Navigation Links
Adult cells transformed into early-stage nerve cells, bypassing the pluripotent stem cell stage
Date:5/2/2013

MADISON, Wis. A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells without passing through the do-it-all stage called the induced pluripotent stem cell, or iPSC.

Bypassing the ultra-flexible iPSC stage was a key advantage, says senior author Su-Chun Zhang, a professor of neuroscience and neurology. "IPSC cells can generate any cell type, which could be a problem for cell-based therapy to repair damage due to disease or injury in the nervous system."

In particular, the absence of iPSC cells rules out the formation of tumors by pluripotent cells in the recipient, a major concern involving stem cell therapy.

A second advance comes from the virus that delivers genes to reprogram the adult skin cells into a different and more flexible form. Unlike other viruses used for this process, the Sendai virus does not become part of the cell's genes.

Jianfeng Lu, Zhang's postdoctoral research associate at the UWMadison Waisman Center, removed skin cells from monkeys and people, and exposed them to Sendai virus for 24 hours. Lu then warmed the culture dish to kill the virus without harming the transforming cells. Thirteen days later, Lu was able to harvest a stem cell called an induced neural progenitor. After the progenitor was implanted into newborn mice, neural cells seemed to grow normally, without forming obvious defects or tumors, Zhang says.

Other researchers have bypassed the pluripotent stem cell stage while turning skin cells into neurons and other specialized cells, Zhang acknowledges, but the new research, just published in Cell Reports, had a different goal. "Our idea was to turn skin cells to neural progenitors, cells that can produce cells relating to the neural tissue. These progenitors can be propagated in large numbers."

The research overcomes limitations of previous efforts, Zhang sa
'/>"/>

Contact: Su-Chun Zhang
szhang4@wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Adult Acne Treatment, Probiotic Action Introduces their Antibiotic-Free Acne Treatment
2. Stem Cell Institute Public Seminar on Adult Stem Cell Therapy in Miami, Florida May 11th, 2013
3. Probiotic Action Announces Their Skin Care Treatment for Men Suffering from Adult Acne
4. Probiotic Action Shares New Insight on Why Adult Acne May Affect Women More than Men
5. Preliminary Research, Led By Dr. Vincent Giampapa, Finds Aged Adult Stem Cells Can Be Functionally Reprogrammed To Act Like Younger Cells
6. Probiotic Action Announces New Use for Their Adult Acne Treatment and Explains its Beauty Benefits for Women
7. More Than 100 Groups Support ABC-AHP-NCNPR Botanical Adulterants Program
8. Island Abbey Foods™ Honibe® Honey Delights® Now Available as Nature’s Tastiest Suckers™ for Kids and Adults
9. Island Abbey Foods Ltd™ Now Offering New Honibe® Honey Lozenges™ Flavour Variations for Both Adults and Children
10. Adult Stem Cell Therapy Breakthrough Leads to Crowd Funding Campaign on Indiegogo.com for Centagen, Inc.
11. Thackray Crane Rental Prepares Visible Memorial For The Newtown, Connecticut Children and Adults Who Were Ambushed and Taken Away From Their Families
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... 2014 Cynvenio, a cancer diagnostics company ... genomic analysis of tumor cells in the bloodstream, today ... cancer decision support application powered by CollabRx, Inc. ... genomic test, Therapy Finder will provide breast cancer patients ...
(Date:1/15/2014)... 15, 2014 A study has been launched ... Formula 1 track could help to tackle the problem of ... Stowhealth (a GP surgery based in Stowmarket) and academics at ... Telemetry technology, which is inspired by equipment used ...
(Date:1/15/2014)... 15, 2014 DTS Language Services, Inc ... Web Portal for Life Science organizations who need document translations. ... subject matter of their documents in advance with a selection ... time-to-delivery of translations, often a critical factor in clinical and ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... proven cost-effective, Genomatica looks to develop demonstration plant ... Genomatica, a sustainable chemicals company, announced today that ... milestone toward the production of commercial grade 1,4-butanediol ... The company has demonstrated that it can ...
... Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, ... today announced that it will host a webcast on June 8, ... 6th at the 14th Congress of the European Hematology Association. ... www.micromet-inc.com . , , Forum: ...
... Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ... vice president, corporate development and chief financial officer. Mr. ... biotechnology and pharmaceutical industry in corporate finance, corporate and business ... , Prior to joining Lexicon, Mr. Bansal was chief financial ...
Cached Biology Technology:Genomatica Produces Pure BDO From Natural Sugars 2Genomatica Produces Pure BDO From Natural Sugars 3Genomatica Produces Pure BDO From Natural Sugars 4Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009 2Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009 3Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009 4Lexicon Names Ajay Bansal Executive Vice President and Chief Financial Officer 2Lexicon Names Ajay Bansal Executive Vice President and Chief Financial Officer 3
(Date:4/17/2014)... the Cell Press journal Current Biology on ... novel sex lives. The Brazilian insects, which represent four ... , are the first example of an animal with ... identified in several different animals, Neotrogla is ... also reversed," says Kazunori Yoshizawa from Hokkaido University in ...
(Date:4/17/2014)... are chock full of wild animals and plant life, ... fungi are churning away in the soil, decomposing organic ... the vital role these fungi play in ecological systems, ... team of scientists has generated a genetic map of ... The work was published this week in the ...
(Date:4/17/2014)... about domestication derive from Charles Darwin, whose ideas ... practices during the 19th century, a period when ... It is from Darwin that we inherit the ... from wild species and total human control over ... in this industrial setting has been applied too ...
Breaking Biology News(10 mins):In sex-reversed cave insects, females have the penises 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4
... dependent on the sun. Sunlight does not only supply ... So-called photoreceptors activate the processes of germination, leaf development, ... component of a photoreceptor may be replaced by a ... effects on complete plants are now described in the ...
... a study about to be published in EPJ E, French ... the behaviour of a thin layer of cells in contact ... fluid or elastic films. Understanding the mechanism by which a ... the layer,s structural integrity, bears great significance because the human ...
... release is available in Spanish . , Due ... region, many experts have claimed that they are millennia old but ... explained to SINC by the ecologist Bernat Claramunt from the Centre ... from this centre has now analysed the ages of the famous ...
Cached Biology News:The millennium-old olive trees of the Iberian Peninsula are younger than expected 2
PPOX Immunogen: PPOX (AAH02357, 378 a.a. ~ 478 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to Raf1 ( Abpromise for all tested applications). entrezGeneID: 5894 SwissProtID: P04049...
KRIT1 Immunogen: KRIT1 (NP_004903, 637 a.a. ~ 737 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Sheep polyclonal to hCG beta core fragment ( Abpromise for all tested applications). Antigen: Full length native protein (purified) from human urine. Entrez GeneID: 1082 Swiss Protein ID...
Biology Products: