, ... racks. Four vibrant colors allow for color coding to ... liquid nitrogen drainage or promote cool air circulation. Supplied ... holds 81 tubes. Box dimensions: 13 x ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
RABBIT ANTI AMPHOTERIN...
Biology Products: