Navigation Links
Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
Date:10/15/2007

AMSTERDAM, October 15 /PRNewswire/ -- Agendia BV, world leader in the rapidly evolving field of molecular diagnostics, announced today that it has acquired the rights to the discovery of a major mechanism of resistance to the frequently-used breast cancer drug Herceptin(R), which is published in the October 15 issue of the journal "Cancer Cell".

The antibody drug Herceptin(R) targets the HER2 protein, which is hyper-active in about one in four breast cancers and the HER2 protein contributes to aggressive cancer behavior. Striking initial responses are observed in combination with chemotherapy in more than half of treated patients. However, the majority of responding patients eventually develop resistance to Herceptin-based therapies. The laboratory of Agendia's Chief Scientific Officer, Prof. Rene Bernards, today published a rapid method to identify biomarkers associated with non-responsiveness to cancer drugs in cell culture and used the technology to identify a mechanism of resistance to Herceptin-based cancer therapy. His work also demonstrated that these biomarkers indeed have predictive value in patients treated with this drug, thus validating the approach.

"The availability of biomarkers that predict responses to cancer therapy is instrumental to the rational use of cancer drugs in the clinic. Elucidating the molecular mechanism of drug resistance can be critical to identify patients that fail to respond to therapy and may help design more efficient treatment protocols", says Rene Bernards. "Although more work is needed to further validate our findings, the method is generally applicable to find mechanisms of drug resistance and should expedite the development of biomarkers that are associated with therapy non-responsiveness".

The technology used relies on the simultaneous inactivation of thousands of genes through a process known as RNA interference in cells that are sensitive to a specific cancer drug. If the inactivation of a specif
'/>"/>

SOURCE Agendia BV
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Fiserv acquires crime management software firm
2. GenTel acquires GlaxoSmithKline chip platform
3. Tushaus Computer acquires managed service business
4. RedPrairie acquires Denver software company
5. Eagle Technology acquires some synergy
6. Brady Corp. acquires Korean counterpart
7. Canadian firm acquires Silicon Logic
8. Imago acquires synergistic British firm
9. Fiserv acquires insurance, training product lines
10. Amazon acquires Madison-based Shopbop
11. Metavante acquires health-care payments firm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... BANGALORE, India , July 1, 2015 /PRNewswire/ ... uses next generation sequencing technology to empower cancer care, ... as chief executive officer. In his expanded role ... for all strategy, business expansion and worldwide operations effective ... as Strand,s chairman and CEO since its founding in ...
(Date:7/1/2015)... InferMed , s ... will augment ... s olutions suite   Elsevier , ... and services, announced today the acquisition of  InferMed , a ... company. InferMed,s Arezzo technology supports clinicians in choosing ...
(Date:6/30/2015)... ... June 30, 2015 , ... Students and ... in the first half of “Integrative Biotechnology,” an applied biotechnology course team-taught by ... 2014, this course combines students from both universities and is taught on both ...
(Date:6/30/2015)... June 30, 2015  Today, Americord Registry, one of the ... Andrew Horne , a partner at Kirkland & Ellis LLP, ... Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We are ... Board," says Martin Smithmyer , CEO of Americord. "He ... career that will assist Americord,s growth and vision." ...
Breaking Biology Technology:Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2Americord Registry Announces Andrew Horne as Advisory Board Member 2
... Cellumen, Inc. and Mayo Foundation,for Medical Education and ... apply cellular systems biology (CSB(TM)) profiling to,breast cancer ... breast cancer,patient profile test to improve diagnosis and ... to initiate an exciting research and development,program with ...
... a leading,provider of immunoassay kits, antibodies, and reagents to the ... its,senior leadership team: - Michael Mullenix, PhD, has ... Research and Development. Dr. Mullenix comes to Assay Designs from ... he was a Principal Scientist in their ...
... LOUIS, Oct. 1 ISTO Technologies, Inc., ... the United States Patent,Office granted a key ... cartilage repair: "Method for Chondrocyte Expansion with,Phenotype ... for cartilage regeneration and,repair in knee joints ...
Cached Biology Technology:Assay Designs(TM) Announces Additions to the Leadership Team 2ISTO Technologies Granted Key Patent for Cartilage Cell Expansion by the United States Patent Office 2
(Date:7/2/2015)... 25, 2015 Research and ... "Next Generation Biometrics Market by Application, Technology, Function ... to their offering. The next generation biometrics ... at a CAGR of 17.9% between 2015 and 2020 ... for the market. Safran SA ( ...
(Date:6/26/2015)... , June 26, 2015 ATL Technology, LLC, a ... with specialties in single use solutions, headquartered in ... Inc. (a California corporation with locations ... San Jose, Costa Rica ). This ... Rica with ATL Technology,s existing facility in ...
(Date:6/24/2015)... NEW YORK , June 24, 2015 ... Systems market, over the next six years. It contains ... affect the industry, along with their impact from the ... It also discusses the industry, market, and technology ... expected that the need of concerned authorities to efficiently ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... UC San Diego returning from research expeditions in ... life and ecosystems in the Gulf of California, ... previously never seen alive. Yet the expeditions, which ... declines in sea-life populations and evidence that human ...
... corrective gene into mouse blood cells, scientists at St. ... pathology. In their studies, the researchers found that the ... Although the scientists caution that applying the gene therapy ... the new therapy will become an important treatment for ...
... A recent ESA campaign has demonstrated how a technique ... in the atmosphere. The campaign supports one of the ... A-SCOPE (Advanced Space Carbon and climate Observation of ... Explorer missions that has just completed assessment study. The ...
Cached Biology News:Expeditions reveal gulf of California's deep sea secrets, as well as human imprints 2Expeditions reveal gulf of California's deep sea secrets, as well as human imprints 3Expeditions reveal gulf of California's deep sea secrets, as well as human imprints 4Gene therapy corrects sickle cell disease in laboratory study 2Gene therapy corrects sickle cell disease in laboratory study 3ESA tests laser to measure atmospheric carbon dioxide 2ESA tests laser to measure atmospheric carbon dioxide 3
... Kit, For 100 slides. Immunocytochemistry.Sample types: ... vitro tissue labeling.Recommended cell number: ... 1-2 hours).Store at 2-8 C (except ... Drug Screening & Cellular Assays, Assays ...
... Ideal for isolation and affinity purification ... and peptides. Hydrophobic, monodisperse magnetic particles ... (tosyl) groups, further surface activation is ... antibodies with optimal orientation for affinity ...
... Anti-phospho-Ser/Thr-Pro, MPM-2, agarose conjugate ... sodium azide Quality ... immunoprecipitating mitotic MPM2 antigens ... HeLa cells as shown ...
Calcium Channel alpha 2 delta-2 Purified Anti-Mouse, Anti-Rat, Anti-Human clone 42, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
Biology Products: