Navigation Links
Adult cells transformed into early-stage nerve cells, bypassing the pluripotent stem cell stage
Date:5/2/2013

MADISON, Wis. A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells without passing through the do-it-all stage called the induced pluripotent stem cell, or iPSC.

Bypassing the ultra-flexible iPSC stage was a key advantage, says senior author Su-Chun Zhang, a professor of neuroscience and neurology. "IPSC cells can generate any cell type, which could be a problem for cell-based therapy to repair damage due to disease or injury in the nervous system."

In particular, the absence of iPSC cells rules out the formation of tumors by pluripotent cells in the recipient, a major concern involving stem cell therapy.

A second advance comes from the virus that delivers genes to reprogram the adult skin cells into a different and more flexible form. Unlike other viruses used for this process, the Sendai virus does not become part of the cell's genes.

Jianfeng Lu, Zhang's postdoctoral research associate at the UWMadison Waisman Center, removed skin cells from monkeys and people, and exposed them to Sendai virus for 24 hours. Lu then warmed the culture dish to kill the virus without harming the transforming cells. Thirteen days later, Lu was able to harvest a stem cell called an induced neural progenitor. After the progenitor was implanted into newborn mice, neural cells seemed to grow normally, without forming obvious defects or tumors, Zhang says.

Other researchers have bypassed the pluripotent stem cell stage while turning skin cells into neurons and other specialized cells, Zhang acknowledges, but the new research, just published in Cell Reports, had a different goal. "Our idea was to turn skin cells to neural progenitors, cells that can produce cells relating to the neural tissue. These progenitors can be propagated in large numbers."

The research overcomes limitations of previous efforts, Zhang sa
'/>"/>

Contact: Su-Chun Zhang
szhang4@wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Adult Acne Treatment, Probiotic Action Introduces their Antibiotic-Free Acne Treatment
2. Stem Cell Institute Public Seminar on Adult Stem Cell Therapy in Miami, Florida May 11th, 2013
3. Probiotic Action Announces Their Skin Care Treatment for Men Suffering from Adult Acne
4. Probiotic Action Shares New Insight on Why Adult Acne May Affect Women More than Men
5. Preliminary Research, Led By Dr. Vincent Giampapa, Finds Aged Adult Stem Cells Can Be Functionally Reprogrammed To Act Like Younger Cells
6. Probiotic Action Announces New Use for Their Adult Acne Treatment and Explains its Beauty Benefits for Women
7. More Than 100 Groups Support ABC-AHP-NCNPR Botanical Adulterants Program
8. Island Abbey Foods™ Honibe® Honey Delights® Now Available as Nature’s Tastiest Suckers™ for Kids and Adults
9. Island Abbey Foods Ltd™ Now Offering New Honibe® Honey Lozenges™ Flavour Variations for Both Adults and Children
10. Adult Stem Cell Therapy Breakthrough Leads to Crowd Funding Campaign on Indiegogo.com for Centagen, Inc.
11. Thackray Crane Rental Prepares Visible Memorial For The Newtown, Connecticut Children and Adults Who Were Ambushed and Taken Away From Their Families
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... England , Nov. 21, 2014   TRU-D SmartUVC ... will feature their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, ... this week from Nov. 23 to 26 at Stand 23. ... is the United Kingdom,s largest infection-related ... infection prevention societies to one of the leading events of ...
(Date:11/21/2014)... Angeles, CA (PRWEB) November 20, 2014 ... “A Short Walk to the Other Side” published ... an “Award-Winning Finalist in the “Fiction: Short Story” category ... , Jeffrey Keen, President and CEO of USA Book ... from mainstream and independent publishers, including Simon & Schuster, ...
(Date:11/21/2014)... 2014 The November 2014 issue of ... open access journal featuring the following articles:, ... preserve photoresponsiveness in the retina , DNA ... hybridization using chromogenic substrates in zebrafish , ... protein electrophoresis , Nuclear LC3-positive puncta in ...
(Date:11/21/2014)... 2014 Deep Research Report on ... professional and in-depth research report on the Sodium ... like its definition, classification, application, and industry chain ... covers the international market analysis, including China’s domestic ... US, Europe, Asia, China, Japan etc. regions) industry ...
Breaking Biology Technology:TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3
... In a merging of complementary companies, Cytochroma, Inc ., ... has acquired Proventiv Therapeutics, LLC, of Madison, and the combined ... capital from Canadian and American investors. , ,Proventiv was founded ... International , which was acquired last year by Genzyme ...
... Foundry , a provider of media communications technology, will be ... and family get in touch with their loved ones serving ... Wisconsin Department of Veterans Affairs to offer Mediasite ... , ,The messages can be recorded with both audio and ...
... recent legislative setbacks, proponents of net neutrality said their ... of the United States Senate not to take up ... are included. , ,The pro-neutrality group It'sOurNet , ... to reject the telecommunications bill following a tie vote ...
Cached Biology Technology:Canadian firm buys Proventiv Therapeutics, makes ex-Bone Care exec CEO 2Canadian firm buys Proventiv Therapeutics, makes ex-Bone Care exec CEO 3Net neutrality will be back, supporters vow 2Net neutrality will be back, supporters vow 3Net neutrality will be back, supporters vow 4
(Date:11/10/2014)... U.S. store shelves in early 2010, and people have ... packets can be tossed into a washing machine without ... The convenience, though, has come with risks for young ... Children,s Hospital found that from 2012 through 2013, U.S. ... than 6 years of age swallowing, inhaling, or otherwise ...
(Date:11/7/2014)... , November 6, 2014 Leading ... for better mobile security revolutionizing online transactions.  Companies in focus ... Holdings Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... ), eBay Inc. (NASDAQ: EBAY ) and MasterCard ... NXTD and NXTDW), a biometric authentication company focused on ...
(Date:11/6/2014)... when that predator runs so fast that it essentially blinds ... the fastest creature on Earth. Some of these half-inch-long beetles ... miles per hour). The fastest human can do about five ... beetle, a person would have to hit 480 miles per ... peak speeds, everything becomes a blur. They can,t gather enough ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6The tiger beetle: Too fast to see 2
... of Iowa researchers have found the existence of a new, ... find the genetic cause, which investigators hope will increase understanding ... the Nov. 9 issue of the Archives of Ophthalmology ... area of high-resolution central vision that is needed to read ...
... , , , ... www.kornberg.com ) has converted part of an existing building (Keen ... innovative stem cell core facility for the University of California, ... , "A key project element was to ensure ...
... WASHINGTON, Dec. 10, 2009 Arup K. SenGupta, Ph.D., ... Lehigh University in Bethlehem, Pa., has been chosen to ... administered by the American Chemical Society, is given to ... improve public health through their work in the chemical ...
Cached Biology News:New inherited eye disease discovered 2Kornberg Associates | Architects Completes UC Riverside Stem Cell Core Facility Project 2
RABBIT ANTI HUMAN APP (KP1 DOMAIN) Immunogen: Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP....
Anti-Goat HRP-AEC Cell & Tissue Staining Kit...
... CultureWell cell culture systems provide ... cultured cells for staining and ... silicone gaskets preassembled with standard ... plates. The entire system is ...
... Zero Background/Kan Cloning Kit includes ... resistance for selection in E. ... positive selection to eliminate high ... of the reagents you need ...
Biology Products: