Professor Jean-Charles Fruchart, President of the Residual Risk Reduction Initiative (R3i), an independent Swiss academic foundation, said: 'For the last two years, the R3i has focused on the hypothesis that residual cardiovascular risk in statin-treated patients is associated with atherogenic dyslipidemia.(2,3) ACCORD Lipid confirms both the hypothesis and the value of adding fenofibrate to a statin to reduce this high residual cardiovascular risk. This is consistent with current guidelines from the American Diabetes Association(4) and the National Cholesterol Education Program Adult Treatment Panel III.(5)'
The benefit of fenofibrate was only seen in the pre-specified group of diabetic patients with atherogenic dyslipidemia and not in the total study population. 'While patients with atherogenic dyslipidemia only represented 17 percent of the ACCORD Lipid population, in clinical practice the size of the problem is significantly greater. We are now quantifying this in the R3i-funded REsiduAl risk Lipids and Standard Therapies (REALIST) study which is being conducted at Harvard Medical School and over 20 well-known academic centers worldwide,' said Professor Frank Sacks of Harvard Medical School, Boston, USA and Vice-President of the R3i.
In ACCORD Lipid, fenofibrate also reduced micro- and macro-albuminuria,
markers of diabetic
|SOURCE Residual Risk Reduction initiative (R3i)|
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