Navigation Links
AcelRx Pharmaceuticals Reports Positive Results From a Phase 2 Clinical Trial of Sublingual Sufentanil NanoTabs(TM) in Treating Post-Operative Pain
Date:12/9/2008

REDWOOD CITY, Calif., Dec. 9 /PRNewswire/ -- AcelRx Pharmaceuticals, Inc. today announced positive results from a Phase 2 clinical study evaluating the safety and efficacy of its lead product candidate, ARX-01, for the treatment of moderate-to-severe inpatient acute pain following knee replacement surgery. The primary endpoint evaluated pain intensity (Sum of the Pain Intensity Difference - SPID12) over the 12-hour study period compared to baseline. Results demonstrated that compared to placebo, patients receiving 15 mcg of ARX-01 experienced a statistically significant reduction in pain intensity over the study period, based on the worst observation carried forward imputation method (WOCF), p=0.015. Additionally, at the 15 mcg dose, the study met an important secondary endpoint compared to placebo, the percentage of patient dropouts due to inadequate analgesia, p=0.006. Further, no serious or unexpected adverse events related to ARX-01 were reported in the study.

ARX-01 is a sublingual formulation of the opioid pain medication, sufentanil. ARX-01 is based on the company's proprietary NanoTab(TM) dosage form, which enables delivery of sufentanil by the non-invasive oral transmucosal (sublingual) route.

"We chose a very painful surgery in an elderly patient population to showcase the efficacy and safety of Sublingual Sufentanil NanoTabs in treating acute post-operative pain," said Pamela Palmer, M.D., Ph.D., chief medical officer of AcelRx Pharmaceuticals. "The superior attributes of both the drug and the dosage form enabled these highly encouraging Phase 2 results."

This multicenter, double-blind, randomized, placebo-controlled, dose-finding Phase 2 study evaluated the safety and efficacy of ARX-01 in patients undergoing elective unilateral knee replacement surgery. In the study, 101 patients were randomized to receive either placebo or one of three different dosage strengths of ARX-01: 5mcg, 10m
'/>"/>

SOURCE AcelRx Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes
2. China Biopharmaceuticals Holdings Announces Second Quarter 2007 Financial Results
3. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
4. XTL Biopharmaceuticals Announces Financial Results for the Six Months Ended June 30, 2007
5. Cadence Pharmaceuticals Reports Second Quarter 2007 Financial Results
6. Nabi Biopharmaceuticals to Present at Upcoming Industry Conferences
7. Anadys Pharmaceuticals Appoints Steve Worland, Ph.D. as President and Chief Executive Officer
8. Poniard Pharmaceuticals Announces Participation in Upcoming Conferences
9. NovaQuest Advances Virtual Development Model With Strategic Investment in TOPIGEN Pharmaceuticals
10. Drug Royalty Corporation (DRC) Announces Acquisition Regarding PEG-INTRON(R) From Enzon Pharmaceuticals, Inc. (ENZN)
11. Sunesis Pharmaceuticals Announces Reorganization to Focus Resources and Build Value in Clinical-Stage Programs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
(Date:1/14/2014)... Diego, CA (PRWEB) January 14, 2014 ... on the products of cells grown under simulated embryonic ... international license agreement with Suneva Medical, Inc. for physician-dispensed ... (CCM). , This agreement is an amendment ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 EquitiesIQ, a ... Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical company ... the wound care market. , Free report download: ... with a seasoned management team and Board, which launched ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, ... Strategy. In this role, Michelle will work with current and ... the development of iLab products. Her main goal will be ... the scientific community by offering the most advanced, user-friendly, and ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... Data to be Presented at the 7th International ... Symposium on Uveitis ... a leading,developer of antibody fragment therapeutics, today announced that the,company ... lead product candidate, ESBA105, in ophthalmic indications. In,April 2008, ESBATech ...
... DNA TESTING FOR $59.95, THE MOST AFFORDABLE PRICING AVAILABLE ... ... Sept. 8 Familybuilder today announces from,the DEMOfall 08 conference here ... http://www.familybuilder.com ) and the introduction of $59.95 DNA tests,the most ...
... NOCC Spokesperson, Eva La Rue, Lends Her Support as, ... Ovarian Cancer -, LOS ANGELES, Sept. 6 ... national haircare and styling partner,is hosting the first annual ... Cancer" at Dockweiler Beach in Playa del Ray, CA. ...
Cached Biology Technology:ESBATech Announces Successful Completion of Phase I Clinical Study for Lead Antibody Fragment in Ophthalmic Indications 2Familybuilder Launches the Familybuilder Global Network at DEMOfall 08 2Familybuilder Launches the Familybuilder Global Network at DEMOfall 08 3National Ovarian Cancer Coalition and PureOlogy to Host First Annual 'NOCC and PureOlogy's Walk to Break the Silence on Ovarian Cancer' 2National Ovarian Cancer Coalition and PureOlogy to Host First Annual 'NOCC and PureOlogy's Walk to Break the Silence on Ovarian Cancer' 3
(Date:4/24/2014)... Ind. - Purdue and West Virginia University researchers are ... eagle, providing a bird,s-eye view of eagle features that ... Their study calls into question long-held assumptions about golden ... as sensitive to ultraviolet light as previously thought. The ... sharper sense of smell than researchers realized. , ...
(Date:4/24/2014)... Rochelle, NY, April 24, 2014D-ribose is a commercially ... supplement, and as a starting compound for synthesizing ... Escherichia coli to increase the bacteria,s ... toward achieving more efficient industrial-scale production of this ... Industrial Biotechnology , a peer-reviewed journal from ...
(Date:4/24/2014)... have invented a simple and cheap way of making ... into a high-resolution microscope. , Costing less than a ... medicine in developing countries and remote areas. , The ... from The Australian National University (ANU) Research School of ... Garvan Institute of Medical Research to find ways to ...
Breaking Biology News(10 mins):Genome yields insights into golden eagle vision, smell 2Droplet lens 2
... enables rice to survive complete submergence has beenidentified ... RiceResearch Institute in the Philippines and at the ... allows fordevelopment of new rice varieties that can ... and offering reliefto millions of poor rice farmers ...
... alien species have invaded, they usually find predictable patterns. ... in natural processes such as nutrient cycling, wildfire frequency ... , But simply observing such changes doesn't prove that ... researchers Emily Farrer and Deborah Goldberg, however, came up ...
... time in as many months, the IODP Arctic Coring Expedition ... In the Aug. 10 issue of Nature, an article by ... that the Arctic was extremely warm, unusually wet, and ice-free ... gases were released into the Earth's atmosphere ?a period calculated ...
Cached Biology News:New flood-tolerant rice offers relief for world's poorest farmers 2New flood-tolerant rice offers relief for world's poorest farmers 3Invasive species alter habitat to their benefit 2Invasive species alter habitat to their benefit 3Arctic coring expedition continues to yield new clues 2
Ezrin/Radixin/Moesin Antibody...
Anti-Mouse C-10, Biotin (Polyclonal) (rabbit IgG)...
... Rabbit polyclonal to ADAMTS16 ( Abpromise ... Antigen: Synthetic peptide ... human ADAMTS-16. Note: the amino acid ... Entrez GeneID: 170690 ...
Purified Mouse anti-Hu Actopaxin (pS8) Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: