Navigation Links
Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
Date:10/15/2007

AMSTERDAM, October 15 /PRNewswire/ -- Agendia BV, world leader in the rapidly evolving field of molecular diagnostics, announced today that it has acquired the rights to the discovery of a major mechanism of resistance to the frequently-used breast cancer drug Herceptin(R), which is published in the October 15 issue of the journal "Cancer Cell".

The antibody drug Herceptin(R) targets the HER2 protein, which is hyper-active in about one in four breast cancers and the HER2 protein contributes to aggressive cancer behavior. Striking initial responses are observed in combination with chemotherapy in more than half of treated patients. However, the majority of responding patients eventually develop resistance to Herceptin-based therapies. The laboratory of Agendia's Chief Scientific Officer, Prof. Rene Bernards, today published a rapid method to identify biomarkers associated with non-responsiveness to cancer drugs in cell culture and used the technology to identify a mechanism of resistance to Herceptin-based cancer therapy. His work also demonstrated that these biomarkers indeed have predictive value in patients treated with this drug, thus validating the approach.

"The availability of biomarkers that predict responses to cancer therapy is instrumental to the rational use of cancer drugs in the clinic. Elucidating the molecular mechanism of drug resistance can be critical to identify patients that fail to respond to therapy and may help design more efficient treatment protocols", says Rene Bernards. "Although more work is needed to further validate our findings, the method is generally applicable to find mechanisms of drug resistance and should expedite the development of biomarkers that are associated with therapy non-responsiveness".

The technology used relies on the simultaneous inactivation of thousands of genes through a process known as RNA interference in cells that are sensitive to a specific cancer drug. If the inactivation of a specif
'/>"/>

SOURCE Agendia BV
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Fiserv acquires crime management software firm
2. GenTel acquires GlaxoSmithKline chip platform
3. Tushaus Computer acquires managed service business
4. RedPrairie acquires Denver software company
5. Eagle Technology acquires some synergy
6. Brady Corp. acquires Korean counterpart
7. Canadian firm acquires Silicon Logic
8. Imago acquires synergistic British firm
9. Fiserv acquires insurance, training product lines
10. Amazon acquires Madison-based Shopbop
11. Metavante acquires health-care payments firm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 2015  Sonoa Health, a health tech startup based ... a world-first consumer health portal, Health&, which brings together ... and more. Today, the Company appointed respected ... who brings to the table more than 18-years experience ... working closely with the biggest names in Silicon Valley ...
(Date:3/31/2015)... NEW YORK , March 31, 2015 /PRNewswire/ ... biopharmaceutical company advancing protein biologic therapies and oncology ... marketing partner, Hanmi Pharmaceutical Co., Ltd ("Hanmi") (KSE: ... the country,s Ministry of Food and Drug Safety ... (KTR) for MuGard, its oncology supportive-care treatment for ...
(Date:3/31/2015)... Diasome Pharmaceuticals, Inc. ( http://www.diasome.com ) ... a United States patent has recently been allowed for ... , Entitled “Lipid Construct for Delivery of Insulin to ... related to the use of Diasome’s proprietary Hepatocyte Directed ... to more effectively reach the liver’s metabolic cells, called ...
(Date:3/30/2015)... March 30, 2015  Multiple new research abstracts suggest ... important health factors. From their impact on colon cancer ... effect on both gut health and vascular health, the ... our latest understanding of walnuts, inner workings. Running March ... , this annual meeting attracts an international audience of ...
Breaking Biology Technology:Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 2PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 3Diasome Pharmaceuticals, Inc. Announces Notice of Allowance from US PTO for Liver Targeting System for Insulin 2New Findings Support the Benefits of Eating Walnuts on Overall Health 2New Findings Support the Benefits of Eating Walnuts on Overall Health 3New Findings Support the Benefits of Eating Walnuts on Overall Health 4
... telescopes or optoelectronic communications, infrared detectors must be ... thermal radiation. Now, a team of researchers from ... Duke University (USA) is harnessing the remarkable properties ... sensitive, "uncooled" photovoltaic infrared detectors. This ...
... 2012 Reportlinker.com announces that a new ... catalogue: Nanotechnology for ... http://www.reportlinker.com/p0799333/Nanotechnology-for-Drug-Delivery-Global-Market-for-Nanocrystals.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology Nanocrystals ... billion nanotechnology-enabled drug delivery market by 2021. ...
... press release is available in German and French ... bring to an end to the confusing mishmash of jargon which ... Harald Krug,s assessment of the situation. Krug is a member of ... past few years the number of publications on nanotoxicology has increased ...
Cached Biology Technology:Sensing the infrared: Researchers improve IR detectors with single-walled carbon nanotubes 2Sensing the infrared: Researchers improve IR detectors with single-walled carbon nanotubes 3Nanotechnology for Drug Delivery: Global Market for Nanocrystals 2Nanotechnology for Drug Delivery: Global Market for Nanocrystals 3Nanotechnology for Drug Delivery: Global Market for Nanocrystals 4Nanotechnology for Drug Delivery: Global Market for Nanocrystals 5Nanotechnology for Drug Delivery: Global Market for Nanocrystals 6Nanotechnology for Drug Delivery: Global Market for Nanocrystals 7Nanotechnology for Drug Delivery: Global Market for Nanocrystals 8Nanotechnology for Drug Delivery: Global Market for Nanocrystals 9A milestone in nanoparticle research: Nanoparticle test handbook sets the standards 2
(Date:3/23/2015)... -- In the 2014 fiscal year, irs.gov recorded over $100 ... accounts for a fraction of the estimated losses for ... $11 billion globally. The polygraph has traditionally been used ... Investor Mark Saint Juste along with former ... partnered to administer the test in a new way: ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... America . Annual estimates and forecasts are ...
(Date:3/17/2015)... 2015  MecklerMedia Corporation (OTCQX: MECK) announced its ... robots ever held in New York ... 11-13, 2015 at the Javits Convention Center. ... include: Acorn Product Development; Axis NJ; c-Link Systems; ... Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2
... climate are altering growing conditions in temperate rain forests, ... according to research conducted by the U.S. Forest Service,s ... the January 2013 issue of Science Findings a ... forest plant responses to a warming climate. "Although ...
... performed by trained nurse practitioners, physician assistants and certified nurse ... six-year study led by UCSF. The study posted online ... in advance of the print edition. The publication comes ... Wade, the landmark Supreme Court decision that made abortion legal ...
... dividing cell, but there,s a catch. You are looking at ... but it,s not a cell, because there,s no cell membrane. ... Ivo Telley from the European Molecular Biology Laboratory (EMBL) in ... embryo, at a stage when it is essentially a sac ...
Cached Biology News:Climate change's effects on temperate rain forests surprisingly complex 2Abortions are safe when performed by advanced practice nurses and physician assistants, study shows 2Abortions are safe when performed by advanced practice nurses and physician assistants, study shows 3
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
... seals labware. Waterproof, moisture-proof film prevents ... Can be folded repeatedly and twisted ... lengthwise at 21C (70F), wrapping film ... is removed, film only partially returns ...
PlusOne EDTA, disodium salt, 100 g. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Buffers....
...
Biology Products: