Navigation Links
Adult cells transformed into early-stage nerve cells, bypassing the pluripotent stem cell stage
Date:5/2/2013

MADISON, Wis. A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells without passing through the do-it-all stage called the induced pluripotent stem cell, or iPSC.

Bypassing the ultra-flexible iPSC stage was a key advantage, says senior author Su-Chun Zhang, a professor of neuroscience and neurology. "IPSC cells can generate any cell type, which could be a problem for cell-based therapy to repair damage due to disease or injury in the nervous system."

In particular, the absence of iPSC cells rules out the formation of tumors by pluripotent cells in the recipient, a major concern involving stem cell therapy.

A second advance comes from the virus that delivers genes to reprogram the adult skin cells into a different and more flexible form. Unlike other viruses used for this process, the Sendai virus does not become part of the cell's genes.

Jianfeng Lu, Zhang's postdoctoral research associate at the UWMadison Waisman Center, removed skin cells from monkeys and people, and exposed them to Sendai virus for 24 hours. Lu then warmed the culture dish to kill the virus without harming the transforming cells. Thirteen days later, Lu was able to harvest a stem cell called an induced neural progenitor. After the progenitor was implanted into newborn mice, neural cells seemed to grow normally, without forming obvious defects or tumors, Zhang says.

Other researchers have bypassed the pluripotent stem cell stage while turning skin cells into neurons and other specialized cells, Zhang acknowledges, but the new research, just published in Cell Reports, had a different goal. "Our idea was to turn skin cells to neural progenitors, cells that can produce cells relating to the neural tissue. These progenitors can be propagated in large numbers."

The research overcomes limitations of previous efforts, Zhang sa
'/>"/>

Contact: Su-Chun Zhang
szhang4@wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Adult Acne Treatment, Probiotic Action Introduces their Antibiotic-Free Acne Treatment
2. Stem Cell Institute Public Seminar on Adult Stem Cell Therapy in Miami, Florida May 11th, 2013
3. Probiotic Action Announces Their Skin Care Treatment for Men Suffering from Adult Acne
4. Probiotic Action Shares New Insight on Why Adult Acne May Affect Women More than Men
5. Preliminary Research, Led By Dr. Vincent Giampapa, Finds Aged Adult Stem Cells Can Be Functionally Reprogrammed To Act Like Younger Cells
6. Probiotic Action Announces New Use for Their Adult Acne Treatment and Explains its Beauty Benefits for Women
7. More Than 100 Groups Support ABC-AHP-NCNPR Botanical Adulterants Program
8. Island Abbey Foods™ Honibe® Honey Delights® Now Available as Nature’s Tastiest Suckers™ for Kids and Adults
9. Island Abbey Foods Ltd™ Now Offering New Honibe® Honey Lozenges™ Flavour Variations for Both Adults and Children
10. Adult Stem Cell Therapy Breakthrough Leads to Crowd Funding Campaign on Indiegogo.com for Centagen, Inc.
11. Thackray Crane Rental Prepares Visible Memorial For The Newtown, Connecticut Children and Adults Who Were Ambushed and Taken Away From Their Families
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2015)... San Francisco, CA (PRWEB) April 16, 2015 ... is scheduled to report first quarter results on Thursday, ... the announcement, Cytokinetics’ senior management will host a conference ... and financial results and the company’s outlook for the ... and can be accessed from the homepage and in ...
(Date:4/16/2015)... 16, 2015 Proove Biosciences , ... of BIO Contest for the 2015 BIO International ... 2015 BIO International Convention will take place June 15-18 ... the Buzz of BIO contest, industry leaders will be ... at the conference. The community voting period began on ...
(Date:4/16/2015)... Regis Technologies looks forward to being part ... (AACR) annual meeting. Regis will exhibit at this year's ... 18, in Philadelphia and running through April 22, 2015. ... oldest and largest organization focused on cancer research. It ... with survivors to promote awareness and research funding. ...
(Date:4/16/2015)... 2015 OncoTAb, Inc., ... Charlotte) spin-out company, announced today the appointment of ... as Chief Operating Officer (COO). Cooper brings to ... developing clinical diagnostic and biotechnology platforms in the ... Cooper’s extensive career transcends the field of medical ...
Breaking Biology Technology:Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2OncoTAb Names Dr. David L. Cooper as COO 2
... Technologies, Inc. has received a written notification from the ... to file financial reports for the quarter ending March 31, ... common stock from NASDAQ. , ,Representatives of Merge, which ... Listing Qualifications Panel to request that the panel grant Merge ...
... Milwaukee, Wis . - David Melbye hasn't been ... already has a significant information technology project under his ... Sewerage District , is wrapping up a major IT ... by the district's governing commission. While he's pleased with ...
... - Wisconsin Gov. Jim Doyle , noting that ... bipartisan legislation to overturn President Bush's ban on ... is delaying critical scientific research. , ,Doyle noted that ... to follow through on a commitment to schedule a vote ...
Cached Biology Technology:CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 2CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 3CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 4CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 5
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/18/2015)... -- As mobile payments become more prevalent amongst ... apps continue to be introduced into the market place at ... industry in focus today are:  NXT-ID, Inc. (NASDAQ: ... ), Apple Inc. (NASDAQ: AAPL ), Google Inc. ... FB ) NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... , Jos Carlos Mendes Santos (a.k.a. Louro) is a handyman ... of the world with the highest biodiversity. Two years ago, ... the backyards of the off-the-grid house of amateur botanist and ... home to be grown on a window sill for closer ...
... N.C. -- The number of sea turtles accidentally caught and ... declined by an estimated 90 percent since 1990, according to ... and Conservation International. The report, published in the scientific ... measures that have been put into place over the last ...
... Important changes that will affect the publication of new ... International Botanical Congress are detailed in a paper that is ... total of sixteen leading academic journals. The paper, co-authored by ... Louis), presents the draft text of new articles to the ...
Cached Biology News:Amateur botanists in Brazil discover a genuflexing plant 2Amateur botanists in Brazil discover a genuflexing plant 3Accidental sea turtle deaths drop 90 percent in US fisheries 2Accidental sea turtle deaths drop 90 percent in US fisheries 3Revolutionary changes to the Botanical Code published in 16 journals and 5 languages 2
Request Info...
Prepared in distilled water....
... egg white. The extinction coefficient , E(1%) ... mM phosphate-buffered saline, pH 7.4, ... and 50% glycerol. Avidin (from egg white) is ... by molecular sieving and is ...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
Biology Products: